| Full name: serum/glucocorticoid regulated kinase family member 3 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 8q13.1 | ||
| Entrez ID: 23678 | HGNC ID: HGNC:10812 | Ensembl Gene: ENSG00000104205 | OMIM ID: 607591 |
| Drug and gene relationship at DGIdb | |||
SGK3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04068 | FoxO signaling pathway | |
| hsa04068 | FoxO signaling pathway | |
| hsa04151 | PI3K-Akt signaling pathway | |
| hsa04151 | PI3K-Akt signaling pathway |
Expression of SGK3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE53622 | SGK3 | 23678 | 96048 | -0.1469 | 0.1809 | |
| GSE53624 | SGK3 | 23678 | 96048 | -0.1409 | 0.1817 | |
| GSE97050 | SGK3 | 23678 | A_24_P46953 | -0.0226 | 0.9314 | |
| SRP007169 | SGK3 | 23678 | RNAseq | 0.2763 | 0.5018 | |
| SRP008496 | SGK3 | 23678 | RNAseq | 0.3018 | 0.5172 | |
| SRP064894 | SGK3 | 23678 | RNAseq | 0.1621 | 0.6972 | |
| SRP133303 | SGK3 | 23678 | RNAseq | 0.2352 | 0.2830 | |
| SRP159526 | SGK3 | 23678 | RNAseq | -0.0921 | 0.8079 | |
| SRP193095 | SGK3 | 23678 | RNAseq | -0.1500 | 0.3246 | |
| SRP219564 | SGK3 | 23678 | RNAseq | 0.5522 | 0.1442 | |
| TCGA | SGK3 | 23678 | RNAseq | -0.0415 | 0.6157 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SGK3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SGK3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SGK3 | 23678 | 15 | 1 | 14 | |
| GSE20123 | SGK3 | 23678 | 16 | 1 | 13 | |
| GSE43470 | SGK3 | 23678 | 15 | 3 | 25 | |
| GSE46452 | SGK3 | 23678 | 20 | 2 | 37 | |
| GSE47630 | SGK3 | 23678 | 23 | 1 | 16 | |
| GSE54993 | SGK3 | 23678 | 1 | 18 | 51 | |
| GSE54994 | SGK3 | 23678 | 30 | 0 | 23 | |
| GSE60625 | SGK3 | 23678 | 0 | 4 | 7 | |
| GSE74703 | SGK3 | 23678 | 13 | 2 | 21 | |
| GSE74704 | SGK3 | 23678 | 11 | 0 | 9 | |
| TCGA | SGK3 | 23678 | 49 | 4 | 43 |
Total number of gains: 193; Total number of losses: 36; Total Number of normals: 259.
Somatic mutations of SGK3:
Generating mutation plots.
Highly correlated genes for SGK3:
Showing all 12 correlated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SGK3 | DECR1 | 0.714094 | 3 | 0 | 3 |
| SGK3 | TIGD6 | 0.700124 | 3 | 0 | 3 |
| SGK3 | ZNF700 | 0.691699 | 3 | 0 | 3 |
| SGK3 | RNF125 | 0.685388 | 3 | 0 | 3 |
| SGK3 | DCP2 | 0.676041 | 3 | 0 | 3 |
| SGK3 | SS18 | 0.667024 | 3 | 0 | 3 |
| SGK3 | GRAMD4 | 0.661582 | 3 | 0 | 3 |
| SGK3 | MBLAC2 | 0.660982 | 3 | 0 | 3 |
| SGK3 | ARMCX5 | 0.649647 | 3 | 0 | 3 |
| SGK3 | TNFAIP8L2 | 0.644872 | 3 | 0 | 3 |
| SGK3 | VCPIP1 | 0.591935 | 4 | 0 | 3 |
| SGK3 | HELQ | 0.580918 | 3 | 0 | 3 |
For details and further investigation, click here
