| Full name: telomere maintenance 2 | Alias Symbol: KIAA0683|hCLK2|TEL2 | ||
| Type: protein-coding gene | Cytoband: 16p13.3 | ||
| Entrez ID: 9894 | HGNC ID: HGNC:29099 | Ensembl Gene: ENSG00000100726 | OMIM ID: 611140 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
TELO2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa03460 | Fanconi anemia pathway | |
| hsa04150 | mTOR signaling pathway |
Expression of TELO2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TELO2 | 9894 | 34260_at | 0.4954 | 0.1337 | |
| GSE20347 | TELO2 | 9894 | 209528_s_at | 0.1350 | 0.0831 | |
| GSE23400 | TELO2 | 9894 | 34260_at | 0.2010 | 0.0002 | |
| GSE26886 | TELO2 | 9894 | 34260_at | 0.3854 | 0.0151 | |
| GSE29001 | TELO2 | 9894 | 34260_at | 0.4375 | 0.2280 | |
| GSE38129 | TELO2 | 9894 | 209528_s_at | 0.1598 | 0.0424 | |
| GSE45670 | TELO2 | 9894 | 34260_at | 0.3462 | 0.0019 | |
| GSE53622 | TELO2 | 9894 | 74263 | -0.1879 | 0.0000 | |
| GSE53624 | TELO2 | 9894 | 74263 | 0.0302 | 0.5318 | |
| GSE63941 | TELO2 | 9894 | 209528_s_at | 0.1783 | 0.4382 | |
| GSE77861 | TELO2 | 9894 | 34260_at | -0.0537 | 0.7842 | |
| GSE97050 | TELO2 | 9894 | A_33_P3287770 | -0.1830 | 0.3688 | |
| SRP007169 | TELO2 | 9894 | RNAseq | 0.7896 | 0.0996 | |
| SRP008496 | TELO2 | 9894 | RNAseq | 0.2989 | 0.3643 | |
| SRP064894 | TELO2 | 9894 | RNAseq | 0.7171 | 0.0007 | |
| SRP133303 | TELO2 | 9894 | RNAseq | 0.5594 | 0.0032 | |
| SRP159526 | TELO2 | 9894 | RNAseq | 0.1526 | 0.4311 | |
| SRP193095 | TELO2 | 9894 | RNAseq | 0.6329 | 0.0000 | |
| SRP219564 | TELO2 | 9894 | RNAseq | 0.2828 | 0.1953 | |
| TCGA | TELO2 | 9894 | RNAseq | 0.1860 | 0.0007 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TELO2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TELO2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TELO2 | 9894 | 5 | 5 | 20 | |
| GSE20123 | TELO2 | 9894 | 5 | 4 | 21 | |
| GSE43470 | TELO2 | 9894 | 4 | 7 | 32 | |
| GSE46452 | TELO2 | 9894 | 38 | 1 | 20 | |
| GSE47630 | TELO2 | 9894 | 13 | 6 | 21 | |
| GSE54993 | TELO2 | 9894 | 3 | 5 | 62 | |
| GSE54994 | TELO2 | 9894 | 5 | 9 | 39 | |
| GSE60625 | TELO2 | 9894 | 4 | 0 | 7 | |
| GSE74703 | TELO2 | 9894 | 4 | 5 | 27 | |
| GSE74704 | TELO2 | 9894 | 3 | 2 | 15 | |
| TCGA | TELO2 | 9894 | 19 | 15 | 62 |
Total number of gains: 103; Total number of losses: 59; Total Number of normals: 326.
Somatic mutations of TELO2:
Generating mutation plots.
Highly correlated genes for TELO2:
Showing top 20/143 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TELO2 | PDHA1 | 0.749604 | 3 | 0 | 3 |
| TELO2 | ADAMTSL5 | 0.703077 | 3 | 0 | 3 |
| TELO2 | INO80E | 0.699049 | 3 | 0 | 3 |
| TELO2 | B4GALT2 | 0.698694 | 6 | 0 | 6 |
| TELO2 | BAHD1 | 0.690604 | 3 | 0 | 3 |
| TELO2 | ZFP69B | 0.669246 | 4 | 0 | 3 |
| TELO2 | WDR6 | 0.660993 | 3 | 0 | 3 |
| TELO2 | TSGA10IP | 0.654126 | 3 | 0 | 3 |
| TELO2 | MTA1 | 0.645388 | 4 | 0 | 3 |
| TELO2 | SURF2 | 0.639964 | 5 | 0 | 4 |
| TELO2 | MIRLET7BHG | 0.639147 | 3 | 0 | 3 |
| TELO2 | TNNI2 | 0.638923 | 5 | 0 | 4 |
| TELO2 | FAM99B | 0.636781 | 3 | 0 | 3 |
| TELO2 | DCDC2B | 0.635225 | 3 | 0 | 3 |
| TELO2 | TMEM150A | 0.634026 | 3 | 0 | 3 |
| TELO2 | CACNA1H | 0.630265 | 3 | 0 | 3 |
| TELO2 | FAM180B | 0.629674 | 3 | 0 | 3 |
| TELO2 | CC2D1B | 0.628892 | 4 | 0 | 4 |
| TELO2 | SLC52A2 | 0.616775 | 5 | 0 | 4 |
| TELO2 | PVALB | 0.616184 | 4 | 0 | 4 |
For details and further investigation, click here
