| Full name: butyrylcholinesterase | Alias Symbol: E1 | ||
| Type: protein-coding gene | Cytoband: 3q26.1 | ||
| Entrez ID: 590 | HGNC ID: HGNC:983 | Ensembl Gene: ENSG00000114200 | OMIM ID: 177400 |
| Drug and gene relationship at DGIdb | |||
Expression of BCHE:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | BCHE | 590 | 205433_at | -2.3184 | 0.1486 | |
| GSE20347 | BCHE | 590 | 205433_at | -0.6270 | 0.2909 | |
| GSE23400 | BCHE | 590 | 205433_at | -0.8009 | 0.0056 | |
| GSE26886 | BCHE | 590 | 205433_at | 1.5869 | 0.0199 | |
| GSE29001 | BCHE | 590 | 205433_at | -0.1648 | 0.8313 | |
| GSE38129 | BCHE | 590 | 205433_at | -1.3723 | 0.0193 | |
| GSE45670 | BCHE | 590 | 205433_at | -3.7580 | 0.0000 | |
| GSE53622 | BCHE | 590 | 32103 | -2.1560 | 0.0000 | |
| GSE53624 | BCHE | 590 | 32103 | -2.0090 | 0.0000 | |
| GSE63941 | BCHE | 590 | 205433_at | -0.5823 | 0.8034 | |
| GSE77861 | BCHE | 590 | 205433_at | 0.5548 | 0.4476 | |
| GSE97050 | BCHE | 590 | A_23_P212050 | -1.6255 | 0.1120 | |
| SRP064894 | BCHE | 590 | RNAseq | -0.8566 | 0.0451 | |
| SRP133303 | BCHE | 590 | RNAseq | -0.5272 | 0.5201 | |
| SRP159526 | BCHE | 590 | RNAseq | -0.5619 | 0.3898 | |
| SRP219564 | BCHE | 590 | RNAseq | -0.4044 | 0.7513 | |
| TCGA | BCHE | 590 | RNAseq | -0.4893 | 0.1489 |
Upregulated datasets: 1; Downregulated datasets: 4.
Survival by BCHE expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of BCHE:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | BCHE | 590 | 21 | 0 | 9 | |
| GSE20123 | BCHE | 590 | 21 | 0 | 9 | |
| GSE43470 | BCHE | 590 | 23 | 0 | 20 | |
| GSE46452 | BCHE | 590 | 18 | 2 | 39 | |
| GSE47630 | BCHE | 590 | 27 | 2 | 11 | |
| GSE54993 | BCHE | 590 | 1 | 13 | 56 | |
| GSE54994 | BCHE | 590 | 41 | 0 | 12 | |
| GSE60625 | BCHE | 590 | 0 | 6 | 5 | |
| GSE74703 | BCHE | 590 | 19 | 0 | 17 | |
| GSE74704 | BCHE | 590 | 13 | 0 | 7 | |
| TCGA | BCHE | 590 | 78 | 0 | 18 |
Total number of gains: 262; Total number of losses: 23; Total Number of normals: 203.
Somatic mutations of BCHE:
Generating mutation plots.
Highly correlated genes for BCHE:
Showing top 20/937 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BCHE | ANGPTL1 | 0.841534 | 5 | 0 | 5 |
| BCHE | PPP1R12B | 0.825488 | 8 | 0 | 8 |
| BCHE | ASB5 | 0.821504 | 5 | 0 | 5 |
| BCHE | C1QTNF7 | 0.814574 | 5 | 0 | 5 |
| BCHE | MAMDC2 | 0.81128 | 5 | 0 | 5 |
| BCHE | SLMAP | 0.811252 | 5 | 0 | 5 |
| BCHE | MSRB3 | 0.809258 | 5 | 0 | 5 |
| BCHE | PGR | 0.800184 | 5 | 0 | 5 |
| BCHE | MRVI1 | 0.796173 | 6 | 0 | 6 |
| BCHE | XKR4 | 0.794255 | 5 | 0 | 5 |
| BCHE | PARD3B | 0.792822 | 4 | 0 | 4 |
| BCHE | BHMT2 | 0.789224 | 8 | 0 | 8 |
| BCHE | AQP1 | 0.786798 | 8 | 0 | 8 |
| BCHE | KANK2 | 0.783225 | 8 | 0 | 8 |
| BCHE | LRFN5 | 0.781682 | 4 | 0 | 4 |
| BCHE | RAB9B | 0.781618 | 6 | 0 | 6 |
| BCHE | DIXDC1 | 0.778973 | 8 | 0 | 8 |
| BCHE | CYP21A2 | 0.77896 | 3 | 0 | 3 |
| BCHE | PRUNE2 | 0.775246 | 10 | 0 | 10 |
| BCHE | FLNC | 0.772302 | 9 | 0 | 9 |
For details and further investigation, click here
