| Full name: serine incorporator 5 | Alias Symbol: TPO1 | ||
| Type: protein-coding gene | Cytoband: 5q14.1 | ||
| Entrez ID: 256987 | HGNC ID: HGNC:18825 | Ensembl Gene: ENSG00000164300 | OMIM ID: 614551 |
| Drug and gene relationship at DGIdb | |||
Expression of SERINC5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SERINC5 | 256987 | 212812_at | -0.1097 | 0.9269 | |
| GSE20347 | SERINC5 | 256987 | 212812_at | -0.5983 | 0.0017 | |
| GSE23400 | SERINC5 | 256987 | 212812_at | -0.1928 | 0.0600 | |
| GSE26886 | SERINC5 | 256987 | 212812_at | -0.7000 | 0.0121 | |
| GSE29001 | SERINC5 | 256987 | 212812_at | -0.4403 | 0.0743 | |
| GSE38129 | SERINC5 | 256987 | 212812_at | -0.0641 | 0.8155 | |
| GSE45670 | SERINC5 | 256987 | 212812_at | 0.1995 | 0.1888 | |
| GSE53622 | SERINC5 | 256987 | 34862 | -0.3941 | 0.0006 | |
| GSE53624 | SERINC5 | 256987 | 34862 | -0.6734 | 0.0000 | |
| GSE63941 | SERINC5 | 256987 | 212812_at | 0.0768 | 0.9095 | |
| GSE77861 | SERINC5 | 256987 | 212812_at | -0.2341 | 0.4036 | |
| GSE97050 | SERINC5 | 256987 | A_23_P423457 | 0.1788 | 0.6490 | |
| SRP007169 | SERINC5 | 256987 | RNAseq | -0.6137 | 0.2436 | |
| SRP008496 | SERINC5 | 256987 | RNAseq | -0.8034 | 0.0208 | |
| SRP064894 | SERINC5 | 256987 | RNAseq | -0.5244 | 0.0406 | |
| SRP133303 | SERINC5 | 256987 | RNAseq | -0.6859 | 0.0000 | |
| SRP159526 | SERINC5 | 256987 | RNAseq | -0.5221 | 0.1355 | |
| SRP193095 | SERINC5 | 256987 | RNAseq | -0.6139 | 0.0000 | |
| SRP219564 | SERINC5 | 256987 | RNAseq | -1.3759 | 0.0243 | |
| TCGA | SERINC5 | 256987 | RNAseq | -0.0728 | 0.5079 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by SERINC5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SERINC5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SERINC5 | 256987 | 1 | 13 | 16 | |
| GSE20123 | SERINC5 | 256987 | 1 | 13 | 16 | |
| GSE43470 | SERINC5 | 256987 | 1 | 11 | 31 | |
| GSE46452 | SERINC5 | 256987 | 0 | 28 | 31 | |
| GSE47630 | SERINC5 | 256987 | 1 | 19 | 20 | |
| GSE54993 | SERINC5 | 256987 | 8 | 1 | 61 | |
| GSE54994 | SERINC5 | 256987 | 2 | 19 | 32 | |
| GSE60625 | SERINC5 | 256987 | 0 | 0 | 11 | |
| GSE74703 | SERINC5 | 256987 | 1 | 7 | 28 | |
| GSE74704 | SERINC5 | 256987 | 1 | 6 | 13 | |
| TCGA | SERINC5 | 256987 | 5 | 49 | 42 |
Total number of gains: 21; Total number of losses: 166; Total Number of normals: 301.
Somatic mutations of SERINC5:
Generating mutation plots.
Highly correlated genes for SERINC5:
Showing top 20/511 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SERINC5 | GJB2 | 0.811041 | 3 | 0 | 3 |
| SERINC5 | AICDA | 0.746549 | 3 | 0 | 3 |
| SERINC5 | TGFA | 0.705474 | 5 | 0 | 5 |
| SERINC5 | HS6ST2 | 0.704581 | 4 | 0 | 4 |
| SERINC5 | SEMA3F | 0.695345 | 6 | 0 | 6 |
| SERINC5 | NEBL | 0.694179 | 9 | 0 | 8 |
| SERINC5 | COG4 | 0.681728 | 3 | 0 | 3 |
| SERINC5 | WDR55 | 0.678044 | 4 | 0 | 3 |
| SERINC5 | OTOP3 | 0.676764 | 3 | 0 | 3 |
| SERINC5 | SDCBP2 | 0.670881 | 3 | 0 | 3 |
| SERINC5 | TEN1 | 0.66901 | 3 | 0 | 3 |
| SERINC5 | TECR | 0.668401 | 8 | 0 | 7 |
| SERINC5 | NUDT8 | 0.666447 | 3 | 0 | 3 |
| SERINC5 | MIXL1 | 0.663961 | 3 | 0 | 3 |
| SERINC5 | NCKAP5 | 0.660913 | 5 | 0 | 3 |
| SERINC5 | ZDHHC13 | 0.66051 | 9 | 0 | 9 |
| SERINC5 | NCCRP1 | 0.658825 | 3 | 0 | 3 |
| SERINC5 | DUOXA2 | 0.654568 | 3 | 0 | 3 |
| SERINC5 | MREG | 0.650551 | 9 | 0 | 8 |
| SERINC5 | SDC1 | 0.650116 | 8 | 0 | 6 |
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