| Full name: helicase, POLQ like | Alias Symbol: Hel308 | ||
| Type: protein-coding gene | Cytoband: 4q21.23 | ||
| Entrez ID: 113510 | HGNC ID: HGNC:18536 | Ensembl Gene: ENSG00000163312 | OMIM ID: 606769 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of HELQ:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HELQ | 113510 | 228736_at | -0.1306 | 0.8018 | |
| GSE26886 | HELQ | 113510 | 228736_at | -0.2377 | 0.4120 | |
| GSE45670 | HELQ | 113510 | 228736_at | -0.2549 | 0.0874 | |
| GSE53622 | HELQ | 113510 | 94232 | -0.3226 | 0.0001 | |
| GSE53624 | HELQ | 113510 | 94232 | -0.2443 | 0.0003 | |
| GSE63941 | HELQ | 113510 | 1554342_s_at | -0.0710 | 0.8720 | |
| GSE77861 | HELQ | 113510 | 1554342_s_at | -0.4458 | 0.0029 | |
| GSE97050 | HELQ | 113510 | A_23_P92614 | 0.0818 | 0.7416 | |
| SRP007169 | HELQ | 113510 | RNAseq | -1.2970 | 0.0028 | |
| SRP008496 | HELQ | 113510 | RNAseq | -1.0841 | 0.0000 | |
| SRP064894 | HELQ | 113510 | RNAseq | -0.4340 | 0.0006 | |
| SRP133303 | HELQ | 113510 | RNAseq | -0.0258 | 0.7881 | |
| SRP159526 | HELQ | 113510 | RNAseq | -0.4080 | 0.0522 | |
| SRP193095 | HELQ | 113510 | RNAseq | -0.2017 | 0.0157 | |
| SRP219564 | HELQ | 113510 | RNAseq | -0.4419 | 0.0512 | |
| TCGA | HELQ | 113510 | RNAseq | -0.1338 | 0.0313 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by HELQ expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HELQ:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HELQ | 113510 | 2 | 11 | 17 | |
| GSE20123 | HELQ | 113510 | 2 | 11 | 17 | |
| GSE43470 | HELQ | 113510 | 0 | 13 | 30 | |
| GSE46452 | HELQ | 113510 | 1 | 36 | 22 | |
| GSE47630 | HELQ | 113510 | 0 | 20 | 20 | |
| GSE54993 | HELQ | 113510 | 8 | 0 | 62 | |
| GSE54994 | HELQ | 113510 | 1 | 9 | 43 | |
| GSE60625 | HELQ | 113510 | 0 | 0 | 11 | |
| GSE74703 | HELQ | 113510 | 0 | 11 | 25 | |
| GSE74704 | HELQ | 113510 | 1 | 6 | 13 | |
| TCGA | HELQ | 113510 | 11 | 34 | 51 |
Total number of gains: 26; Total number of losses: 151; Total Number of normals: 311.
Somatic mutations of HELQ:
Generating mutation plots.
Highly correlated genes for HELQ:
Showing top 20/524 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HELQ | MNS1 | 0.763078 | 3 | 0 | 3 |
| HELQ | NANS | 0.760158 | 3 | 0 | 3 |
| HELQ | COX18 | 0.722691 | 3 | 0 | 3 |
| HELQ | TMEM30B | 0.691151 | 3 | 0 | 3 |
| HELQ | LSS | 0.689561 | 4 | 0 | 3 |
| HELQ | RETSAT | 0.688778 | 3 | 0 | 3 |
| HELQ | FBXO10 | 0.687139 | 3 | 0 | 3 |
| HELQ | MUC20 | 0.68574 | 3 | 0 | 3 |
| HELQ | FRMD4B | 0.681548 | 4 | 0 | 3 |
| HELQ | PEX3 | 0.674246 | 3 | 0 | 3 |
| HELQ | RNF207 | 0.673612 | 3 | 0 | 3 |
| HELQ | ELAC1 | 0.670258 | 4 | 0 | 4 |
| HELQ | PIK3CB | 0.669198 | 4 | 0 | 4 |
| HELQ | PITHD1 | 0.669079 | 5 | 0 | 4 |
| HELQ | STARD10 | 0.668647 | 3 | 0 | 3 |
| HELQ | USP24 | 0.668284 | 3 | 0 | 3 |
| HELQ | SYPL1 | 0.666577 | 4 | 0 | 3 |
| HELQ | PRKAR2A | 0.666207 | 4 | 0 | 3 |
| HELQ | PINK1 | 0.664798 | 3 | 0 | 3 |
| HELQ | N4BP2L1 | 0.662099 | 4 | 0 | 4 |
For details and further investigation, click here
