| Full name: ATP binding cassette subfamily B member 1 | Alias Symbol: P-gp|CD243|GP170|ABC20 | ||
| Type: protein-coding gene | Cytoband: 7q21.12 | ||
| Entrez ID: 5243 | HGNC ID: HGNC:40 | Ensembl Gene: ENSG00000085563 | OMIM ID: 171050 |
| Drug and gene relationship at DGIdb | |||
Expression of ABCB1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ABCB1 | 5243 | 209993_at | -1.0782 | 0.0097 | |
| GSE20347 | ABCB1 | 5243 | 209993_at | -0.2646 | 0.0147 | |
| GSE23400 | ABCB1 | 5243 | 209993_at | -0.1560 | 0.0000 | |
| GSE26886 | ABCB1 | 5243 | 209993_at | -0.0198 | 0.9595 | |
| GSE29001 | ABCB1 | 5243 | 209993_at | -0.2526 | 0.0909 | |
| GSE38129 | ABCB1 | 5243 | 209993_at | -0.4912 | 0.0000 | |
| GSE45670 | ABCB1 | 5243 | 209993_at | -1.7446 | 0.0000 | |
| GSE53622 | ABCB1 | 5243 | 35403 | -0.9183 | 0.0000 | |
| GSE53624 | ABCB1 | 5243 | 153764 | -0.7809 | 0.0000 | |
| GSE63941 | ABCB1 | 5243 | 209993_at | -2.6882 | 0.0001 | |
| GSE77861 | ABCB1 | 5243 | 243951_at | -0.1556 | 0.1151 | |
| GSE97050 | ABCB1 | 5243 | A_33_P3332414 | -0.1539 | 0.4966 | |
| SRP064894 | ABCB1 | 5243 | RNAseq | -1.0671 | 0.0059 | |
| SRP133303 | ABCB1 | 5243 | RNAseq | -1.7494 | 0.0000 | |
| SRP159526 | ABCB1 | 5243 | RNAseq | -1.2426 | 0.0857 | |
| SRP193095 | ABCB1 | 5243 | RNAseq | -1.0328 | 0.0002 | |
| SRP219564 | ABCB1 | 5243 | RNAseq | -1.1138 | 0.0733 | |
| TCGA | ABCB1 | 5243 | RNAseq | -0.9547 | 0.0006 |
Upregulated datasets: 0; Downregulated datasets: 6.
Survival by ABCB1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ABCB1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ABCB1 | 5243 | 13 | 1 | 16 | |
| GSE20123 | ABCB1 | 5243 | 13 | 1 | 16 | |
| GSE43470 | ABCB1 | 5243 | 5 | 1 | 37 | |
| GSE46452 | ABCB1 | 5243 | 12 | 0 | 47 | |
| GSE47630 | ABCB1 | 5243 | 8 | 2 | 30 | |
| GSE54993 | ABCB1 | 5243 | 2 | 7 | 61 | |
| GSE54994 | ABCB1 | 5243 | 17 | 2 | 34 | |
| GSE60625 | ABCB1 | 5243 | 0 | 0 | 11 | |
| GSE74703 | ABCB1 | 5243 | 4 | 1 | 31 | |
| GSE74704 | ABCB1 | 5243 | 9 | 1 | 10 | |
| TCGA | ABCB1 | 5243 | 54 | 4 | 38 |
Total number of gains: 137; Total number of losses: 20; Total Number of normals: 331.
Somatic mutations of ABCB1:
Generating mutation plots.
Highly correlated genes for ABCB1:
Showing top 20/430 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ABCB1 | NCKAP5 | 0.763955 | 3 | 0 | 3 |
| ABCB1 | ASMTL | 0.751366 | 3 | 0 | 3 |
| ABCB1 | ZNF781 | 0.750991 | 3 | 0 | 3 |
| ABCB1 | ADAMTS9-AS2 | 0.742753 | 5 | 0 | 5 |
| ABCB1 | TCEAL7 | 0.724444 | 4 | 0 | 4 |
| ABCB1 | VIT | 0.722692 | 5 | 0 | 5 |
| ABCB1 | SMOC2 | 0.720162 | 4 | 0 | 4 |
| ABCB1 | GALNT15 | 0.718237 | 3 | 0 | 3 |
| ABCB1 | LINC01279 | 0.714577 | 4 | 0 | 3 |
| ABCB1 | RASGRF2 | 0.713552 | 3 | 0 | 3 |
| ABCB1 | GNRH1 | 0.711901 | 3 | 0 | 3 |
| ABCB1 | PDZRN3 | 0.708917 | 7 | 0 | 6 |
| ABCB1 | CREBRF | 0.703774 | 3 | 0 | 3 |
| ABCB1 | MAGI2-AS3 | 0.700648 | 5 | 0 | 4 |
| ABCB1 | MIR100HG | 0.700554 | 5 | 0 | 5 |
| ABCB1 | ZNF763 | 0.700309 | 4 | 0 | 4 |
| ABCB1 | SIRPD | 0.700101 | 3 | 0 | 3 |
| ABCB1 | PTN | 0.698668 | 5 | 0 | 5 |
| ABCB1 | TMEM108 | 0.697713 | 3 | 0 | 3 |
| ABCB1 | TNNI3K | 0.693882 | 3 | 0 | 3 |
For details and further investigation, click here
