| Full name: ring finger protein 125 | Alias Symbol: FLJ20456 | ||
| Type: protein-coding gene | Cytoband: 18q12.1 | ||
| Entrez ID: 54941 | HGNC ID: HGNC:21150 | Ensembl Gene: ENSG00000101695 | OMIM ID: 610432 |
| Drug and gene relationship at DGIdb | |||
RNF125 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04622 | RIG-I-like receptor signaling pathway |
Expression of RNF125:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RNF125 | 54941 | 235199_at | -0.8358 | 0.4155 | |
| GSE20347 | RNF125 | 54941 | 207735_at | -0.6971 | 0.0000 | |
| GSE23400 | RNF125 | 54941 | 207735_at | -0.3635 | 0.0000 | |
| GSE26886 | RNF125 | 54941 | 235199_at | -0.9054 | 0.0084 | |
| GSE29001 | RNF125 | 54941 | 207735_at | -0.1652 | 0.1214 | |
| GSE38129 | RNF125 | 54941 | 207735_at | -0.7387 | 0.0000 | |
| GSE45670 | RNF125 | 54941 | 207735_at | -0.8437 | 0.0001 | |
| GSE53622 | RNF125 | 54941 | 31158 | -1.4658 | 0.0000 | |
| GSE53624 | RNF125 | 54941 | 31158 | -1.2372 | 0.0000 | |
| GSE63941 | RNF125 | 54941 | 235199_at | 0.8572 | 0.3081 | |
| GSE77861 | RNF125 | 54941 | 207735_at | -0.0786 | 0.5253 | |
| GSE97050 | RNF125 | 54941 | A_33_P3257993 | -0.1058 | 0.7043 | |
| SRP007169 | RNF125 | 54941 | RNAseq | -0.5956 | 0.2138 | |
| SRP064894 | RNF125 | 54941 | RNAseq | -0.3582 | 0.2529 | |
| SRP133303 | RNF125 | 54941 | RNAseq | -0.6524 | 0.0001 | |
| SRP159526 | RNF125 | 54941 | RNAseq | -1.2684 | 0.0011 | |
| SRP193095 | RNF125 | 54941 | RNAseq | -0.5436 | 0.0001 | |
| SRP219564 | RNF125 | 54941 | RNAseq | -0.4430 | 0.1443 | |
| TCGA | RNF125 | 54941 | RNAseq | -0.4936 | 0.0013 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by RNF125 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RNF125:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RNF125 | 54941 | 1 | 6 | 23 | |
| GSE20123 | RNF125 | 54941 | 1 | 6 | 23 | |
| GSE43470 | RNF125 | 54941 | 0 | 3 | 40 | |
| GSE46452 | RNF125 | 54941 | 1 | 25 | 33 | |
| GSE47630 | RNF125 | 54941 | 5 | 20 | 15 | |
| GSE54993 | RNF125 | 54941 | 8 | 1 | 61 | |
| GSE54994 | RNF125 | 54941 | 2 | 16 | 35 | |
| GSE60625 | RNF125 | 54941 | 0 | 4 | 7 | |
| GSE74703 | RNF125 | 54941 | 0 | 3 | 33 | |
| GSE74704 | RNF125 | 54941 | 0 | 5 | 15 | |
| TCGA | RNF125 | 54941 | 14 | 36 | 46 |
Total number of gains: 32; Total number of losses: 125; Total Number of normals: 331.
Somatic mutations of RNF125:
Generating mutation plots.
Highly correlated genes for RNF125:
Showing top 20/1084 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RNF125 | FBXL3 | 0.769093 | 4 | 0 | 4 |
| RNF125 | GIMAP5 | 0.765144 | 3 | 0 | 3 |
| RNF125 | MACROD2 | 0.763462 | 3 | 0 | 3 |
| RNF125 | NUB1 | 0.752537 | 4 | 0 | 4 |
| RNF125 | TSPAN31 | 0.752437 | 3 | 0 | 3 |
| RNF125 | ATF6 | 0.740946 | 4 | 0 | 4 |
| RNF125 | FLI1 | 0.738905 | 5 | 0 | 5 |
| RNF125 | USP38 | 0.738683 | 3 | 0 | 3 |
| RNF125 | ARHGAP15 | 0.738272 | 3 | 0 | 3 |
| RNF125 | RERG | 0.733171 | 5 | 0 | 5 |
| RNF125 | KIAA2026 | 0.73123 | 4 | 0 | 4 |
| RNF125 | TMEM219 | 0.731188 | 5 | 0 | 5 |
| RNF125 | UBE2R2 | 0.727487 | 3 | 0 | 3 |
| RNF125 | ALKBH7 | 0.722512 | 5 | 0 | 5 |
| RNF125 | PPM1K | 0.716328 | 5 | 0 | 5 |
| RNF125 | NFKB1 | 0.715737 | 3 | 0 | 3 |
| RNF125 | ARAF | 0.713296 | 3 | 0 | 3 |
| RNF125 | GABPA | 0.71304 | 6 | 0 | 6 |
| RNF125 | PPA1 | 0.71143 | 3 | 0 | 3 |
| RNF125 | KLHDC1 | 0.71109 | 5 | 0 | 5 |
For details and further investigation, click here
