| Full name: SPARC related modular calcium binding 2 | Alias Symbol: SMAP2 | ||
| Type: protein-coding gene | Cytoband: 6q27 | ||
| Entrez ID: 64094 | HGNC ID: HGNC:20323 | Ensembl Gene: ENSG00000112562 | OMIM ID: 607223 |
| Drug and gene relationship at DGIdb | |||
Expression of SMOC2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SMOC2 | 64094 | 223235_s_at | -1.8839 | 0.1678 | |
| GSE26886 | SMOC2 | 64094 | 223235_s_at | 1.4609 | 0.0415 | |
| GSE45670 | SMOC2 | 64094 | 223235_s_at | -2.7497 | 0.0000 | |
| GSE53622 | SMOC2 | 64094 | 50050 | -1.2985 | 0.0000 | |
| GSE53624 | SMOC2 | 64094 | 50050 | -1.3559 | 0.0000 | |
| GSE63941 | SMOC2 | 64094 | 223235_s_at | 0.7764 | 0.4564 | |
| GSE77861 | SMOC2 | 64094 | 223235_s_at | 0.5675 | 0.1379 | |
| GSE97050 | SMOC2 | 64094 | A_23_P70307 | -0.6740 | 0.2308 | |
| SRP007169 | SMOC2 | 64094 | RNAseq | 2.9051 | 0.0000 | |
| SRP008496 | SMOC2 | 64094 | RNAseq | 4.7685 | 0.0000 | |
| SRP064894 | SMOC2 | 64094 | RNAseq | -0.6543 | 0.0987 | |
| SRP133303 | SMOC2 | 64094 | RNAseq | -0.7035 | 0.1143 | |
| SRP159526 | SMOC2 | 64094 | RNAseq | 0.0599 | 0.9344 | |
| SRP193095 | SMOC2 | 64094 | RNAseq | 1.6058 | 0.0017 | |
| SRP219564 | SMOC2 | 64094 | RNAseq | -0.3036 | 0.7522 | |
| TCGA | SMOC2 | 64094 | RNAseq | -0.7811 | 0.0001 |
Upregulated datasets: 4; Downregulated datasets: 3.
Survival by SMOC2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SMOC2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SMOC2 | 64094 | 3 | 6 | 21 | |
| GSE20123 | SMOC2 | 64094 | 3 | 6 | 21 | |
| GSE43470 | SMOC2 | 64094 | 3 | 0 | 40 | |
| GSE46452 | SMOC2 | 64094 | 3 | 10 | 46 | |
| GSE47630 | SMOC2 | 64094 | 7 | 7 | 26 | |
| GSE54993 | SMOC2 | 64094 | 4 | 3 | 63 | |
| GSE54994 | SMOC2 | 64094 | 10 | 8 | 35 | |
| GSE60625 | SMOC2 | 64094 | 1 | 1 | 9 | |
| GSE74703 | SMOC2 | 64094 | 3 | 0 | 33 | |
| GSE74704 | SMOC2 | 64094 | 2 | 3 | 15 | |
| TCGA | SMOC2 | 64094 | 14 | 20 | 62 |
Total number of gains: 53; Total number of losses: 64; Total Number of normals: 371.
Somatic mutations of SMOC2:
Generating mutation plots.
Highly correlated genes for SMOC2:
Showing top 20/834 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SMOC2 | BHMT2 | 0.831375 | 5 | 0 | 5 |
| SMOC2 | AQP1 | 0.823177 | 6 | 0 | 6 |
| SMOC2 | ABI3BP | 0.822845 | 5 | 0 | 5 |
| SMOC2 | TNS1 | 0.819632 | 6 | 0 | 6 |
| SMOC2 | PLN | 0.815461 | 7 | 0 | 7 |
| SMOC2 | NEGR1 | 0.813345 | 5 | 0 | 5 |
| SMOC2 | MIR100HG | 0.813103 | 5 | 0 | 5 |
| SMOC2 | DTNA | 0.81154 | 4 | 0 | 4 |
| SMOC2 | ADAMTS8 | 0.807076 | 5 | 0 | 5 |
| SMOC2 | ABCA8 | 0.803843 | 5 | 0 | 5 |
| SMOC2 | OGN | 0.802919 | 5 | 0 | 5 |
| SMOC2 | KCNT2 | 0.802527 | 5 | 0 | 5 |
| SMOC2 | PLCB4 | 0.802212 | 7 | 0 | 7 |
| SMOC2 | TAGLN | 0.799869 | 5 | 0 | 5 |
| SMOC2 | CASQ2 | 0.79862 | 5 | 0 | 5 |
| SMOC2 | CYP21A2 | 0.798091 | 3 | 0 | 3 |
| SMOC2 | CHRDL1 | 0.790944 | 5 | 0 | 5 |
| SMOC2 | ACTG2 | 0.789538 | 7 | 0 | 7 |
| SMOC2 | HSPB7 | 0.788713 | 5 | 0 | 5 |
| SMOC2 | ID4 | 0.786541 | 3 | 0 | 3 |
For details and further investigation, click here
