| Full name: AFG3 like matrix AAA peptidase subunit 2 | Alias Symbol: SPAX5 | ||
| Type: protein-coding gene | Cytoband: 18p11.21 | ||
| Entrez ID: 10939 | HGNC ID: HGNC:315 | Ensembl Gene: ENSG00000141385 | OMIM ID: 604581 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of AFG3L2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AFG3L2 | 10939 | 1557820_at | 0.3877 | 0.5750 | |
| GSE20347 | AFG3L2 | 10939 | 202486_at | 0.2987 | 0.0889 | |
| GSE23400 | AFG3L2 | 10939 | 202486_at | 0.2549 | 0.0013 | |
| GSE26886 | AFG3L2 | 10939 | 1557820_at | 0.0828 | 0.5013 | |
| GSE29001 | AFG3L2 | 10939 | 202486_at | 0.1922 | 0.6062 | |
| GSE38129 | AFG3L2 | 10939 | 202486_at | 0.3154 | 0.0214 | |
| GSE45670 | AFG3L2 | 10939 | 1557820_at | 0.0976 | 0.5328 | |
| GSE63941 | AFG3L2 | 10939 | 1557820_at | 1.1482 | 0.0092 | |
| GSE77861 | AFG3L2 | 10939 | 1557820_at | 0.2709 | 0.1219 | |
| GSE97050 | AFG3L2 | 10939 | A_23_P135454 | 0.1796 | 0.4731 | |
| SRP007169 | AFG3L2 | 10939 | RNAseq | 0.9898 | 0.0070 | |
| SRP008496 | AFG3L2 | 10939 | RNAseq | 0.6308 | 0.0333 | |
| SRP064894 | AFG3L2 | 10939 | RNAseq | -0.1097 | 0.4737 | |
| SRP133303 | AFG3L2 | 10939 | RNAseq | 0.5121 | 0.0970 | |
| SRP159526 | AFG3L2 | 10939 | RNAseq | 0.3142 | 0.2979 | |
| SRP193095 | AFG3L2 | 10939 | RNAseq | -0.1207 | 0.3006 | |
| SRP219564 | AFG3L2 | 10939 | RNAseq | -0.2252 | 0.2688 | |
| TCGA | AFG3L2 | 10939 | RNAseq | -0.0546 | 0.2779 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by AFG3L2 expression:
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| TCGA |
Note: Click image to view full size file.
Copy number change of AFG3L2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AFG3L2 | 10939 | 5 | 3 | 22 | |
| GSE20123 | AFG3L2 | 10939 | 5 | 3 | 22 | |
| GSE43470 | AFG3L2 | 10939 | 0 | 6 | 37 | |
| GSE46452 | AFG3L2 | 10939 | 3 | 21 | 35 | |
| GSE47630 | AFG3L2 | 10939 | 7 | 17 | 16 | |
| GSE54993 | AFG3L2 | 10939 | 6 | 2 | 62 | |
| GSE54994 | AFG3L2 | 10939 | 8 | 8 | 37 | |
| GSE60625 | AFG3L2 | 10939 | 0 | 4 | 7 | |
| GSE74703 | AFG3L2 | 10939 | 0 | 4 | 32 | |
| GSE74704 | AFG3L2 | 10939 | 3 | 2 | 15 | |
| TCGA | AFG3L2 | 10939 | 29 | 23 | 44 |
Total number of gains: 66; Total number of losses: 93; Total Number of normals: 329.
Somatic mutations of AFG3L2:
Generating mutation plots.
Highly correlated genes for AFG3L2:
Showing top 20/442 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AFG3L2 | ZNF607 | 0.718569 | 3 | 0 | 3 |
| AFG3L2 | G2E3 | 0.707421 | 3 | 0 | 3 |
| AFG3L2 | NUDT19 | 0.705056 | 3 | 0 | 3 |
| AFG3L2 | KIAA0895 | 0.699441 | 3 | 0 | 3 |
| AFG3L2 | C1orf131 | 0.690194 | 4 | 0 | 4 |
| AFG3L2 | NR1H3 | 0.689871 | 3 | 0 | 3 |
| AFG3L2 | ARL13B | 0.687327 | 3 | 0 | 3 |
| AFG3L2 | C11orf80 | 0.685118 | 3 | 0 | 3 |
| AFG3L2 | MIPOL1 | 0.684332 | 3 | 0 | 3 |
| AFG3L2 | POLR1B | 0.684252 | 3 | 0 | 3 |
| AFG3L2 | PTGES2 | 0.671396 | 5 | 0 | 5 |
| AFG3L2 | FH | 0.669524 | 3 | 0 | 3 |
| AFG3L2 | DNAJA3 | 0.666986 | 5 | 0 | 5 |
| AFG3L2 | LRRC58 | 0.666228 | 3 | 0 | 3 |
| AFG3L2 | TYSND1 | 0.663615 | 3 | 0 | 3 |
| AFG3L2 | ARV1 | 0.663227 | 3 | 0 | 3 |
| AFG3L2 | C3orf33 | 0.663011 | 4 | 0 | 3 |
| AFG3L2 | PPHLN1 | 0.6627 | 3 | 0 | 3 |
| AFG3L2 | DDIAS | 0.659555 | 3 | 0 | 3 |
| AFG3L2 | NDUFA10 | 0.6594 | 4 | 0 | 4 |
For details and further investigation, click here
