| Full name: Ras protein specific guanine nucleotide releasing factor 2 | Alias Symbol: GRF2|Ras-GRF2 | ||
| Type: protein-coding gene | Cytoband: 5q14.1 | ||
| Entrez ID: 5924 | HGNC ID: HGNC:9876 | Ensembl Gene: ENSG00000113319 | OMIM ID: 606614 |
| Drug and gene relationship at DGIdb | |||
RASGRF2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04010 | MAPK signaling pathway | |
| hsa04014 | Ras signaling pathway |
Expression of RASGRF2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RASGRF2 | 5924 | 1556128_a_at | 0.1130 | 0.7525 | |
| GSE26886 | RASGRF2 | 5924 | 1556128_a_at | -0.1032 | 0.4081 | |
| GSE45670 | RASGRF2 | 5924 | 228109_at | -0.7268 | 0.0030 | |
| GSE53622 | RASGRF2 | 5924 | 29405 | 0.2580 | 0.0009 | |
| GSE53624 | RASGRF2 | 5924 | 29405 | 0.3400 | 0.0000 | |
| GSE63941 | RASGRF2 | 5924 | 1556128_a_at | -1.0617 | 0.0123 | |
| GSE77861 | RASGRF2 | 5924 | 1556128_a_at | -0.0471 | 0.6813 | |
| GSE97050 | RASGRF2 | 5924 | A_23_P133386 | 0.2200 | 0.3653 | |
| SRP007169 | RASGRF2 | 5924 | RNAseq | 2.0034 | 0.0093 | |
| SRP064894 | RASGRF2 | 5924 | RNAseq | 0.8159 | 0.0079 | |
| SRP133303 | RASGRF2 | 5924 | RNAseq | 0.5029 | 0.1009 | |
| SRP159526 | RASGRF2 | 5924 | RNAseq | -0.1237 | 0.6862 | |
| SRP193095 | RASGRF2 | 5924 | RNAseq | 0.2743 | 0.1462 | |
| SRP219564 | RASGRF2 | 5924 | RNAseq | 0.3828 | 0.4050 | |
| TCGA | RASGRF2 | 5924 | RNAseq | -0.2740 | 0.1780 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by RASGRF2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RASGRF2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RASGRF2 | 5924 | 1 | 13 | 16 | |
| GSE20123 | RASGRF2 | 5924 | 1 | 13 | 16 | |
| GSE43470 | RASGRF2 | 5924 | 1 | 11 | 31 | |
| GSE46452 | RASGRF2 | 5924 | 0 | 28 | 31 | |
| GSE47630 | RASGRF2 | 5924 | 1 | 19 | 20 | |
| GSE54993 | RASGRF2 | 5924 | 8 | 1 | 61 | |
| GSE54994 | RASGRF2 | 5924 | 2 | 18 | 33 | |
| GSE60625 | RASGRF2 | 5924 | 0 | 0 | 11 | |
| GSE74703 | RASGRF2 | 5924 | 1 | 7 | 28 | |
| GSE74704 | RASGRF2 | 5924 | 1 | 6 | 13 | |
| TCGA | RASGRF2 | 5924 | 5 | 49 | 42 |
Total number of gains: 21; Total number of losses: 165; Total Number of normals: 302.
Somatic mutations of RASGRF2:
Generating mutation plots.
Highly correlated genes for RASGRF2:
Showing top 20/129 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RASGRF2 | PDZRN3 | 0.774813 | 3 | 0 | 3 |
| RASGRF2 | AMPD2 | 0.765359 | 3 | 0 | 3 |
| RASGRF2 | GSTM5 | 0.756865 | 4 | 0 | 4 |
| RASGRF2 | PLCL2 | 0.748229 | 3 | 0 | 3 |
| RASGRF2 | NID2 | 0.738236 | 4 | 0 | 4 |
| RASGRF2 | CCL13 | 0.736172 | 3 | 0 | 3 |
| RASGRF2 | RAX | 0.730231 | 3 | 0 | 3 |
| RASGRF2 | SCGN | 0.726327 | 4 | 0 | 4 |
| RASGRF2 | KCNMB2 | 0.721481 | 3 | 0 | 3 |
| RASGRF2 | ECM2 | 0.718119 | 3 | 0 | 3 |
| RASGRF2 | CRYGA | 0.714672 | 3 | 0 | 3 |
| RASGRF2 | VCAM1 | 0.714225 | 3 | 0 | 3 |
| RASGRF2 | ABCB1 | 0.713552 | 3 | 0 | 3 |
| RASGRF2 | MAGEE2 | 0.711296 | 3 | 0 | 3 |
| RASGRF2 | FAM110B | 0.710658 | 4 | 0 | 4 |
| RASGRF2 | BAX | 0.707226 | 3 | 0 | 3 |
| RASGRF2 | MAGEL2 | 0.701409 | 3 | 0 | 3 |
| RASGRF2 | GPR26 | 0.693863 | 3 | 0 | 3 |
| RASGRF2 | MAMLD1 | 0.69329 | 4 | 0 | 4 |
| RASGRF2 | B3GALT1 | 0.691577 | 3 | 0 | 3 |
For details and further investigation, click here
