| Full name: synaptic Ras GTPase activating protein 1 | Alias Symbol: SYNGAP|RASA5|KIAA1938 | ||
| Type: protein-coding gene | Cytoband: 6p21.32 | ||
| Entrez ID: 8831 | HGNC ID: HGNC:11497 | Ensembl Gene: ENSG00000197283 | OMIM ID: 603384 |
| Drug and gene relationship at DGIdb | |||
SYNGAP1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04014 | Ras signaling pathway |
Expression of SYNGAP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SYNGAP1 | 8831 | 230297_x_at | 0.1794 | 0.7532 | |
| GSE26886 | SYNGAP1 | 8831 | 230297_x_at | -0.0226 | 0.9278 | |
| GSE45670 | SYNGAP1 | 8831 | 230297_x_at | -0.0755 | 0.4100 | |
| GSE53622 | SYNGAP1 | 8831 | 26704 | 0.4051 | 0.0000 | |
| GSE53624 | SYNGAP1 | 8831 | 26704 | 0.6270 | 0.0000 | |
| GSE63941 | SYNGAP1 | 8831 | 234285_at | 0.4371 | 0.0157 | |
| GSE77861 | SYNGAP1 | 8831 | 230297_x_at | -0.6071 | 0.0036 | |
| GSE97050 | SYNGAP1 | 8831 | A_24_P9346 | 0.3225 | 0.1882 | |
| SRP007169 | SYNGAP1 | 8831 | RNAseq | 0.8003 | 0.1485 | |
| SRP064894 | SYNGAP1 | 8831 | RNAseq | 0.3651 | 0.1623 | |
| SRP133303 | SYNGAP1 | 8831 | RNAseq | -0.0779 | 0.6561 | |
| SRP159526 | SYNGAP1 | 8831 | RNAseq | -0.1741 | 0.4939 | |
| SRP193095 | SYNGAP1 | 8831 | RNAseq | 0.7687 | 0.0001 | |
| SRP219564 | SYNGAP1 | 8831 | RNAseq | 0.2693 | 0.2230 | |
| TCGA | SYNGAP1 | 8831 | RNAseq | 0.0001 | 0.9983 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SYNGAP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SYNGAP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SYNGAP1 | 8831 | 5 | 0 | 25 | |
| GSE20123 | SYNGAP1 | 8831 | 5 | 0 | 25 | |
| GSE43470 | SYNGAP1 | 8831 | 4 | 1 | 38 | |
| GSE46452 | SYNGAP1 | 8831 | 2 | 9 | 48 | |
| GSE47630 | SYNGAP1 | 8831 | 8 | 4 | 28 | |
| GSE54993 | SYNGAP1 | 8831 | 3 | 1 | 66 | |
| GSE54994 | SYNGAP1 | 8831 | 11 | 4 | 38 | |
| GSE60625 | SYNGAP1 | 8831 | 1 | 0 | 10 | |
| GSE74703 | SYNGAP1 | 8831 | 4 | 0 | 32 | |
| GSE74704 | SYNGAP1 | 8831 | 2 | 0 | 18 | |
| TCGA | SYNGAP1 | 8831 | 15 | 16 | 65 |
Total number of gains: 60; Total number of losses: 35; Total Number of normals: 393.
Somatic mutations of SYNGAP1:
Generating mutation plots.
Highly correlated genes for SYNGAP1:
Showing top 20/315 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SYNGAP1 | SHISA7 | 0.757576 | 3 | 0 | 3 |
| SYNGAP1 | SUN2 | 0.756414 | 3 | 0 | 3 |
| SYNGAP1 | RETN | 0.751446 | 3 | 0 | 3 |
| SYNGAP1 | ZNF341 | 0.742677 | 4 | 0 | 4 |
| SYNGAP1 | MUC8 | 0.739662 | 3 | 0 | 3 |
| SYNGAP1 | SYT3 | 0.736804 | 3 | 0 | 3 |
| SYNGAP1 | PKDREJ | 0.735724 | 3 | 0 | 3 |
| SYNGAP1 | SALL3 | 0.732707 | 3 | 0 | 3 |
| SYNGAP1 | FAM71A | 0.731503 | 3 | 0 | 3 |
| SYNGAP1 | WDR38 | 0.727457 | 3 | 0 | 3 |
| SYNGAP1 | KRT35 | 0.726275 | 4 | 0 | 4 |
| SYNGAP1 | GDPD5 | 0.722041 | 3 | 0 | 3 |
| SYNGAP1 | DPEP3 | 0.719643 | 3 | 0 | 3 |
| SYNGAP1 | TBX21 | 0.719096 | 3 | 0 | 3 |
| SYNGAP1 | TAS2R31 | 0.713328 | 3 | 0 | 3 |
| SYNGAP1 | TAS2R30 | 0.713029 | 3 | 0 | 3 |
| SYNGAP1 | VILL | 0.71291 | 4 | 0 | 3 |
| SYNGAP1 | GPR32 | 0.710267 | 3 | 0 | 3 |
| SYNGAP1 | TBC1D10C | 0.709601 | 3 | 0 | 3 |
| SYNGAP1 | CPAMD8 | 0.706736 | 4 | 0 | 3 |
For details and further investigation, click here
