| Full name: arachidonate lipoxygenase 3 | Alias Symbol: eLOX3|E-LOX | ||
| Type: protein-coding gene | Cytoband: 17p13.1 | ||
| Entrez ID: 59344 | HGNC ID: HGNC:13743 | Ensembl Gene: ENSG00000179148 | OMIM ID: 607206 |
| Drug and gene relationship at DGIdb | |||
Expression of ALOXE3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ALOXE3 | 59344 | 207708_at | 0.4896 | 0.5223 | |
| GSE20347 | ALOXE3 | 59344 | 207708_at | 0.1365 | 0.2396 | |
| GSE23400 | ALOXE3 | 59344 | 207708_at | -0.1025 | 0.1006 | |
| GSE26886 | ALOXE3 | 59344 | 207708_at | 0.0627 | 0.6544 | |
| GSE29001 | ALOXE3 | 59344 | 207708_at | 0.0785 | 0.7685 | |
| GSE38129 | ALOXE3 | 59344 | 207708_at | 0.0246 | 0.8490 | |
| GSE45670 | ALOXE3 | 59344 | 207708_at | 0.5574 | 0.0047 | |
| GSE53622 | ALOXE3 | 59344 | 154862 | 1.0655 | 0.0032 | |
| GSE53624 | ALOXE3 | 59344 | 154862 | 0.6936 | 0.0005 | |
| GSE63941 | ALOXE3 | 59344 | 207708_at | 0.2900 | 0.1279 | |
| GSE77861 | ALOXE3 | 59344 | 207708_at | 0.3505 | 0.0496 | |
| GSE97050 | ALOXE3 | 59344 | A_24_P347880 | 0.8158 | 0.2336 | |
| SRP133303 | ALOXE3 | 59344 | RNAseq | 1.3827 | 0.0292 | |
| SRP159526 | ALOXE3 | 59344 | RNAseq | 1.7989 | 0.0174 | |
| SRP219564 | ALOXE3 | 59344 | RNAseq | 1.7560 | 0.1101 | |
| TCGA | ALOXE3 | 59344 | RNAseq | 1.3827 | 0.0001 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by ALOXE3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ALOXE3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ALOXE3 | 59344 | 4 | 2 | 24 | |
| GSE20123 | ALOXE3 | 59344 | 4 | 3 | 23 | |
| GSE43470 | ALOXE3 | 59344 | 1 | 6 | 36 | |
| GSE46452 | ALOXE3 | 59344 | 34 | 1 | 24 | |
| GSE47630 | ALOXE3 | 59344 | 7 | 1 | 32 | |
| GSE54993 | ALOXE3 | 59344 | 4 | 3 | 63 | |
| GSE54994 | ALOXE3 | 59344 | 5 | 8 | 40 | |
| GSE60625 | ALOXE3 | 59344 | 4 | 0 | 7 | |
| GSE74703 | ALOXE3 | 59344 | 1 | 3 | 32 | |
| GSE74704 | ALOXE3 | 59344 | 2 | 1 | 17 | |
| TCGA | ALOXE3 | 59344 | 17 | 21 | 58 |
Total number of gains: 83; Total number of losses: 49; Total Number of normals: 356.
Somatic mutations of ALOXE3:
Generating mutation plots.
Highly correlated genes for ALOXE3:
Showing top 20/441 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ALOXE3 | SPRR2G | 0.755645 | 8 | 0 | 7 |
| ALOXE3 | MYH9 | 0.749143 | 3 | 0 | 3 |
| ALOXE3 | PLA2G4E | 0.72543 | 3 | 0 | 3 |
| ALOXE3 | TNFRSF1A | 0.69253 | 4 | 0 | 4 |
| ALOXE3 | GLI2 | 0.692018 | 3 | 0 | 3 |
| ALOXE3 | LMF2 | 0.688728 | 3 | 0 | 3 |
| ALOXE3 | KHSRP | 0.688529 | 3 | 0 | 3 |
| ALOXE3 | KRTDAP | 0.686594 | 7 | 0 | 6 |
| ALOXE3 | TTYH3 | 0.683407 | 3 | 0 | 3 |
| ALOXE3 | IMPDH1 | 0.68232 | 3 | 0 | 3 |
| ALOXE3 | IL36G | 0.68205 | 7 | 0 | 6 |
| ALOXE3 | WFDC5 | 0.67619 | 7 | 0 | 6 |
| ALOXE3 | RPL39L | 0.676092 | 3 | 0 | 3 |
| ALOXE3 | CEACAM19 | 0.663638 | 7 | 0 | 6 |
| ALOXE3 | LCE3E | 0.659563 | 4 | 0 | 3 |
| ALOXE3 | GSDMA | 0.657624 | 4 | 0 | 3 |
| ALOXE3 | MBL2 | 0.657515 | 4 | 0 | 3 |
| ALOXE3 | PRR9 | 0.65457 | 5 | 0 | 5 |
| ALOXE3 | SLC4A2 | 0.654191 | 3 | 0 | 3 |
| ALOXE3 | LCE3D | 0.649261 | 8 | 0 | 5 |
For details and further investigation, click here
