| Full name: PDZ domain containing ring finger 3 | Alias Symbol: KIAA1095|SEMACAP3|LNX3|SEMCAP3 | ||
| Type: protein-coding gene | Cytoband: 3p13 | ||
| Entrez ID: 23024 | HGNC ID: HGNC:17704 | Ensembl Gene: ENSG00000121440 | OMIM ID: 609729 |
| Drug and gene relationship at DGIdb | |||
Expression of PDZRN3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PDZRN3 | 23024 | 212915_at | -2.0891 | 0.0208 | |
| GSE20347 | PDZRN3 | 23024 | 212915_at | -1.0639 | 0.0116 | |
| GSE23400 | PDZRN3 | 23024 | 212915_at | -1.2512 | 0.0000 | |
| GSE26886 | PDZRN3 | 23024 | 212915_at | -2.5721 | 0.0000 | |
| GSE29001 | PDZRN3 | 23024 | 212915_at | -1.9917 | 0.0016 | |
| GSE38129 | PDZRN3 | 23024 | 212915_at | -1.4082 | 0.0002 | |
| GSE45670 | PDZRN3 | 23024 | 212915_at | -1.4799 | 0.0007 | |
| GSE53622 | PDZRN3 | 23024 | 26872 | -0.1967 | 0.0075 | |
| GSE53624 | PDZRN3 | 23024 | 26872 | -0.0705 | 0.4135 | |
| GSE63941 | PDZRN3 | 23024 | 212915_at | -6.9094 | 0.0000 | |
| GSE77861 | PDZRN3 | 23024 | 212915_at | -1.7028 | 0.0037 | |
| GSE97050 | PDZRN3 | 23024 | A_33_P3318490 | -0.2418 | 0.2665 | |
| SRP007169 | PDZRN3 | 23024 | RNAseq | 0.3251 | 0.5403 | |
| SRP064894 | PDZRN3 | 23024 | RNAseq | -0.7305 | 0.0170 | |
| SRP133303 | PDZRN3 | 23024 | RNAseq | -0.5916 | 0.0946 | |
| SRP159526 | PDZRN3 | 23024 | RNAseq | -0.0868 | 0.8904 | |
| SRP193095 | PDZRN3 | 23024 | RNAseq | -0.5532 | 0.0473 | |
| SRP219564 | PDZRN3 | 23024 | RNAseq | -0.7684 | 0.3798 | |
| TCGA | PDZRN3 | 23024 | RNAseq | -0.5921 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 9.
Survival by PDZRN3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PDZRN3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PDZRN3 | 23024 | 1 | 20 | 9 | |
| GSE20123 | PDZRN3 | 23024 | 1 | 20 | 9 | |
| GSE43470 | PDZRN3 | 23024 | 0 | 21 | 22 | |
| GSE46452 | PDZRN3 | 23024 | 2 | 17 | 40 | |
| GSE47630 | PDZRN3 | 23024 | 1 | 23 | 16 | |
| GSE54993 | PDZRN3 | 23024 | 4 | 3 | 63 | |
| GSE54994 | PDZRN3 | 23024 | 1 | 31 | 21 | |
| GSE60625 | PDZRN3 | 23024 | 3 | 1 | 7 | |
| GSE74703 | PDZRN3 | 23024 | 0 | 17 | 19 | |
| GSE74704 | PDZRN3 | 23024 | 1 | 13 | 6 | |
| TCGA | PDZRN3 | 23024 | 1 | 79 | 16 |
Total number of gains: 15; Total number of losses: 245; Total Number of normals: 228.
Somatic mutations of PDZRN3:
Generating mutation plots.
Highly correlated genes for PDZRN3:
Showing top 20/526 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PDZRN3 | ESPNL | 0.853136 | 3 | 0 | 3 |
| PDZRN3 | MAGI2-AS3 | 0.819778 | 3 | 0 | 3 |
| PDZRN3 | OTOG | 0.815844 | 3 | 0 | 3 |
| PDZRN3 | ZNF182 | 0.812757 | 3 | 0 | 3 |
| PDZRN3 | PRSS38 | 0.812344 | 3 | 0 | 3 |
| PDZRN3 | NEGR1 | 0.807689 | 3 | 0 | 3 |
| PDZRN3 | INSC | 0.807549 | 4 | 0 | 4 |
| PDZRN3 | LINC01082 | 0.802258 | 3 | 0 | 3 |
| PDZRN3 | OR2B11 | 0.802135 | 3 | 0 | 3 |
| PDZRN3 | GPR146 | 0.797687 | 3 | 0 | 3 |
| PDZRN3 | CPLX2 | 0.789954 | 3 | 0 | 3 |
| PDZRN3 | NPR2 | 0.7833 | 4 | 0 | 4 |
| PDZRN3 | GDF7 | 0.779838 | 3 | 0 | 3 |
| PDZRN3 | PDZRN3-AS1 | 0.779406 | 5 | 0 | 5 |
| PDZRN3 | RASGRF2 | 0.774813 | 3 | 0 | 3 |
| PDZRN3 | SNORA68 | 0.772682 | 4 | 0 | 4 |
| PDZRN3 | YY2 | 0.771795 | 3 | 0 | 3 |
| PDZRN3 | MIR100HG | 0.768611 | 3 | 0 | 3 |
| PDZRN3 | NCKAP5 | 0.767052 | 4 | 0 | 4 |
| PDZRN3 | SPN | 0.766174 | 3 | 0 | 3 |
For details and further investigation, click here
