| Full name: epsin 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 19q13.42 | ||
| Entrez ID: 29924 | HGNC ID: HGNC:21604 | Ensembl Gene: ENSG00000063245 | OMIM ID: 607262 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of EPN1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EPN1 | 29924 | 226667_x_at | 0.1456 | 0.5204 | |
| GSE20347 | EPN1 | 29924 | 221141_x_at | -0.1342 | 0.0795 | |
| GSE23400 | EPN1 | 29924 | 221141_x_at | -0.1233 | 0.0086 | |
| GSE26886 | EPN1 | 29924 | 226667_x_at | 0.2940 | 0.1088 | |
| GSE29001 | EPN1 | 29924 | 221141_x_at | -0.1314 | 0.4551 | |
| GSE38129 | EPN1 | 29924 | 221141_x_at | -0.2289 | 0.0476 | |
| GSE45670 | EPN1 | 29924 | 221141_x_at | -0.0454 | 0.6764 | |
| GSE53622 | EPN1 | 29924 | 28396 | -0.0812 | 0.1396 | |
| GSE53624 | EPN1 | 29924 | 12248 | -0.1129 | 0.1098 | |
| GSE63941 | EPN1 | 29924 | 226667_x_at | 0.8355 | 0.0000 | |
| GSE77861 | EPN1 | 29924 | 226667_x_at | -0.0015 | 0.9941 | |
| GSE97050 | EPN1 | 29924 | A_33_P3370284 | -0.0104 | 0.9759 | |
| SRP007169 | EPN1 | 29924 | RNAseq | -1.9144 | 0.0000 | |
| SRP008496 | EPN1 | 29924 | RNAseq | -1.7857 | 0.0000 | |
| SRP064894 | EPN1 | 29924 | RNAseq | -0.0512 | 0.8518 | |
| SRP133303 | EPN1 | 29924 | RNAseq | 0.0454 | 0.8230 | |
| SRP159526 | EPN1 | 29924 | RNAseq | -0.0360 | 0.8952 | |
| SRP193095 | EPN1 | 29924 | RNAseq | -0.3852 | 0.0527 | |
| SRP219564 | EPN1 | 29924 | RNAseq | -0.0600 | 0.8308 | |
| TCGA | EPN1 | 29924 | RNAseq | -0.2018 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by EPN1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EPN1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EPN1 | 29924 | 3 | 4 | 23 | |
| GSE20123 | EPN1 | 29924 | 3 | 3 | 24 | |
| GSE43470 | EPN1 | 29924 | 3 | 9 | 31 | |
| GSE46452 | EPN1 | 29924 | 45 | 1 | 13 | |
| GSE47630 | EPN1 | 29924 | 8 | 6 | 26 | |
| GSE54993 | EPN1 | 29924 | 17 | 4 | 49 | |
| GSE54994 | EPN1 | 29924 | 4 | 13 | 36 | |
| GSE60625 | EPN1 | 29924 | 9 | 0 | 2 | |
| GSE74703 | EPN1 | 29924 | 3 | 6 | 27 | |
| GSE74704 | EPN1 | 29924 | 3 | 1 | 16 | |
| TCGA | EPN1 | 29924 | 19 | 15 | 62 |
Total number of gains: 117; Total number of losses: 62; Total Number of normals: 309.
Somatic mutations of EPN1:
Generating mutation plots.
Highly correlated genes for EPN1:
Showing top 20/846 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EPN1 | TNFSF8 | 0.808205 | 3 | 0 | 3 |
| EPN1 | MIER2 | 0.802485 | 5 | 0 | 5 |
| EPN1 | ZNF467 | 0.795748 | 3 | 0 | 3 |
| EPN1 | GABRR2 | 0.794677 | 4 | 0 | 4 |
| EPN1 | PGAP1 | 0.767238 | 3 | 0 | 3 |
| EPN1 | AATK | 0.757124 | 4 | 0 | 4 |
| EPN1 | OGG1 | 0.746488 | 4 | 0 | 4 |
| EPN1 | CDC25A | 0.736942 | 3 | 0 | 3 |
| EPN1 | LARP1 | 0.736556 | 3 | 0 | 3 |
| EPN1 | FAM89B | 0.736048 | 3 | 0 | 3 |
| EPN1 | ZNF771 | 0.735935 | 4 | 0 | 4 |
| EPN1 | SELPLG | 0.735367 | 5 | 0 | 5 |
| EPN1 | RFX2 | 0.733888 | 4 | 0 | 4 |
| EPN1 | CDCA7 | 0.733373 | 3 | 0 | 3 |
| EPN1 | ARHGEF19 | 0.733211 | 3 | 0 | 3 |
| EPN1 | SAMD1 | 0.732226 | 5 | 0 | 5 |
| EPN1 | TMEM212 | 0.730682 | 3 | 0 | 3 |
| EPN1 | REPS1 | 0.730249 | 3 | 0 | 3 |
| EPN1 | EPS15L1 | 0.729858 | 4 | 0 | 4 |
| EPN1 | MRPL38 | 0.729604 | 3 | 0 | 3 |
For details and further investigation, click here
