| Full name: pyruvate kinase M1/2 | Alias Symbol: THBP1|OIP3|PK3 | ||
| Type: protein-coding gene | Cytoband: 15q23 | ||
| Entrez ID: 5315 | HGNC ID: HGNC:9021 | Ensembl Gene: ENSG00000067225 | OMIM ID: 179050 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
PKM involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04922 | Glucagon signaling pathway | |
| hsa04930 | Type II diabetes mellitus |
Expression of PKM:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PKM | 5315 | 201251_at | 0.5172 | 0.5231 | |
| GSE20347 | PKM | 5315 | 201251_at | 0.5519 | 0.0416 | |
| GSE23400 | PKM | 5315 | 201251_at | 0.4666 | 0.0000 | |
| GSE26886 | PKM | 5315 | 201251_at | 0.0367 | 0.9389 | |
| GSE29001 | PKM | 5315 | 213700_s_at | 0.4047 | 0.3028 | |
| GSE38129 | PKM | 5315 | 201251_at | 0.6958 | 0.0160 | |
| GSE45670 | PKM | 5315 | 201251_at | 0.5896 | 0.0054 | |
| GSE53622 | PKM | 5315 | 33540 | 0.6778 | 0.0000 | |
| GSE53624 | PKM | 5315 | 33540 | 0.8839 | 0.0000 | |
| GSE63941 | PKM | 5315 | 201251_at | 3.3568 | 0.0000 | |
| GSE77861 | PKM | 5315 | 201251_at | 0.3995 | 0.2525 | |
| SRP007169 | PKM | 5315 | RNAseq | -0.4239 | 0.1528 | |
| SRP008496 | PKM | 5315 | RNAseq | -0.4210 | 0.0699 | |
| SRP064894 | PKM | 5315 | RNAseq | 0.7424 | 0.0001 | |
| SRP133303 | PKM | 5315 | RNAseq | 0.8458 | 0.0004 | |
| SRP159526 | PKM | 5315 | RNAseq | 0.4094 | 0.2878 | |
| SRP193095 | PKM | 5315 | RNAseq | 0.6763 | 0.0007 | |
| SRP219564 | PKM | 5315 | RNAseq | 0.2445 | 0.4950 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by PKM expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of PKM:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PKM | 5315 | 7 | 1 | 22 | |
| GSE20123 | PKM | 5315 | 7 | 1 | 22 | |
| GSE43470 | PKM | 5315 | 4 | 6 | 33 | |
| GSE46452 | PKM | 5315 | 3 | 7 | 49 | |
| GSE47630 | PKM | 5315 | 8 | 10 | 22 | |
| GSE54993 | PKM | 5315 | 5 | 6 | 59 | |
| GSE54994 | PKM | 5315 | 5 | 8 | 40 | |
| GSE60625 | PKM | 5315 | 4 | 4 | 3 | |
| GSE74703 | PKM | 5315 | 4 | 3 | 29 | |
| GSE74704 | PKM | 5315 | 3 | 1 | 16 | |
| TCGA | PKM | 5315 | 12 | 15 | 69 |
Total number of gains: 62; Total number of losses: 62; Total Number of normals: 364.
Somatic mutations of PKM:
Generating mutation plots.
Highly correlated genes for PKM:
Showing top 20/609 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PKM | C2orf81 | 0.716097 | 4 | 0 | 4 |
| PKM | TGFA | 0.71558 | 4 | 0 | 4 |
| PKM | TMEM222 | 0.703128 | 3 | 0 | 3 |
| PKM | MRPL38 | 0.701634 | 3 | 0 | 3 |
| PKM | PFN1 | 0.696165 | 7 | 0 | 6 |
| PKM | LAMA5 | 0.685531 | 3 | 0 | 3 |
| PKM | GPS1 | 0.677909 | 4 | 0 | 3 |
| PKM | SYNGR2 | 0.675755 | 3 | 0 | 3 |
| PKM | ORAI1 | 0.672898 | 3 | 0 | 3 |
| PKM | SEMA4B | 0.67043 | 5 | 0 | 5 |
| PKM | BEST2 | 0.670415 | 3 | 0 | 3 |
| PKM | MKNK1 | 0.670007 | 4 | 0 | 3 |
| PKM | TENM2 | 0.664436 | 5 | 0 | 4 |
| PKM | ZYX | 0.663194 | 4 | 0 | 3 |
| PKM | MYH9 | 0.661906 | 5 | 0 | 4 |
| PKM | ENO1 | 0.654878 | 8 | 0 | 7 |
| PKM | STX1A | 0.652599 | 3 | 0 | 3 |
| PKM | RAC3 | 0.651905 | 3 | 0 | 3 |
| PKM | PLEK2 | 0.650571 | 9 | 0 | 9 |
| PKM | TMEM54 | 0.649923 | 5 | 0 | 5 |
For details and further investigation, click here
