| Full name: TNNI3 interacting kinase | Alias Symbol: CARK | ||
| Type: protein-coding gene | Cytoband: 1p31.1 | ||
| Entrez ID: 51086 | HGNC ID: HGNC:19661 | Ensembl Gene: ENSG00000116783 | OMIM ID: 613932 |
| Drug and gene relationship at DGIdb | |||
Expression of TNNI3K:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TNNI3K | 51086 | 241858_at | -0.2460 | 0.3490 | |
| GSE26886 | TNNI3K | 51086 | 241858_at | -0.3947 | 0.1481 | |
| GSE45670 | TNNI3K | 51086 | 241858_at | -0.2468 | 0.2239 | |
| GSE63941 | TNNI3K | 51086 | 241858_at | -0.3474 | 0.4364 | |
| GSE77861 | TNNI3K | 51086 | 241858_at | -0.1508 | 0.1459 | |
| GSE97050 | TNNI3K | 51086 | A_24_P415680 | 0.0469 | 0.9554 | |
| TCGA | TNNI3K | 51086 | RNAseq | -1.3737 | 0.0031 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by TNNI3K expression:
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| TCGA |
Note: Click image to view full size file.
Copy number change of TNNI3K:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TNNI3K | 51086 | 1 | 7 | 22 | |
| GSE20123 | TNNI3K | 51086 | 1 | 7 | 22 | |
| GSE43470 | TNNI3K | 51086 | 4 | 2 | 37 | |
| GSE46452 | TNNI3K | 51086 | 0 | 1 | 58 | |
| GSE47630 | TNNI3K | 51086 | 8 | 6 | 26 | |
| GSE54993 | TNNI3K | 51086 | 0 | 0 | 70 | |
| GSE54994 | TNNI3K | 51086 | 6 | 4 | 43 | |
| GSE60625 | TNNI3K | 51086 | 0 | 0 | 11 | |
| GSE74703 | TNNI3K | 51086 | 3 | 2 | 31 | |
| GSE74704 | TNNI3K | 51086 | 1 | 4 | 15 | |
| TCGA | TNNI3K | 51086 | 8 | 24 | 64 |
Total number of gains: 32; Total number of losses: 57; Total Number of normals: 399.
Somatic mutations of TNNI3K:
Generating mutation plots.
Highly correlated genes for TNNI3K:
Showing top 20/30 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TNNI3K | FAM120C | 0.706671 | 3 | 0 | 3 |
| TNNI3K | ABCB1 | 0.693882 | 3 | 0 | 3 |
| TNNI3K | ARL5C | 0.685379 | 3 | 0 | 3 |
| TNNI3K | CATSPER3 | 0.676431 | 3 | 0 | 3 |
| TNNI3K | ROBO2 | 0.672346 | 3 | 0 | 3 |
| TNNI3K | D2HGDH | 0.665873 | 3 | 0 | 3 |
| TNNI3K | PRRG1 | 0.654422 | 3 | 0 | 3 |
| TNNI3K | ZNF677 | 0.648173 | 3 | 0 | 3 |
| TNNI3K | WNT2B | 0.647987 | 3 | 0 | 3 |
| TNNI3K | ATP6AP1L | 0.642951 | 4 | 0 | 3 |
| TNNI3K | FAM189A2 | 0.639823 | 4 | 0 | 3 |
| TNNI3K | ZNF780A | 0.628378 | 4 | 0 | 4 |
| TNNI3K | BTC | 0.620807 | 4 | 0 | 3 |
| TNNI3K | SLC27A6 | 0.613629 | 3 | 0 | 3 |
| TNNI3K | LRRC31 | 0.610756 | 3 | 0 | 3 |
| TNNI3K | NISCH | 0.60078 | 4 | 0 | 4 |
| TNNI3K | NICN1 | 0.600032 | 5 | 0 | 3 |
| TNNI3K | CCDC89 | 0.595813 | 3 | 0 | 3 |
| TNNI3K | RTKN2 | 0.577987 | 3 | 0 | 3 |
| TNNI3K | ABAT | 0.576575 | 4 | 0 | 3 |
For details and further investigation, click here
