| Full name: metallo-beta-lactamase domain containing 2 | Alias Symbol: DKFZp686P15118|MGC46734 | ||
| Type: protein-coding gene | Cytoband: 5q14.3 | ||
| Entrez ID: 153364 | HGNC ID: HGNC:33711 | Ensembl Gene: ENSG00000176055 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of MBLAC2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MBLAC2 | 153364 | 230298_at | 0.0048 | 0.9956 | |
| GSE26886 | MBLAC2 | 153364 | 230298_at | -0.7261 | 0.0400 | |
| GSE45670 | MBLAC2 | 153364 | 230298_at | -0.4828 | 0.0077 | |
| GSE53622 | MBLAC2 | 153364 | 70092 | -0.9701 | 0.0000 | |
| GSE53624 | MBLAC2 | 153364 | 70092 | -0.7032 | 0.0000 | |
| GSE63941 | MBLAC2 | 153364 | 230298_at | -0.5458 | 0.2160 | |
| GSE77861 | MBLAC2 | 153364 | 230298_at | -0.6118 | 0.0076 | |
| GSE97050 | MBLAC2 | 153364 | A_33_P3415663 | -0.2278 | 0.3786 | |
| SRP007169 | MBLAC2 | 153364 | RNAseq | -0.6343 | 0.3775 | |
| SRP008496 | MBLAC2 | 153364 | RNAseq | -0.7268 | 0.1132 | |
| SRP064894 | MBLAC2 | 153364 | RNAseq | -0.7035 | 0.0255 | |
| SRP133303 | MBLAC2 | 153364 | RNAseq | -0.2389 | 0.2262 | |
| SRP159526 | MBLAC2 | 153364 | RNAseq | -0.8786 | 0.0257 | |
| SRP193095 | MBLAC2 | 153364 | RNAseq | -0.8138 | 0.0000 | |
| SRP219564 | MBLAC2 | 153364 | RNAseq | -0.8490 | 0.0447 | |
| TCGA | MBLAC2 | 153364 | RNAseq | -0.0074 | 0.9223 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MBLAC2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MBLAC2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MBLAC2 | 153364 | 1 | 14 | 15 | |
| GSE20123 | MBLAC2 | 153364 | 1 | 14 | 15 | |
| GSE43470 | MBLAC2 | 153364 | 2 | 10 | 31 | |
| GSE46452 | MBLAC2 | 153364 | 0 | 28 | 31 | |
| GSE47630 | MBLAC2 | 153364 | 1 | 20 | 19 | |
| GSE54993 | MBLAC2 | 153364 | 8 | 1 | 61 | |
| GSE54994 | MBLAC2 | 153364 | 1 | 18 | 34 | |
| GSE60625 | MBLAC2 | 153364 | 0 | 0 | 11 | |
| GSE74703 | MBLAC2 | 153364 | 1 | 8 | 27 | |
| GSE74704 | MBLAC2 | 153364 | 1 | 7 | 12 | |
| TCGA | MBLAC2 | 153364 | 2 | 50 | 44 |
Total number of gains: 18; Total number of losses: 170; Total Number of normals: 300.
Somatic mutations of MBLAC2:
Generating mutation plots.
Highly correlated genes for MBLAC2:
Showing top 20/711 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MBLAC2 | NDST1 | 0.782072 | 3 | 0 | 3 |
| MBLAC2 | USP25 | 0.766362 | 4 | 0 | 4 |
| MBLAC2 | FAM172A | 0.765086 | 6 | 0 | 6 |
| MBLAC2 | FBXL3 | 0.753417 | 4 | 0 | 3 |
| MBLAC2 | FBXO10 | 0.743461 | 3 | 0 | 3 |
| MBLAC2 | CTBS | 0.733734 | 4 | 0 | 4 |
| MBLAC2 | ZCCHC10 | 0.724584 | 4 | 0 | 4 |
| MBLAC2 | GABPA | 0.713141 | 6 | 0 | 5 |
| MBLAC2 | CLK1 | 0.711541 | 3 | 0 | 3 |
| MBLAC2 | CETN3 | 0.704606 | 7 | 0 | 6 |
| MBLAC2 | NCKAP1 | 0.702743 | 4 | 0 | 4 |
| MBLAC2 | ZNF614 | 0.700673 | 3 | 0 | 3 |
| MBLAC2 | HFE | 0.699971 | 3 | 0 | 3 |
| MBLAC2 | PGGT1B | 0.699714 | 5 | 0 | 5 |
| MBLAC2 | PIK3C2A | 0.699667 | 5 | 0 | 5 |
| MBLAC2 | RAD17 | 0.698208 | 6 | 0 | 5 |
| MBLAC2 | ACAA1 | 0.698079 | 3 | 0 | 3 |
| MBLAC2 | CPEB3 | 0.698023 | 4 | 0 | 4 |
| MBLAC2 | SLC22A15 | 0.697715 | 3 | 0 | 3 |
| MBLAC2 | ZNF790 | 0.69585 | 3 | 0 | 3 |
For details and further investigation, click here
