| Full name: T cell leukemia homeobox 3 | Alias Symbol: RNX | ||
| Type: protein-coding gene | Cytoband: 5q35.1 | ||
| Entrez ID: 30012 | HGNC ID: HGNC:13532 | Ensembl Gene: ENSG00000164438 | OMIM ID: 604640 |
| Drug and gene relationship at DGIdb | |||
Expression of TLX3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TLX3 | 30012 | 208495_at | -0.1072 | 0.7262 | |
| GSE20347 | TLX3 | 30012 | 208495_at | -0.1256 | 0.0497 | |
| GSE23400 | TLX3 | 30012 | 208495_at | -0.1160 | 0.0008 | |
| GSE26886 | TLX3 | 30012 | 208495_at | 0.2177 | 0.1482 | |
| GSE29001 | TLX3 | 30012 | 208495_at | -0.1167 | 0.3047 | |
| GSE38129 | TLX3 | 30012 | 208495_at | -0.1433 | 0.0074 | |
| GSE45670 | TLX3 | 30012 | 208495_at | -0.1421 | 0.1157 | |
| GSE63941 | TLX3 | 30012 | 208495_at | 0.5457 | 0.0388 | |
| GSE77861 | TLX3 | 30012 | 208495_at | -0.0255 | 0.8888 | |
| TCGA | TLX3 | 30012 | RNAseq | 4.5500 | 0.0001 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by TLX3 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of TLX3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TLX3 | 30012 | 1 | 13 | 16 | |
| GSE20123 | TLX3 | 30012 | 1 | 13 | 16 | |
| GSE43470 | TLX3 | 30012 | 1 | 11 | 31 | |
| GSE46452 | TLX3 | 30012 | 0 | 27 | 32 | |
| GSE47630 | TLX3 | 30012 | 0 | 20 | 20 | |
| GSE54993 | TLX3 | 30012 | 9 | 2 | 59 | |
| GSE54994 | TLX3 | 30012 | 2 | 15 | 36 | |
| GSE60625 | TLX3 | 30012 | 1 | 0 | 10 | |
| GSE74703 | TLX3 | 30012 | 1 | 7 | 28 | |
| GSE74704 | TLX3 | 30012 | 0 | 6 | 14 | |
| TCGA | TLX3 | 30012 | 8 | 35 | 53 |
Total number of gains: 24; Total number of losses: 149; Total Number of normals: 315.
Somatic mutations of TLX3:
Generating mutation plots.
Highly correlated genes for TLX3:
Showing top 20/426 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TLX3 | RAB4B | 0.699247 | 3 | 0 | 3 |
| TLX3 | FBXL19-AS1 | 0.689518 | 3 | 0 | 3 |
| TLX3 | GSX1 | 0.685074 | 4 | 0 | 4 |
| TLX3 | TNFAIP8L2 | 0.672657 | 3 | 0 | 3 |
| TLX3 | SPATA24 | 0.669759 | 4 | 0 | 4 |
| TLX3 | C2orf81 | 0.669179 | 3 | 0 | 3 |
| TLX3 | MXD3 | 0.661801 | 4 | 0 | 4 |
| TLX3 | HNF1B | 0.656811 | 6 | 0 | 6 |
| TLX3 | MLN | 0.653976 | 3 | 0 | 3 |
| TLX3 | TTLL10 | 0.651187 | 3 | 0 | 3 |
| TLX3 | ROPN1L | 0.648427 | 3 | 0 | 3 |
| TLX3 | SYPL2 | 0.639564 | 3 | 0 | 3 |
| TLX3 | C1QL1 | 0.63597 | 6 | 0 | 5 |
| TLX3 | OLFM1 | 0.635487 | 3 | 0 | 3 |
| TLX3 | TMEM102 | 0.634519 | 3 | 0 | 3 |
| TLX3 | OR10C1 | 0.633985 | 4 | 0 | 3 |
| TLX3 | TRPV5 | 0.632374 | 5 | 0 | 5 |
| TLX3 | EPN1 | 0.628287 | 4 | 0 | 3 |
| TLX3 | NFIA-AS2 | 0.628251 | 4 | 0 | 4 |
| TLX3 | PNOC | 0.626724 | 4 | 0 | 3 |
For details and further investigation, click here
