POLR1B

 

Full name: RNA polymerase I subunit B Alias Symbol: Rpo1-2|FLJ21921|FLJ10816|RPA2
Type: protein-coding gene Cytoband: 2q14.1
Entrez ID: 84172 HGNC ID: HGNC:20454 Ensembl Gene: ENSG00000125630 OMIM ID: 602000
Drug and gene relationship at DGIdb

 

Expression of POLR1B:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 POLR1B 84172 223403_s_at 1.3238 0.0792
GSE20347 POLR1B 84172 220113_x_at 0.4080 0.0558
GSE23400 POLR1B 84172 220113_x_at -0.0311 0.7516
GSE26886 POLR1B 84172 223403_s_at 0.7597 0.0001
GSE29001 POLR1B 84172 220113_x_at 0.3059 0.1693
GSE38129 POLR1B 84172 220113_x_at 0.2203 0.3911
GSE45670 POLR1B 84172 223403_s_at 0.7031 0.0000
GSE53622 POLR1B 84172 42253 0.5164 0.0000
GSE53624 POLR1B 84172 42253 0.6451 0.0000
GSE63941 POLR1B 84172 223403_s_at 1.0904 0.0107
GSE77861 POLR1B 84172 220113_x_at 0.6436 0.1581
GSE97050 POLR1B 84172 A_23_P209987 0.5352 0.1453
SRP007169 POLR1B 84172 RNAseq 1.3104 0.0009
SRP008496 POLR1B 84172 RNAseq 1.8448 0.0000
SRP064894 POLR1B 84172 RNAseq -0.0325 0.8594
SRP133303 POLR1B 84172 RNAseq 0.2648 0.1046
SRP159526 POLR1B 84172 RNAseq 0.3809 0.1286
SRP193095 POLR1B 84172 RNAseq 0.2223 0.0298
SRP219564 POLR1B 84172 RNAseq 0.1270 0.6936
TCGA POLR1B 84172 RNAseq 0.1859 0.0010

Upregulated datasets: 3; Downregulated datasets: 0.  

 

Survival by POLR1B expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of POLR1B:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 POLR1B 84172 6 2 22
GSE20123 POLR1B 84172 6 2 22
GSE43470 POLR1B 84172 3 1 39
GSE46452 POLR1B 84172 1 4 54
GSE47630 POLR1B 84172 7 0 33
GSE54993 POLR1B 84172 0 6 64
GSE54994 POLR1B 84172 10 0 43
GSE60625 POLR1B 84172 0 3 8
GSE74703 POLR1B 84172 3 1 32
GSE74704 POLR1B 84172 3 2 15
TCGA POLR1B 84172 31 6 59

Total number of gains: 70; Total number of losses: 27; Total Number of normals: 391.  

 

Somatic mutations of POLR1B:

 

Generating mutation plots.

 

Highly correlated genes for POLR1B:

 

Showing top 20/1377 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
POLR1BSLC35E10.897492707
POLR1BZCCHC70.876561303
POLR1BHAUS20.847139807
POLR1BDDX590.82914303
POLR1BZNF7210.824592807
POLR1BUSP340.821652606
POLR1BANKRD10-IT10.810062605
POLR1BGLRX20.802124303
POLR1BZBTB370.78672303
POLR1BUCK20.785186303
POLR1BMZT2B0.776928907
POLR1BGPATCH20.776572403
POLR1BUBQLN40.775922908
POLR1BSEC61A10.767227404
POLR1BGTF2H30.7659691009
POLR1BOPLAH0.765235303
POLR1BMRPS90.762269404
POLR1BPTPN40.761098504
POLR1BUBA20.75739505
POLR1BALMS10.755718907

For details and further investigation, click here