| Full name: 2,4-dienoyl-CoA reductase 1 | Alias Symbol: SDR18C1 | ||
| Type: protein-coding gene | Cytoband: 8q21.3 | ||
| Entrez ID: 1666 | HGNC ID: HGNC:2753 | Ensembl Gene: ENSG00000104325 | OMIM ID: 222745 |
| Drug and gene relationship at DGIdb | |||
Expression of DECR1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DECR1 | 1666 | 202447_at | -0.0287 | 0.9668 | |
| GSE20347 | DECR1 | 1666 | 202447_at | -0.6151 | 0.0014 | |
| GSE23400 | DECR1 | 1666 | 202447_at | -0.2786 | 0.0008 | |
| GSE26886 | DECR1 | 1666 | 202447_at | -0.2239 | 0.1562 | |
| GSE29001 | DECR1 | 1666 | 202447_at | -0.4917 | 0.0710 | |
| GSE38129 | DECR1 | 1666 | 202447_at | -0.4152 | 0.0022 | |
| GSE45670 | DECR1 | 1666 | 202447_at | -0.0851 | 0.5328 | |
| GSE53622 | DECR1 | 1666 | 94837 | -0.5413 | 0.0000 | |
| GSE53624 | DECR1 | 1666 | 94837 | -0.6203 | 0.0000 | |
| GSE63941 | DECR1 | 1666 | 202447_at | -1.6457 | 0.3031 | |
| GSE77861 | DECR1 | 1666 | 202447_at | -0.6416 | 0.0816 | |
| GSE97050 | DECR1 | 1666 | A_24_P269619 | 0.1092 | 0.5844 | |
| SRP007169 | DECR1 | 1666 | RNAseq | -1.2152 | 0.0027 | |
| SRP008496 | DECR1 | 1666 | RNAseq | -1.0282 | 0.0000 | |
| SRP064894 | DECR1 | 1666 | RNAseq | -0.0994 | 0.5510 | |
| SRP133303 | DECR1 | 1666 | RNAseq | -0.2761 | 0.1301 | |
| SRP159526 | DECR1 | 1666 | RNAseq | -0.4632 | 0.1237 | |
| SRP193095 | DECR1 | 1666 | RNAseq | -0.8063 | 0.0000 | |
| TCGA | DECR1 | 1666 | RNAseq | -0.1184 | 0.0288 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by DECR1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DECR1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DECR1 | 1666 | 14 | 1 | 15 | |
| GSE20123 | DECR1 | 1666 | 15 | 1 | 14 | |
| GSE43470 | DECR1 | 1666 | 20 | 1 | 22 | |
| GSE46452 | DECR1 | 1666 | 22 | 0 | 37 | |
| GSE47630 | DECR1 | 1666 | 24 | 0 | 16 | |
| GSE54993 | DECR1 | 1666 | 0 | 20 | 50 | |
| GSE54994 | DECR1 | 1666 | 33 | 1 | 19 | |
| GSE60625 | DECR1 | 1666 | 0 | 4 | 7 | |
| GSE74703 | DECR1 | 1666 | 17 | 1 | 18 | |
| GSE74704 | DECR1 | 1666 | 10 | 0 | 10 | |
| TCGA | DECR1 | 1666 | 56 | 1 | 39 |
Total number of gains: 211; Total number of losses: 30; Total Number of normals: 247.
Somatic mutations of DECR1:
Generating mutation plots.
Highly correlated genes for DECR1:
Showing top 20/835 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DECR1 | MRPL1 | 0.849774 | 3 | 0 | 3 |
| DECR1 | ARG2 | 0.808336 | 3 | 0 | 3 |
| DECR1 | UBR3 | 0.799281 | 3 | 0 | 3 |
| DECR1 | RAD17 | 0.799108 | 4 | 0 | 4 |
| DECR1 | COG3 | 0.77813 | 3 | 0 | 3 |
| DECR1 | COG6 | 0.768686 | 3 | 0 | 3 |
| DECR1 | SLC44A2 | 0.752135 | 3 | 0 | 3 |
| DECR1 | GORASP2 | 0.751794 | 3 | 0 | 3 |
| DECR1 | TMEM167A | 0.744818 | 3 | 0 | 3 |
| DECR1 | COMMD9 | 0.738006 | 3 | 0 | 3 |
| DECR1 | ZNF33A | 0.736304 | 3 | 0 | 3 |
| DECR1 | ALG5 | 0.730321 | 3 | 0 | 3 |
| DECR1 | VPS29 | 0.730282 | 5 | 0 | 5 |
| DECR1 | RNGTT | 0.729083 | 3 | 0 | 3 |
| DECR1 | SEC63 | 0.727214 | 3 | 0 | 3 |
| DECR1 | UBE2E2 | 0.725657 | 3 | 0 | 3 |
| DECR1 | TMEM38A | 0.717629 | 3 | 0 | 3 |
| DECR1 | GFM2 | 0.714707 | 3 | 0 | 3 |
| DECR1 | PPP2R5E | 0.71428 | 3 | 0 | 3 |
| DECR1 | SGK3 | 0.714094 | 3 | 0 | 3 |
For details and further investigation, click here
