| Full name: transforming growth factor alpha | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 2p13.3 | ||
| Entrez ID: 7039 | HGNC ID: HGNC:11765 | Ensembl Gene: ENSG00000163235 | OMIM ID: 190170 |
| Drug and gene relationship at DGIdb | |||
TGFA involved pathways:
Expression of TGFA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TGFA | 7039 | 205016_at | 0.3964 | 0.8109 | |
| GSE20347 | TGFA | 7039 | 205016_at | -0.1188 | 0.7554 | |
| GSE23400 | TGFA | 7039 | 205016_at | -0.1755 | 0.2344 | |
| GSE26886 | TGFA | 7039 | 205016_at | -1.1253 | 0.0009 | |
| GSE29001 | TGFA | 7039 | 205016_at | -0.1096 | 0.8255 | |
| GSE38129 | TGFA | 7039 | 205016_at | 0.8400 | 0.0564 | |
| GSE45670 | TGFA | 7039 | 205016_at | 1.0734 | 0.0001 | |
| GSE53622 | TGFA | 7039 | 5061 | -0.9307 | 0.0000 | |
| GSE53624 | TGFA | 7039 | 5061 | -0.9216 | 0.0000 | |
| GSE63941 | TGFA | 7039 | 205016_at | 4.7707 | 0.0000 | |
| GSE77861 | TGFA | 7039 | 205016_at | 0.1461 | 0.7404 | |
| GSE97050 | TGFA | 7039 | A_33_P3408203 | 0.1995 | 0.8190 | |
| SRP007169 | TGFA | 7039 | RNAseq | -1.0850 | 0.0048 | |
| SRP008496 | TGFA | 7039 | RNAseq | -1.2225 | 0.0002 | |
| SRP064894 | TGFA | 7039 | RNAseq | -0.4359 | 0.2052 | |
| SRP133303 | TGFA | 7039 | RNAseq | 0.3766 | 0.1886 | |
| SRP159526 | TGFA | 7039 | RNAseq | 0.5086 | 0.3694 | |
| SRP193095 | TGFA | 7039 | RNAseq | -0.4213 | 0.1503 | |
| SRP219564 | TGFA | 7039 | RNAseq | -1.1338 | 0.2477 | |
| TCGA | TGFA | 7039 | RNAseq | 0.5396 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 3.
Survival by TGFA expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TGFA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TGFA | 7039 | 11 | 1 | 18 | |
| GSE20123 | TGFA | 7039 | 11 | 1 | 18 | |
| GSE43470 | TGFA | 7039 | 3 | 0 | 40 | |
| GSE46452 | TGFA | 7039 | 2 | 3 | 54 | |
| GSE47630 | TGFA | 7039 | 7 | 0 | 33 | |
| GSE54993 | TGFA | 7039 | 0 | 6 | 64 | |
| GSE54994 | TGFA | 7039 | 11 | 0 | 42 | |
| GSE60625 | TGFA | 7039 | 0 | 3 | 8 | |
| GSE74703 | TGFA | 7039 | 3 | 0 | 33 | |
| GSE74704 | TGFA | 7039 | 9 | 0 | 11 | |
| TCGA | TGFA | 7039 | 36 | 2 | 58 |
Total number of gains: 93; Total number of losses: 16; Total Number of normals: 379.
Somatic mutations of TGFA:
Generating mutation plots.
Highly correlated genes for TGFA:
Showing top 20/390 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TGFA | MFSD2B | 0.771947 | 3 | 0 | 3 |
| TGFA | MUC22 | 0.745425 | 3 | 0 | 3 |
| TGFA | OR2Z1 | 0.734191 | 3 | 0 | 3 |
| TGFA | ZNF165 | 0.73326 | 3 | 0 | 3 |
| TGFA | PKM | 0.71558 | 4 | 0 | 4 |
| TGFA | SERINC5 | 0.705474 | 5 | 0 | 5 |
| TGFA | SNORA71A | 0.702647 | 3 | 0 | 3 |
| TGFA | KRTAP20-1 | 0.698075 | 3 | 0 | 3 |
| TGFA | FAM163B | 0.682581 | 3 | 0 | 3 |
| TGFA | CD164L2 | 0.67505 | 3 | 0 | 3 |
| TGFA | ANKRD31 | 0.673721 | 3 | 0 | 3 |
| TGFA | RNF43 | 0.669543 | 5 | 0 | 4 |
| TGFA | MPZL3 | 0.665404 | 5 | 0 | 5 |
| TGFA | KBTBD13 | 0.665155 | 3 | 0 | 3 |
| TGFA | FAM171A2 | 0.664901 | 3 | 0 | 3 |
| TGFA | DUSP11 | 0.662759 | 6 | 0 | 5 |
| TGFA | FAM83B | 0.662705 | 4 | 0 | 3 |
| TGFA | CLDN24 | 0.656686 | 3 | 0 | 3 |
| TGFA | MYO1D | 0.656485 | 3 | 0 | 3 |
| TGFA | OR10G3 | 0.653553 | 3 | 0 | 3 |
For details and further investigation, click here
