| Full name: HNF1 homeobox B | Alias Symbol: LFB3|VHNF1|HNF1beta|MODY5 | ||
| Type: protein-coding gene | Cytoband: 17q12 | ||
| Entrez ID: 6928 | HGNC ID: HGNC:11630 | Ensembl Gene: ENSG00000275410 | OMIM ID: 189907 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
HNF1B involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04950 | Maturity onset diabetes of the young |
Expression of HNF1B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HNF1B | 6928 | 205313_at | -0.1064 | 0.7383 | |
| GSE20347 | HNF1B | 6928 | 205313_at | 0.1179 | 0.1593 | |
| GSE23400 | HNF1B | 6928 | 205313_at | -0.0728 | 0.1036 | |
| GSE26886 | HNF1B | 6928 | 205313_at | -0.0522 | 0.7159 | |
| GSE29001 | HNF1B | 6928 | 205313_at | -0.1287 | 0.4014 | |
| GSE38129 | HNF1B | 6928 | 205313_at | -0.0879 | 0.5115 | |
| GSE45670 | HNF1B | 6928 | 205313_at | 0.0215 | 0.8638 | |
| GSE53622 | HNF1B | 6928 | 14467 | -0.1194 | 0.4013 | |
| GSE53624 | HNF1B | 6928 | 14467 | 0.0009 | 0.9935 | |
| GSE63941 | HNF1B | 6928 | 205313_at | 0.4055 | 0.0324 | |
| GSE77861 | HNF1B | 6928 | 205313_at | -0.0506 | 0.7733 | |
| GSE97050 | HNF1B | 6928 | A_24_P330822 | 0.0804 | 0.7659 | |
| TCGA | HNF1B | 6928 | RNAseq | -4.6803 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by HNF1B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HNF1B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HNF1B | 6928 | 6 | 1 | 23 | |
| GSE20123 | HNF1B | 6928 | 6 | 1 | 23 | |
| GSE43470 | HNF1B | 6928 | 2 | 1 | 40 | |
| GSE46452 | HNF1B | 6928 | 34 | 0 | 25 | |
| GSE47630 | HNF1B | 6928 | 8 | 1 | 31 | |
| GSE54993 | HNF1B | 6928 | 3 | 3 | 64 | |
| GSE54994 | HNF1B | 6928 | 8 | 5 | 40 | |
| GSE60625 | HNF1B | 6928 | 4 | 0 | 7 | |
| GSE74703 | HNF1B | 6928 | 1 | 1 | 34 | |
| GSE74704 | HNF1B | 6928 | 3 | 1 | 16 | |
| TCGA | HNF1B | 6928 | 19 | 9 | 68 |
Total number of gains: 94; Total number of losses: 23; Total Number of normals: 371.
Somatic mutations of HNF1B:
Generating mutation plots.
Highly correlated genes for HNF1B:
Showing top 20/940 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HNF1B | LGALS12 | 0.73903 | 3 | 0 | 3 |
| HNF1B | INHBC | 0.727713 | 3 | 0 | 3 |
| HNF1B | TMEM229A | 0.72073 | 3 | 0 | 3 |
| HNF1B | FOXA3 | 0.719086 | 3 | 0 | 3 |
| HNF1B | PRB4 | 0.712268 | 8 | 0 | 8 |
| HNF1B | CLCNKA | 0.707607 | 3 | 0 | 3 |
| HNF1B | HSD3B1 | 0.687443 | 6 | 0 | 6 |
| HNF1B | PNPLA2 | 0.687382 | 10 | 0 | 10 |
| HNF1B | MUC3A | 0.686563 | 3 | 0 | 3 |
| HNF1B | CNGB3 | 0.685566 | 8 | 0 | 7 |
| HNF1B | CACNG4 | 0.682195 | 10 | 0 | 9 |
| HNF1B | TDRD1 | 0.681015 | 5 | 0 | 5 |
| HNF1B | HGD | 0.679733 | 7 | 0 | 7 |
| HNF1B | TBR1 | 0.675798 | 4 | 0 | 3 |
| HNF1B | DSCAM | 0.668949 | 10 | 0 | 9 |
| HNF1B | OTUD5 | 0.668736 | 4 | 0 | 3 |
| HNF1B | USH1C | 0.667994 | 10 | 0 | 9 |
| HNF1B | TMEM221 | 0.667768 | 3 | 0 | 3 |
| HNF1B | SNTG2 | 0.666775 | 4 | 0 | 4 |
| HNF1B | AOC2 | 0.665276 | 3 | 0 | 3 |
For details and further investigation, click here
