| Full name: transmembrane protein 108 | Alias Symbol: MGC3040|CT124 | ||
| Type: protein-coding gene | Cytoband: 3q22.1 | ||
| Entrez ID: 66000 | HGNC ID: HGNC:28451 | Ensembl Gene: ENSG00000144868 | OMIM ID: 617361 |
| Drug and gene relationship at DGIdb | |||
Expression of TMEM108:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TMEM108 | 66000 | 223524_s_at | -0.9341 | 0.5086 | |
| GSE26886 | TMEM108 | 66000 | 234818_at | -0.2166 | 0.0533 | |
| GSE45670 | TMEM108 | 66000 | 223524_s_at | -1.9025 | 0.0000 | |
| GSE53622 | TMEM108 | 66000 | 20485 | -0.1213 | 0.4067 | |
| GSE53624 | TMEM108 | 66000 | 20485 | 0.2220 | 0.0240 | |
| GSE63941 | TMEM108 | 66000 | 234813_at | -0.1210 | 0.4567 | |
| GSE77861 | TMEM108 | 66000 | 234818_at | -0.0992 | 0.4591 | |
| GSE97050 | TMEM108 | 66000 | A_33_P3327462 | -0.0550 | 0.8799 | |
| SRP064894 | TMEM108 | 66000 | RNAseq | -1.5101 | 0.0000 | |
| SRP133303 | TMEM108 | 66000 | RNAseq | -1.1642 | 0.0400 | |
| SRP159526 | TMEM108 | 66000 | RNAseq | 0.7952 | 0.3720 | |
| SRP219564 | TMEM108 | 66000 | RNAseq | -1.7868 | 0.0259 | |
| TCGA | TMEM108 | 66000 | RNAseq | -0.5415 | 0.0446 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by TMEM108 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TMEM108:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TMEM108 | 66000 | 16 | 0 | 14 | |
| GSE20123 | TMEM108 | 66000 | 16 | 0 | 14 | |
| GSE43470 | TMEM108 | 66000 | 21 | 0 | 22 | |
| GSE46452 | TMEM108 | 66000 | 15 | 4 | 40 | |
| GSE47630 | TMEM108 | 66000 | 18 | 3 | 19 | |
| GSE54993 | TMEM108 | 66000 | 2 | 8 | 60 | |
| GSE54994 | TMEM108 | 66000 | 33 | 2 | 18 | |
| GSE60625 | TMEM108 | 66000 | 0 | 6 | 5 | |
| GSE74703 | TMEM108 | 66000 | 18 | 0 | 18 | |
| GSE74704 | TMEM108 | 66000 | 11 | 0 | 9 | |
| TCGA | TMEM108 | 66000 | 59 | 5 | 32 |
Total number of gains: 209; Total number of losses: 28; Total Number of normals: 251.
Somatic mutations of TMEM108:
Generating mutation plots.
Highly correlated genes for TMEM108:
Showing top 20/132 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TMEM108 | CNN1 | 0.754728 | 3 | 0 | 3 |
| TMEM108 | NEURL2 | 0.736338 | 3 | 0 | 3 |
| TMEM108 | SPACA1 | 0.72153 | 3 | 0 | 3 |
| TMEM108 | SV2C | 0.713922 | 3 | 0 | 3 |
| TMEM108 | MITF | 0.710817 | 4 | 0 | 4 |
| TMEM108 | FERD3L | 0.702029 | 3 | 0 | 3 |
| TMEM108 | ABCB1 | 0.697713 | 3 | 0 | 3 |
| TMEM108 | CNTN4 | 0.697635 | 3 | 0 | 3 |
| TMEM108 | DPT | 0.696432 | 4 | 0 | 4 |
| TMEM108 | LINC01082 | 0.696012 | 3 | 0 | 3 |
| TMEM108 | OR2J2 | 0.693255 | 3 | 0 | 3 |
| TMEM108 | KCNQ4 | 0.690501 | 5 | 0 | 5 |
| TMEM108 | DOK7 | 0.690431 | 3 | 0 | 3 |
| TMEM108 | POLL | 0.686965 | 4 | 0 | 3 |
| TMEM108 | EPM2A | 0.686586 | 3 | 0 | 3 |
| TMEM108 | ENPP1 | 0.685064 | 5 | 0 | 4 |
| TMEM108 | THPO | 0.683287 | 3 | 0 | 3 |
| TMEM108 | TEF | 0.682998 | 3 | 0 | 3 |
| TMEM108 | RBMS3 | 0.682214 | 3 | 0 | 3 |
| TMEM108 | MAB21L2 | 0.681366 | 3 | 0 | 3 |
For details and further investigation, click here
