| Full name: ring finger protein 43 | Alias Symbol: FLJ20315|DKFZp781H0392|URCC | ||
| Type: protein-coding gene | Cytoband: 17q23.2 | ||
| Entrez ID: 54894 | HGNC ID: HGNC:18505 | Ensembl Gene: ENSG00000108375 | OMIM ID: 612482 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of RNF43:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RNF43 | 54894 | 218704_at | -0.1036 | 0.8717 | |
| GSE20347 | RNF43 | 54894 | 218704_at | 0.0640 | 0.6980 | |
| GSE23400 | RNF43 | 54894 | 218704_at | -0.0334 | 0.6618 | |
| GSE26886 | RNF43 | 54894 | 218704_at | 0.4939 | 0.1554 | |
| GSE29001 | RNF43 | 54894 | 218704_at | -0.0580 | 0.8911 | |
| GSE38129 | RNF43 | 54894 | 218704_at | 0.3711 | 0.0577 | |
| GSE45670 | RNF43 | 54894 | 218704_at | -0.0226 | 0.9044 | |
| GSE53622 | RNF43 | 54894 | 576 | 0.2100 | 0.3840 | |
| GSE53624 | RNF43 | 54894 | 576 | -0.1810 | 0.0676 | |
| GSE63941 | RNF43 | 54894 | 218704_at | 1.4729 | 0.0193 | |
| GSE77861 | RNF43 | 54894 | 218704_at | 0.3037 | 0.2864 | |
| GSE97050 | RNF43 | 54894 | A_33_P3213029 | 0.3073 | 0.6499 | |
| SRP007169 | RNF43 | 54894 | RNAseq | 0.0776 | 0.8417 | |
| SRP008496 | RNF43 | 54894 | RNAseq | -0.0480 | 0.8733 | |
| SRP064894 | RNF43 | 54894 | RNAseq | -0.4338 | 0.1626 | |
| SRP133303 | RNF43 | 54894 | RNAseq | 0.2682 | 0.4326 | |
| SRP159526 | RNF43 | 54894 | RNAseq | 0.3592 | 0.4205 | |
| SRP193095 | RNF43 | 54894 | RNAseq | -0.2346 | 0.1797 | |
| SRP219564 | RNF43 | 54894 | RNAseq | -0.4247 | 0.6397 | |
| TCGA | RNF43 | 54894 | RNAseq | 0.2885 | 0.0307 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by RNF43 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RNF43:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RNF43 | 54894 | 5 | 1 | 24 | |
| GSE20123 | RNF43 | 54894 | 5 | 1 | 24 | |
| GSE43470 | RNF43 | 54894 | 3 | 0 | 40 | |
| GSE46452 | RNF43 | 54894 | 32 | 0 | 27 | |
| GSE47630 | RNF43 | 54894 | 7 | 1 | 32 | |
| GSE54993 | RNF43 | 54894 | 2 | 5 | 63 | |
| GSE54994 | RNF43 | 54894 | 8 | 6 | 39 | |
| GSE60625 | RNF43 | 54894 | 4 | 0 | 7 | |
| GSE74703 | RNF43 | 54894 | 3 | 0 | 33 | |
| GSE74704 | RNF43 | 54894 | 4 | 1 | 15 | |
| TCGA | RNF43 | 54894 | 27 | 8 | 61 |
Total number of gains: 100; Total number of losses: 23; Total Number of normals: 365.
Somatic mutations of RNF43:
Generating mutation plots.
Highly correlated genes for RNF43:
Showing top 20/69 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RNF43 | HHLA3 | 0.694797 | 3 | 0 | 3 |
| RNF43 | IRF6 | 0.679085 | 4 | 0 | 4 |
| RNF43 | TGFA | 0.669543 | 5 | 0 | 4 |
| RNF43 | PLA2G4F | 0.660213 | 3 | 0 | 3 |
| RNF43 | RAPGEF5 | 0.658343 | 3 | 0 | 3 |
| RNF43 | TANK | 0.640127 | 4 | 0 | 4 |
| RNF43 | LAMA5 | 0.639883 | 4 | 0 | 4 |
| RNF43 | MYH14 | 0.631312 | 4 | 0 | 3 |
| RNF43 | ARHGEF19 | 0.619505 | 3 | 0 | 3 |
| RNF43 | EDAR | 0.618026 | 4 | 0 | 3 |
| RNF43 | TMEM44-AS1 | 0.616388 | 4 | 0 | 3 |
| RNF43 | AP1S3 | 0.615909 | 3 | 0 | 3 |
| RNF43 | SH3TC1 | 0.608109 | 4 | 0 | 3 |
| RNF43 | RSPH4A | 0.604395 | 3 | 0 | 3 |
| RNF43 | ENGASE | 0.603452 | 3 | 0 | 3 |
| RNF43 | FXYD3 | 0.602492 | 4 | 0 | 3 |
| RNF43 | ARHGEF5 | 0.602308 | 5 | 0 | 4 |
| RNF43 | MYO19 | 0.6012 | 4 | 0 | 3 |
| RNF43 | EFNA4 | 0.597037 | 4 | 0 | 3 |
| RNF43 | YWHAE | 0.591019 | 3 | 0 | 3 |
For details and further investigation, click here
