| Full name: T-box transcription factor 21 | Alias Symbol: TBLYM|T-bet | ||
| Type: protein-coding gene | Cytoband: 17q21.32 | ||
| Entrez ID: 30009 | HGNC ID: HGNC:11599 | Ensembl Gene: ENSG00000073861 | OMIM ID: 604895 |
| Drug and gene relationship at DGIdb | |||
TBX21 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05321 | Inflammatory bowel disease (IBD) |
Expression of TBX21:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TBX21 | 30009 | 220684_at | 0.1141 | 0.7673 | |
| GSE20347 | TBX21 | 30009 | 220684_at | 0.0338 | 0.7385 | |
| GSE23400 | TBX21 | 30009 | 220684_at | -0.0254 | 0.4972 | |
| GSE26886 | TBX21 | 30009 | 220684_at | 0.1297 | 0.2710 | |
| GSE29001 | TBX21 | 30009 | 220684_at | -0.0936 | 0.5598 | |
| GSE38129 | TBX21 | 30009 | 220684_at | -0.0278 | 0.7598 | |
| GSE45670 | TBX21 | 30009 | 220684_at | -0.0190 | 0.8898 | |
| GSE53622 | TBX21 | 30009 | 148553 | -0.2108 | 0.0001 | |
| GSE53624 | TBX21 | 30009 | 148553 | -0.3703 | 0.0000 | |
| GSE63941 | TBX21 | 30009 | 220684_at | 0.0854 | 0.6985 | |
| GSE77861 | TBX21 | 30009 | 220684_at | -0.0862 | 0.3476 | |
| GSE97050 | TBX21 | 30009 | A_23_P141555 | -0.2904 | 0.2361 | |
| SRP133303 | TBX21 | 30009 | RNAseq | -0.5106 | 0.1880 | |
| SRP219564 | TBX21 | 30009 | RNAseq | 0.2642 | 0.6784 | |
| TCGA | TBX21 | 30009 | RNAseq | 0.2983 | 0.4822 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TBX21 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TBX21:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TBX21 | 30009 | 5 | 2 | 23 | |
| GSE20123 | TBX21 | 30009 | 5 | 2 | 23 | |
| GSE43470 | TBX21 | 30009 | 1 | 2 | 40 | |
| GSE46452 | TBX21 | 30009 | 32 | 0 | 27 | |
| GSE47630 | TBX21 | 30009 | 9 | 0 | 31 | |
| GSE54993 | TBX21 | 30009 | 2 | 4 | 64 | |
| GSE54994 | TBX21 | 30009 | 11 | 5 | 37 | |
| GSE60625 | TBX21 | 30009 | 4 | 0 | 7 | |
| GSE74703 | TBX21 | 30009 | 1 | 1 | 34 | |
| GSE74704 | TBX21 | 30009 | 4 | 1 | 15 | |
| TCGA | TBX21 | 30009 | 28 | 6 | 62 |
Total number of gains: 102; Total number of losses: 23; Total Number of normals: 363.
Somatic mutations of TBX21:
Generating mutation plots.
Highly correlated genes for TBX21:
Showing top 20/466 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TBX21 | NUDT13 | 0.815428 | 3 | 0 | 3 |
| TBX21 | CLSTN3 | 0.793039 | 3 | 0 | 3 |
| TBX21 | TFE3 | 0.769668 | 3 | 0 | 3 |
| TBX21 | SLC25A47 | 0.763532 | 3 | 0 | 3 |
| TBX21 | OR2Y1 | 0.758586 | 3 | 0 | 3 |
| TBX21 | MPP3 | 0.758282 | 3 | 0 | 3 |
| TBX21 | TNN | 0.749949 | 4 | 0 | 4 |
| TBX21 | GPHA2 | 0.747394 | 3 | 0 | 3 |
| TBX21 | POLL | 0.740144 | 3 | 0 | 3 |
| TBX21 | SLC18A3 | 0.734835 | 3 | 0 | 3 |
| TBX21 | NPAS1 | 0.725389 | 3 | 0 | 3 |
| TBX21 | IGLON5 | 0.719137 | 3 | 0 | 3 |
| TBX21 | SYNGAP1 | 0.719096 | 3 | 0 | 3 |
| TBX21 | TNNC2 | 0.715046 | 3 | 0 | 3 |
| TBX21 | ESPNL | 0.713005 | 4 | 0 | 4 |
| TBX21 | BATF2 | 0.711342 | 3 | 0 | 3 |
| TBX21 | ZNRF4 | 0.709829 | 5 | 0 | 4 |
| TBX21 | ALX3 | 0.705261 | 3 | 0 | 3 |
| TBX21 | EPHA10 | 0.703118 | 4 | 0 | 3 |
| TBX21 | SP6 | 0.695587 | 4 | 0 | 3 |
For details and further investigation, click here
