| Full name: arachidonate 12-lipoxygenase, 12R type | Alias Symbol: 12R-LOX | ||
| Type: protein-coding gene | Cytoband: 17p13.1 | ||
| Entrez ID: 242 | HGNC ID: HGNC:430 | Ensembl Gene: ENSG00000179477 | OMIM ID: 603741 |
| Drug and gene relationship at DGIdb | |||
Expression of ALOX12B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ALOX12B | 242 | 207381_at | 0.1347 | 0.9571 | |
| GSE20347 | ALOX12B | 242 | 207381_at | -0.1718 | 0.7470 | |
| GSE23400 | ALOX12B | 242 | 207381_at | -0.3601 | 0.0701 | |
| GSE26886 | ALOX12B | 242 | 207381_at | -0.3094 | 0.5501 | |
| GSE29001 | ALOX12B | 242 | 207381_at | -0.1564 | 0.8736 | |
| GSE38129 | ALOX12B | 242 | 207381_at | 0.3093 | 0.4913 | |
| GSE45670 | ALOX12B | 242 | 207381_at | 2.5446 | 0.0002 | |
| GSE53622 | ALOX12B | 242 | 79187 | 0.3424 | 0.1812 | |
| GSE53624 | ALOX12B | 242 | 79187 | -0.2038 | 0.3248 | |
| GSE63941 | ALOX12B | 242 | 207381_at | 0.5544 | 0.1682 | |
| GSE77861 | ALOX12B | 242 | 207381_at | 0.9950 | 0.0502 | |
| GSE97050 | ALOX12B | 242 | A_23_P83634 | 0.3000 | 0.4823 | |
| SRP007169 | ALOX12B | 242 | RNAseq | -1.2929 | 0.1685 | |
| SRP133303 | ALOX12B | 242 | RNAseq | -0.3759 | 0.6622 | |
| SRP159526 | ALOX12B | 242 | RNAseq | 1.7148 | 0.0479 | |
| TCGA | ALOX12B | 242 | RNAseq | 0.8181 | 0.0430 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by ALOX12B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ALOX12B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ALOX12B | 242 | 4 | 2 | 24 | |
| GSE20123 | ALOX12B | 242 | 4 | 3 | 23 | |
| GSE43470 | ALOX12B | 242 | 1 | 6 | 36 | |
| GSE46452 | ALOX12B | 242 | 34 | 1 | 24 | |
| GSE47630 | ALOX12B | 242 | 7 | 1 | 32 | |
| GSE54993 | ALOX12B | 242 | 4 | 3 | 63 | |
| GSE54994 | ALOX12B | 242 | 5 | 8 | 40 | |
| GSE60625 | ALOX12B | 242 | 4 | 0 | 7 | |
| GSE74703 | ALOX12B | 242 | 1 | 3 | 32 | |
| GSE74704 | ALOX12B | 242 | 2 | 1 | 17 | |
| TCGA | ALOX12B | 242 | 17 | 21 | 58 |
Total number of gains: 83; Total number of losses: 49; Total Number of normals: 356.
Somatic mutations of ALOX12B:
Generating mutation plots.
Highly correlated genes for ALOX12B:
Showing top 20/137 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ALOX12B | YEATS2 | 0.776082 | 3 | 0 | 3 |
| ALOX12B | TMCC2 | 0.746002 | 3 | 0 | 3 |
| ALOX12B | LCE3E | 0.729851 | 4 | 0 | 4 |
| ALOX12B | ETAA1 | 0.726958 | 3 | 0 | 3 |
| ALOX12B | FOXL2 | 0.721136 | 3 | 0 | 3 |
| ALOX12B | TRIM11 | 0.718576 | 3 | 0 | 3 |
| ALOX12B | CDCA5 | 0.709003 | 3 | 0 | 3 |
| ALOX12B | PLA2G4E | 0.702671 | 3 | 0 | 3 |
| ALOX12B | HOXC9 | 0.700447 | 3 | 0 | 3 |
| ALOX12B | BEND3 | 0.699249 | 4 | 0 | 4 |
| ALOX12B | LINC00302 | 0.698471 | 3 | 0 | 3 |
| ALOX12B | RAD51 | 0.686912 | 3 | 0 | 3 |
| ALOX12B | NUP62CL | 0.685743 | 3 | 0 | 3 |
| ALOX12B | SPRR2G | 0.684592 | 8 | 0 | 8 |
| ALOX12B | DUSP9 | 0.681628 | 3 | 0 | 3 |
| ALOX12B | BLACAT1 | 0.666894 | 3 | 0 | 3 |
| ALOX12B | FPR1 | 0.666742 | 3 | 0 | 3 |
| ALOX12B | EPB41L4B | 0.666532 | 4 | 0 | 4 |
| ALOX12B | KRTDAP | 0.665973 | 7 | 0 | 6 |
| ALOX12B | NPW | 0.665183 | 3 | 0 | 3 |
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