| Full name: patatin like phospholipase domain containing 7 | Alias Symbol: FLJ43070|FLJ31318|FLJ44279|RP11-48C7.2|NTEL1|NTE-R1 | ||
| Type: protein-coding gene | Cytoband: 9q34.3 | ||
| Entrez ID: 375775 | HGNC ID: HGNC:24768 | Ensembl Gene: ENSG00000130653 | OMIM ID: 612122 |
| Drug and gene relationship at DGIdb | |||
Expression of PNPLA7:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PNPLA7 | 375775 | 228383_at | -0.4220 | 0.2152 | |
| GSE26886 | PNPLA7 | 375775 | 228383_at | 0.1381 | 0.2645 | |
| GSE45670 | PNPLA7 | 375775 | 228383_at | -0.1459 | 0.1350 | |
| GSE53622 | PNPLA7 | 375775 | 90407 | 0.2320 | 0.0054 | |
| GSE53624 | PNPLA7 | 375775 | 90407 | 0.0088 | 0.9503 | |
| GSE63941 | PNPLA7 | 375775 | 228383_at | -0.0832 | 0.5867 | |
| GSE77861 | PNPLA7 | 375775 | 228383_at | -0.2515 | 0.0665 | |
| GSE97050 | PNPLA7 | 375775 | A_33_P3666884 | -0.0634 | 0.8443 | |
| SRP064894 | PNPLA7 | 375775 | RNAseq | -1.0312 | 0.0007 | |
| SRP133303 | PNPLA7 | 375775 | RNAseq | -1.6628 | 0.0000 | |
| SRP159526 | PNPLA7 | 375775 | RNAseq | -0.7921 | 0.0233 | |
| SRP193095 | PNPLA7 | 375775 | RNAseq | -1.2775 | 0.0000 | |
| SRP219564 | PNPLA7 | 375775 | RNAseq | -1.1918 | 0.0277 | |
| TCGA | PNPLA7 | 375775 | RNAseq | -1.6619 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by PNPLA7 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PNPLA7:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PNPLA7 | 375775 | 5 | 7 | 18 | |
| GSE20123 | PNPLA7 | 375775 | 5 | 7 | 18 | |
| GSE43470 | PNPLA7 | 375775 | 3 | 7 | 33 | |
| GSE46452 | PNPLA7 | 375775 | 6 | 13 | 40 | |
| GSE47630 | PNPLA7 | 375775 | 6 | 15 | 19 | |
| GSE54993 | PNPLA7 | 375775 | 3 | 3 | 64 | |
| GSE54994 | PNPLA7 | 375775 | 19 | 3 | 31 | |
| GSE60625 | PNPLA7 | 375775 | 0 | 0 | 11 | |
| GSE74703 | PNPLA7 | 375775 | 3 | 5 | 28 | |
| GSE74704 | PNPLA7 | 375775 | 3 | 5 | 12 | |
| TCGA | PNPLA7 | 375775 | 30 | 23 | 43 |
Total number of gains: 83; Total number of losses: 88; Total Number of normals: 317.
Somatic mutations of PNPLA7:
Generating mutation plots.
Highly correlated genes for PNPLA7:
Showing top 20/482 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PNPLA7 | SUN5 | 0.880127 | 3 | 0 | 3 |
| PNPLA7 | ZNF843 | 0.876591 | 3 | 0 | 3 |
| PNPLA7 | OR2T27 | 0.861611 | 3 | 0 | 3 |
| PNPLA7 | DCDC1 | 0.853071 | 3 | 0 | 3 |
| PNPLA7 | TMEM229A | 0.807804 | 3 | 0 | 3 |
| PNPLA7 | YY2 | 0.802992 | 3 | 0 | 3 |
| PNPLA7 | KRTAP10-12 | 0.802579 | 3 | 0 | 3 |
| PNPLA7 | OR2A5 | 0.798768 | 3 | 0 | 3 |
| PNPLA7 | BBC3 | 0.797115 | 3 | 0 | 3 |
| PNPLA7 | OR2T1 | 0.795259 | 3 | 0 | 3 |
| PNPLA7 | MYOZ3 | 0.793483 | 3 | 0 | 3 |
| PNPLA7 | CATSPER3 | 0.791516 | 3 | 0 | 3 |
| PNPLA7 | IGSF9B | 0.790645 | 3 | 0 | 3 |
| PNPLA7 | AQP4 | 0.78191 | 3 | 0 | 3 |
| PNPLA7 | FGF22 | 0.780975 | 3 | 0 | 3 |
| PNPLA7 | BSND | 0.780957 | 3 | 0 | 3 |
| PNPLA7 | CIB3 | 0.780427 | 4 | 0 | 4 |
| PNPLA7 | TSPAN11 | 0.777772 | 3 | 0 | 3 |
| PNPLA7 | NKX6-3 | 0.775266 | 4 | 0 | 4 |
| PNPLA7 | PABPN1L | 0.775017 | 3 | 0 | 3 |
For details and further investigation, click here
