| Full name: leucine rich repeat containing 58 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 3q13.33 | ||
| Entrez ID: 116064 | HGNC ID: HGNC:26968 | Ensembl Gene: ENSG00000163428 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of LRRC58:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LRRC58 | 116064 | 225479_at | 0.8949 | 0.0623 | |
| GSE26886 | LRRC58 | 116064 | 225479_at | 0.6091 | 0.0002 | |
| GSE45670 | LRRC58 | 116064 | 225479_at | 0.5355 | 0.0011 | |
| GSE63941 | LRRC58 | 116064 | 225479_at | 0.0232 | 0.9708 | |
| GSE77861 | LRRC58 | 116064 | 225479_at | 0.6540 | 0.0126 | |
| GSE97050 | LRRC58 | 116064 | A_32_P190049 | 0.3853 | 0.2082 | |
| SRP007169 | LRRC58 | 116064 | RNAseq | 1.5096 | 0.0000 | |
| SRP008496 | LRRC58 | 116064 | RNAseq | 1.5446 | 0.0000 | |
| SRP064894 | LRRC58 | 116064 | RNAseq | 0.6878 | 0.0004 | |
| SRP133303 | LRRC58 | 116064 | RNAseq | 0.8084 | 0.0000 | |
| SRP159526 | LRRC58 | 116064 | RNAseq | 0.6545 | 0.0201 | |
| SRP193095 | LRRC58 | 116064 | RNAseq | 0.7203 | 0.0000 | |
| SRP219564 | LRRC58 | 116064 | RNAseq | 0.6455 | 0.0141 | |
| TCGA | LRRC58 | 116064 | RNAseq | 0.1352 | 0.0152 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by LRRC58 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of LRRC58:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LRRC58 | 116064 | 18 | 0 | 12 | |
| GSE20123 | LRRC58 | 116064 | 18 | 0 | 12 | |
| GSE43470 | LRRC58 | 116064 | 21 | 1 | 21 | |
| GSE46452 | LRRC58 | 116064 | 14 | 5 | 40 | |
| GSE47630 | LRRC58 | 116064 | 16 | 5 | 19 | |
| GSE54993 | LRRC58 | 116064 | 2 | 6 | 62 | |
| GSE54994 | LRRC58 | 116064 | 30 | 4 | 19 | |
| GSE60625 | LRRC58 | 116064 | 0 | 6 | 5 | |
| GSE74703 | LRRC58 | 116064 | 17 | 1 | 18 | |
| GSE74704 | LRRC58 | 116064 | 13 | 0 | 7 | |
| TCGA | LRRC58 | 116064 | 53 | 7 | 36 |
Total number of gains: 202; Total number of losses: 35; Total Number of normals: 251.
Somatic mutations of LRRC58:
Generating mutation plots.
Highly correlated genes for LRRC58:
Showing top 20/1545 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LRRC58 | UBE2O | 0.855035 | 3 | 0 | 3 |
| LRRC58 | HLTF | 0.849467 | 5 | 0 | 5 |
| LRRC58 | CEP350 | 0.835704 | 3 | 0 | 3 |
| LRRC58 | DBF4 | 0.834997 | 4 | 0 | 4 |
| LRRC58 | RSRC1 | 0.833331 | 5 | 0 | 5 |
| LRRC58 | FLVCR1 | 0.830542 | 4 | 0 | 4 |
| LRRC58 | U2SURP | 0.827715 | 5 | 0 | 5 |
| LRRC58 | MIS18A | 0.826824 | 3 | 0 | 3 |
| LRRC58 | MTBP | 0.826304 | 3 | 0 | 3 |
| LRRC58 | KBTBD6 | 0.825234 | 3 | 0 | 3 |
| LRRC58 | ACTL6A | 0.824456 | 5 | 0 | 5 |
| LRRC58 | ISG20L2 | 0.817742 | 4 | 0 | 4 |
| LRRC58 | COMMD2 | 0.816367 | 4 | 0 | 4 |
| LRRC58 | GGPS1 | 0.81632 | 3 | 0 | 3 |
| LRRC58 | TIMM9 | 0.816161 | 4 | 0 | 4 |
| LRRC58 | RPN1 | 0.8156 | 4 | 0 | 4 |
| LRRC58 | SENP1 | 0.814552 | 3 | 0 | 3 |
| LRRC58 | DNAJC9 | 0.810773 | 3 | 0 | 3 |
| LRRC58 | AURKAIP1 | 0.808638 | 3 | 0 | 3 |
| LRRC58 | CPSF6 | 0.807748 | 5 | 0 | 5 |
For details and further investigation, click here
