| Full name: talin 1 | Alias Symbol: ILWEQ | ||
| Type: protein-coding gene | Cytoband: 9p13.3 | ||
| Entrez ID: 7094 | HGNC ID: HGNC:11845 | Ensembl Gene: ENSG00000137076 | OMIM ID: 186745 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
TLN1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04015 | Rap1 signaling pathway | |
| hsa04510 | Focal adhesion | |
| hsa04611 | Platelet activation |
Expression of TLN1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TLN1 | 7094 | 203254_s_at | -0.3529 | 0.7000 | |
| GSE20347 | TLN1 | 7094 | 203254_s_at | 0.0158 | 0.9182 | |
| GSE23400 | TLN1 | 7094 | 203254_s_at | -0.0567 | 0.6951 | |
| GSE26886 | TLN1 | 7094 | 203254_s_at | 0.5036 | 0.0063 | |
| GSE29001 | TLN1 | 7094 | 203254_s_at | 0.0996 | 0.5285 | |
| GSE38129 | TLN1 | 7094 | 203254_s_at | -0.4577 | 0.0473 | |
| GSE45670 | TLN1 | 7094 | 203254_s_at | -0.1307 | 0.1717 | |
| GSE53622 | TLN1 | 7094 | 46580 | -0.3913 | 0.0006 | |
| GSE53624 | TLN1 | 7094 | 46580 | 0.2136 | 0.0095 | |
| GSE63941 | TLN1 | 7094 | 203254_s_at | 0.2470 | 0.5082 | |
| GSE77861 | TLN1 | 7094 | 203254_s_at | 0.0460 | 0.8820 | |
| GSE97050 | TLN1 | 7094 | A_24_P196851 | -0.4346 | 0.3275 | |
| SRP007169 | TLN1 | 7094 | RNAseq | 2.7419 | 0.0000 | |
| SRP008496 | TLN1 | 7094 | RNAseq | 2.7932 | 0.0000 | |
| SRP064894 | TLN1 | 7094 | RNAseq | 0.1149 | 0.5662 | |
| SRP133303 | TLN1 | 7094 | RNAseq | -0.1531 | 0.5866 | |
| SRP159526 | TLN1 | 7094 | RNAseq | -0.6063 | 0.0430 | |
| SRP193095 | TLN1 | 7094 | RNAseq | 0.5895 | 0.0003 | |
| SRP219564 | TLN1 | 7094 | RNAseq | -0.2332 | 0.7383 | |
| TCGA | TLN1 | 7094 | RNAseq | -0.2283 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by TLN1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TLN1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TLN1 | 7094 | 3 | 12 | 15 | |
| GSE20123 | TLN1 | 7094 | 3 | 12 | 15 | |
| GSE43470 | TLN1 | 7094 | 3 | 10 | 30 | |
| GSE46452 | TLN1 | 7094 | 6 | 15 | 38 | |
| GSE47630 | TLN1 | 7094 | 1 | 20 | 19 | |
| GSE54993 | TLN1 | 7094 | 6 | 0 | 64 | |
| GSE54994 | TLN1 | 7094 | 6 | 12 | 35 | |
| GSE60625 | TLN1 | 7094 | 0 | 0 | 11 | |
| GSE74703 | TLN1 | 7094 | 2 | 7 | 27 | |
| GSE74704 | TLN1 | 7094 | 0 | 10 | 10 | |
| TCGA | TLN1 | 7094 | 17 | 44 | 35 |
Total number of gains: 47; Total number of losses: 142; Total Number of normals: 299.
Somatic mutations of TLN1:
Generating mutation plots.
Highly correlated genes for TLN1:
Showing top 20/815 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TLN1 | RGMB | 0.83129 | 3 | 0 | 3 |
| TLN1 | LIMS2 | 0.807103 | 6 | 0 | 6 |
| TLN1 | PRR12 | 0.790129 | 3 | 0 | 3 |
| TLN1 | LPP | 0.789062 | 5 | 0 | 5 |
| TLN1 | ADARB1 | 0.782529 | 6 | 0 | 6 |
| TLN1 | LSM11 | 0.774867 | 3 | 0 | 3 |
| TLN1 | TBX5 | 0.770143 | 3 | 0 | 3 |
| TLN1 | NKX6-1 | 0.767262 | 5 | 0 | 5 |
| TLN1 | ITPKB | 0.765604 | 5 | 0 | 5 |
| TLN1 | C20orf194 | 0.76492 | 3 | 0 | 3 |
| TLN1 | CPXM2 | 0.762164 | 4 | 0 | 4 |
| TLN1 | CCDC136 | 0.761224 | 3 | 0 | 3 |
| TLN1 | FAM160B1 | 0.7589 | 3 | 0 | 3 |
| TLN1 | WSCD2 | 0.757463 | 3 | 0 | 3 |
| TLN1 | ITGB1BP2 | 0.757121 | 3 | 0 | 3 |
| TLN1 | GPM6A | 0.756061 | 4 | 0 | 4 |
| TLN1 | CYP2U1 | 0.75486 | 3 | 0 | 3 |
| TLN1 | PODN | 0.754716 | 3 | 0 | 3 |
| TLN1 | C3orf70 | 0.753101 | 3 | 0 | 3 |
| TLN1 | NHSL2 | 0.75282 | 3 | 0 | 3 |
For details and further investigation, click here
