| Full name: FXYD domain containing ion transport regulator 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 19q13.12 | ||
| Entrez ID: 5348 | HGNC ID: HGNC:4025 | Ensembl Gene: ENSG00000266964 | OMIM ID: 602359 |
| Drug and gene relationship at DGIdb | |||
FXYD1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04024 | cAMP signaling pathway |
Expression of FXYD1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FXYD1 | 5348 | 205384_at | -1.3655 | 0.0953 | |
| GSE20347 | FXYD1 | 5348 | 205384_at | -0.5227 | 0.0012 | |
| GSE23400 | FXYD1 | 5348 | 205384_at | -0.8777 | 0.0000 | |
| GSE26886 | FXYD1 | 5348 | 205384_at | 0.0587 | 0.6347 | |
| GSE29001 | FXYD1 | 5348 | 205384_at | -0.2854 | 0.0640 | |
| GSE38129 | FXYD1 | 5348 | 205384_at | -1.5129 | 0.0002 | |
| GSE45670 | FXYD1 | 5348 | 205384_at | -0.7547 | 0.0000 | |
| GSE63941 | FXYD1 | 5348 | 205384_at | -0.1928 | 0.2800 | |
| GSE77861 | FXYD1 | 5348 | 205384_at | -0.0368 | 0.8152 | |
| GSE97050 | FXYD1 | 5348 | A_33_P3228435 | -1.1891 | 0.1512 | |
| SRP064894 | FXYD1 | 5348 | RNAseq | -2.2016 | 0.0001 | |
| SRP133303 | FXYD1 | 5348 | RNAseq | -2.9591 | 0.0000 | |
| SRP159526 | FXYD1 | 5348 | RNAseq | -2.2723 | 0.0000 | |
| SRP219564 | FXYD1 | 5348 | RNAseq | -1.8285 | 0.0855 | |
| TCGA | FXYD1 | 5348 | RNAseq | -1.9443 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by FXYD1 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of FXYD1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FXYD1 | 5348 | 6 | 4 | 20 | |
| GSE20123 | FXYD1 | 5348 | 6 | 3 | 21 | |
| GSE43470 | FXYD1 | 5348 | 3 | 7 | 33 | |
| GSE46452 | FXYD1 | 5348 | 48 | 1 | 10 | |
| GSE47630 | FXYD1 | 5348 | 9 | 5 | 26 | |
| GSE54993 | FXYD1 | 5348 | 17 | 3 | 50 | |
| GSE54994 | FXYD1 | 5348 | 8 | 9 | 36 | |
| GSE60625 | FXYD1 | 5348 | 9 | 0 | 2 | |
| GSE74703 | FXYD1 | 5348 | 3 | 4 | 29 | |
| GSE74704 | FXYD1 | 5348 | 6 | 1 | 13 | |
| TCGA | FXYD1 | 5348 | 21 | 11 | 64 |
Total number of gains: 136; Total number of losses: 48; Total Number of normals: 304.
Somatic mutations of FXYD1:
Generating mutation plots.
Highly correlated genes for FXYD1:
Showing top 20/1152 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FXYD1 | PGR | 0.893707 | 3 | 0 | 3 |
| FXYD1 | MAMDC2 | 0.880837 | 3 | 0 | 3 |
| FXYD1 | C1QTNF7 | 0.860155 | 4 | 0 | 4 |
| FXYD1 | NEGR1 | 0.858537 | 4 | 0 | 4 |
| FXYD1 | NEXN | 0.838626 | 3 | 0 | 3 |
| FXYD1 | CYS1 | 0.833324 | 3 | 0 | 3 |
| FXYD1 | EIF4E3 | 0.832167 | 3 | 0 | 3 |
| FXYD1 | FILIP1 | 0.8275 | 3 | 0 | 3 |
| FXYD1 | PTCHD1 | 0.826591 | 3 | 0 | 3 |
| FXYD1 | ITGA7 | 0.825782 | 7 | 0 | 7 |
| FXYD1 | ST6GAL2 | 0.814794 | 3 | 0 | 3 |
| FXYD1 | WFS1 | 0.812311 | 4 | 0 | 4 |
| FXYD1 | ACOX2 | 0.810614 | 6 | 0 | 6 |
| FXYD1 | CBX7 | 0.807498 | 7 | 0 | 7 |
| FXYD1 | PRKAR2B | 0.802011 | 6 | 0 | 6 |
| FXYD1 | SMTN | 0.801964 | 5 | 0 | 5 |
| FXYD1 | RNF150 | 0.797235 | 5 | 0 | 5 |
| FXYD1 | RASSF3 | 0.797179 | 3 | 0 | 3 |
| FXYD1 | ADCY5 | 0.797095 | 3 | 0 | 3 |
| FXYD1 | DPT | 0.796488 | 9 | 0 | 8 |
For details and further investigation, click here
