GNRH1

 

Full name: gonadotropin releasing hormone 1 Alias Symbol: 
Type: protein-coding gene Cytoband: 8p21.2
Entrez ID: 2796 HGNC ID: HGNC:4419 Ensembl Gene: ENSG00000147437 OMIM ID: 152760
Drug and gene relationship at DGIdb

 

GNRH1 involved pathways:

KEGG pathway Description View
hsa04912GnRH signaling pathway

 

Expression of GNRH1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 GNRH1 2796 207987_s_at -0.0022 0.9959
GSE20347 GNRH1 2796 207987_s_at 0.0609 0.4009
GSE23400 GNRH1 2796 207987_s_at 0.0289 0.1378
GSE26886 GNRH1 2796 207987_s_at 0.0186 0.9278
GSE29001 GNRH1 2796 207987_s_at 0.1721 0.4828
GSE38129 GNRH1 2796 207987_s_at -0.0370 0.6040
GSE45670 GNRH1 2796 207987_s_at 0.0592 0.7032
GSE53622 GNRH1 2796 113287 0.0740 0.4266
GSE53624 GNRH1 2796 113287 -0.0765 0.4605
GSE63941 GNRH1 2796 235540_at -0.5492 0.0628
GSE77861 GNRH1 2796 235540_at 0.1147 0.3417
GSE97050 GNRH1 2796 A_23_P254594 -0.0535 0.8506
SRP064894 GNRH1 2796 RNAseq 0.2923 0.3306
SRP133303 GNRH1 2796 RNAseq -0.7941 0.0030
SRP159526 GNRH1 2796 RNAseq 0.2703 0.7323
SRP193095 GNRH1 2796 RNAseq -0.2248 0.1966
SRP219564 GNRH1 2796 RNAseq -0.1501 0.7459
TCGA GNRH1 2796 RNAseq 0.0948 0.5879

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by GNRH1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of GNRH1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 GNRH1 2796 4 12 14
GSE20123 GNRH1 2796 4 12 14
GSE43470 GNRH1 2796 4 7 32
GSE46452 GNRH1 2796 13 13 33
GSE47630 GNRH1 2796 10 8 22
GSE54993 GNRH1 2796 2 15 53
GSE54994 GNRH1 2796 9 16 28
GSE60625 GNRH1 2796 3 0 8
GSE74703 GNRH1 2796 4 6 26
GSE74704 GNRH1 2796 3 8 9
TCGA GNRH1 2796 15 44 37

Total number of gains: 71; Total number of losses: 141; Total Number of normals: 276.  

 

Somatic mutations of GNRH1:

 

Generating mutation plots.

 

Highly correlated genes for GNRH1:

 

Showing top 20/25 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
GNRH1BAHCC10.768535303
GNRH1NID20.731758303
GNRH1ABCB10.711901303
GNRH1ANKRD33B0.704697303
GNRH1SIRPA0.7014303
GNRH1PMEPA10.699847303
GNRH1PDE6C0.685418303
GNRH1MYO1C0.659478403
GNRH1EML60.633944403
GNRH1COL16A10.630626504
GNRH1SNAI20.617457403
GNRH1NISCH0.613791303
GNRH1OBSL10.606153403
GNRH1MYO100.604896403
GNRH1MOB1B0.604765403
GNRH1FAM131A0.603007403
GNRH1ZNF6670.602499303
GNRH1RAD51-AS10.597932403
GNRH1RBM430.594248403
GNRH1ST8SIA10.589103503

For details and further investigation, click here