| Full name: aquaporin 4 | Alias Symbol: MIWC | ||
| Type: protein-coding gene | Cytoband: 18q11.2 | ||
| Entrez ID: 361 | HGNC ID: HGNC:637 | Ensembl Gene: ENSG00000171885 | OMIM ID: 600308 |
| Drug and gene relationship at DGIdb | |||
Expression of AQP4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AQP4 | 361 | 210068_s_at | -0.0789 | 0.7140 | |
| GSE20347 | AQP4 | 361 | 210068_s_at | -0.0089 | 0.8929 | |
| GSE23400 | AQP4 | 361 | 210068_s_at | -0.0380 | 0.1998 | |
| GSE26886 | AQP4 | 361 | 210068_s_at | 0.1778 | 0.2328 | |
| GSE29001 | AQP4 | 361 | 210068_s_at | -0.1654 | 0.0941 | |
| GSE38129 | AQP4 | 361 | 210068_s_at | -0.0953 | 0.1326 | |
| GSE45670 | AQP4 | 361 | 210068_s_at | 0.1026 | 0.2468 | |
| GSE53622 | AQP4 | 361 | 16052 | 0.1722 | 0.1014 | |
| GSE53624 | AQP4 | 361 | 16052 | 0.3100 | 0.0003 | |
| GSE63941 | AQP4 | 361 | 210068_s_at | 0.3090 | 0.7429 | |
| GSE77861 | AQP4 | 361 | 210068_s_at | -0.0507 | 0.5367 | |
| GSE97050 | AQP4 | 361 | A_33_P3420757 | -0.2054 | 0.4585 | |
| TCGA | AQP4 | 361 | RNAseq | -4.1413 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by AQP4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AQP4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AQP4 | 361 | 2 | 5 | 23 | |
| GSE20123 | AQP4 | 361 | 2 | 5 | 23 | |
| GSE43470 | AQP4 | 361 | 0 | 2 | 41 | |
| GSE46452 | AQP4 | 361 | 1 | 25 | 33 | |
| GSE47630 | AQP4 | 361 | 5 | 19 | 16 | |
| GSE54993 | AQP4 | 361 | 7 | 1 | 62 | |
| GSE54994 | AQP4 | 361 | 3 | 14 | 36 | |
| GSE60625 | AQP4 | 361 | 0 | 4 | 7 | |
| GSE74703 | AQP4 | 361 | 0 | 2 | 34 | |
| GSE74704 | AQP4 | 361 | 1 | 4 | 15 | |
| TCGA | AQP4 | 361 | 15 | 34 | 47 |
Total number of gains: 36; Total number of losses: 115; Total Number of normals: 337.
Somatic mutations of AQP4:
Generating mutation plots.
Highly correlated genes for AQP4:
Showing top 20/571 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AQP4 | CLCNKA | 0.812535 | 3 | 0 | 3 |
| AQP4 | TMEM229A | 0.800268 | 3 | 0 | 3 |
| AQP4 | OR2T1 | 0.788656 | 3 | 0 | 3 |
| AQP4 | DCDC1 | 0.786633 | 3 | 0 | 3 |
| AQP4 | CIB3 | 0.785976 | 3 | 0 | 3 |
| AQP4 | PNPLA7 | 0.78191 | 3 | 0 | 3 |
| AQP4 | OR2H2 | 0.781879 | 3 | 0 | 3 |
| AQP4 | BBC3 | 0.781638 | 3 | 0 | 3 |
| AQP4 | MRGPRG | 0.779243 | 3 | 0 | 3 |
| AQP4 | OR2T27 | 0.778448 | 3 | 0 | 3 |
| AQP4 | PRSS38 | 0.776518 | 3 | 0 | 3 |
| AQP4 | KCNH3 | 0.776397 | 3 | 0 | 3 |
| AQP4 | C1QL2 | 0.773561 | 3 | 0 | 3 |
| AQP4 | PABPN1L | 0.771666 | 3 | 0 | 3 |
| AQP4 | YY2 | 0.770284 | 3 | 0 | 3 |
| AQP4 | ANO7 | 0.768784 | 4 | 0 | 4 |
| AQP4 | BSX | 0.76699 | 3 | 0 | 3 |
| AQP4 | OR2B11 | 0.760044 | 3 | 0 | 3 |
| AQP4 | TTLL9 | 0.759971 | 3 | 0 | 3 |
| AQP4 | INSC | 0.75778 | 4 | 0 | 3 |
For details and further investigation, click here
