ADCY9

 

Full name: adenylate cyclase 9 Alias Symbol: AC9
Type: protein-coding gene Cytoband: 16p13.3
Entrez ID: 115 HGNC ID: HGNC:240 Ensembl Gene: ENSG00000162104 OMIM ID: 603302
Drug and gene relationship at DGIdb

 

ADCY9 involved pathways:

KEGG pathway Description View
hsa04015Rap1 signaling pathway
hsa04020Calcium signaling pathway
hsa04022cGMP-PKG signaling pathway
hsa04024cAMP signaling pathway
hsa04062Chemokine signaling pathway
hsa04072Phospholipase D signaling pathway
hsa04114Oocyte meiosis
hsa04211Longevity regulating pathway - mammal
hsa04213Longevity regulating pathway - multiple species
hsa04261Adrenergic signaling in cardiomyocytes
hsa04270Vascular smooth muscle contraction
hsa04540Gap junction
hsa04611Platelet activation
hsa04713Circadian entrainment
hsa04723Retrograde endocannabinoid signaling
hsa04724Glutamatergic synapse
hsa04725Cholinergic synapse
hsa04727GABAergic synapse
hsa04750Inflammatory mediator regulation of TRP channels
hsa04911Insulin secretion
hsa04912GnRH signaling pathway
hsa04913Ovarian steroidogenesis
hsa04914Progesterone-mediated oocyte maturation
hsa04915Estrogen signaling pathway
hsa04916Melanogenesis
hsa04918Thyroid hormone synthesis
hsa04921Oxytocin signaling pathway
hsa04923Regulation of lipolysis in adipocytes
hsa04925Aldosterone synthesis and secretion
hsa04961Endocrine and other factor-regulated calcium reabsorption
hsa04962Vasopressin-regulated water reabsorption
hsa04970Salivary secretion
hsa04971Gastric acid secretion
hsa04972Pancreatic secretion
hsa04976Bile secretion
hsa05032Morphine addiction
hsa05110Vibrio cholerae infection
hsa05166HTLV-I infection

 

Expression of ADCY9:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ADCY9 115 204497_at -0.6383 0.1963
GSE20347 ADCY9 115 204497_at 0.1563 0.3128
GSE23400 ADCY9 115 204497_at -0.1883 0.0604
GSE26886 ADCY9 115 204497_at 0.5181 0.1720
GSE29001 ADCY9 115 204497_at -0.0758 0.8113
GSE38129 ADCY9 115 204497_at -0.2326 0.4046
GSE45670 ADCY9 115 204497_at -0.3183 0.0535
GSE53622 ADCY9 115 12952 -0.4452 0.0000
GSE53624 ADCY9 115 12952 -0.3336 0.0000
GSE63941 ADCY9 115 204497_at -2.2818 0.0043
GSE77861 ADCY9 115 204497_at 0.0810 0.8797
GSE97050 ADCY9 115 A_24_P935103 -0.5417 0.2144
SRP007169 ADCY9 115 RNAseq -0.1634 0.7587
SRP008496 ADCY9 115 RNAseq -0.2455 0.4078
SRP064894 ADCY9 115 RNAseq -0.5892 0.0015
SRP133303 ADCY9 115 RNAseq -0.0366 0.8534
SRP159526 ADCY9 115 RNAseq 0.1802 0.6881
SRP193095 ADCY9 115 RNAseq -0.0182 0.9162
SRP219564 ADCY9 115 RNAseq -0.1323 0.7316
TCGA ADCY9 115 RNAseq -0.0853 0.1899

Upregulated datasets: 0; Downregulated datasets: 1.  

 

Survival by ADCY9 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ADCY9:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ADCY9 115 5 6 19
GSE20123 ADCY9 115 5 5 20
GSE43470 ADCY9 115 5 6 32
GSE46452 ADCY9 115 38 1 20
GSE47630 ADCY9 115 13 6 21
GSE54993 ADCY9 115 3 5 62
GSE54994 ADCY9 115 5 9 39
GSE60625 ADCY9 115 4 0 7
GSE74703 ADCY9 115 5 4 27
GSE74704 ADCY9 115 3 3 14
TCGA ADCY9 115 19 13 64

Total number of gains: 105; Total number of losses: 58; Total Number of normals: 325.  

 

Somatic mutations of ADCY9:

 

Generating mutation plots.

 

Highly correlated genes for ADCY9:

 

Showing top 20/845 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ADCY9UBXN100.794841303
ADCY9PEG30.738967505
ADCY9FAM122C0.738531303
ADCY9ZNF6550.737725303
ADCY9DOCK110.725978303
ADCY9ABCD20.725412303
ADCY9IQUB0.724405303
ADCY9BRAP0.722403303
ADCY9ITGB1BP20.72116303
ADCY9HOXA40.719373504
ADCY9TNFRSF190.71816303
ADCY9MCAM0.715926605
ADCY9FAM124A0.71499303
ADCY9TMEM980.714946303
ADCY9BCHE0.714283606
ADCY9MMGT10.71014303
ADCY9FXYD10.708702504
ADCY9PRELP0.707881504
ADCY9MAOB0.707576505
ADCY9TLN10.706798505

For details and further investigation, click here