| Full name: nuclear receptor subfamily 1 group H member 3 | Alias Symbol: LXR-a|RLD-1|LXRa | ||
| Type: protein-coding gene | Cytoband: 11p11.2 | ||
| Entrez ID: 10062 | HGNC ID: HGNC:7966 | Ensembl Gene: ENSG00000025434 | OMIM ID: 602423 |
| Drug and gene relationship at DGIdb | |||
NR1H3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa03320 | PPAR signaling pathway | |
| hsa04931 | Insulin resistance | |
| hsa04932 | Non-alcoholic fatty liver disease (NAFLD) |
Expression of NR1H3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NR1H3 | 10062 | 203920_at | 0.8007 | 0.3830 | |
| GSE20347 | NR1H3 | 10062 | 203920_at | 0.5540 | 0.0009 | |
| GSE23400 | NR1H3 | 10062 | 203920_at | 0.3666 | 0.0000 | |
| GSE26886 | NR1H3 | 10062 | 203920_at | 0.6669 | 0.0052 | |
| GSE29001 | NR1H3 | 10062 | 203920_at | 0.0627 | 0.7747 | |
| GSE38129 | NR1H3 | 10062 | 203920_at | 0.4044 | 0.1066 | |
| GSE45670 | NR1H3 | 10062 | 203920_at | 0.1862 | 0.4610 | |
| GSE53622 | NR1H3 | 10062 | 1391 | 0.4749 | 0.0002 | |
| GSE53624 | NR1H3 | 10062 | 1391 | 0.7186 | 0.0000 | |
| GSE63941 | NR1H3 | 10062 | 203920_at | 0.5034 | 0.4561 | |
| GSE77861 | NR1H3 | 10062 | 203920_at | 0.2856 | 0.1369 | |
| GSE97050 | NR1H3 | 10062 | A_33_P3237775 | 0.4133 | 0.1798 | |
| SRP007169 | NR1H3 | 10062 | RNAseq | 2.5943 | 0.0058 | |
| SRP064894 | NR1H3 | 10062 | RNAseq | 1.4333 | 0.0001 | |
| SRP133303 | NR1H3 | 10062 | RNAseq | 0.7123 | 0.0013 | |
| SRP159526 | NR1H3 | 10062 | RNAseq | 0.1278 | 0.7306 | |
| SRP193095 | NR1H3 | 10062 | RNAseq | -0.0879 | 0.7887 | |
| SRP219564 | NR1H3 | 10062 | RNAseq | 1.5698 | 0.0083 | |
| TCGA | NR1H3 | 10062 | RNAseq | -0.1560 | 0.1518 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by NR1H3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NR1H3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NR1H3 | 10062 | 3 | 7 | 20 | |
| GSE20123 | NR1H3 | 10062 | 3 | 6 | 21 | |
| GSE43470 | NR1H3 | 10062 | 1 | 4 | 38 | |
| GSE46452 | NR1H3 | 10062 | 8 | 5 | 46 | |
| GSE47630 | NR1H3 | 10062 | 3 | 9 | 28 | |
| GSE54993 | NR1H3 | 10062 | 3 | 0 | 67 | |
| GSE54994 | NR1H3 | 10062 | 1 | 11 | 41 | |
| GSE60625 | NR1H3 | 10062 | 0 | 0 | 11 | |
| GSE74703 | NR1H3 | 10062 | 1 | 2 | 33 | |
| GSE74704 | NR1H3 | 10062 | 2 | 4 | 14 | |
| TCGA | NR1H3 | 10062 | 10 | 20 | 66 |
Total number of gains: 35; Total number of losses: 68; Total Number of normals: 385.
Somatic mutations of NR1H3:
Generating mutation plots.
Highly correlated genes for NR1H3:
Showing top 20/880 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NR1H3 | CRTC2 | 0.808308 | 3 | 0 | 3 |
| NR1H3 | CYHR1 | 0.773202 | 3 | 0 | 3 |
| NR1H3 | ZNF581 | 0.75479 | 3 | 0 | 3 |
| NR1H3 | GLB1L2 | 0.745199 | 3 | 0 | 3 |
| NR1H3 | MSL1 | 0.733419 | 3 | 0 | 3 |
| NR1H3 | GTPBP6 | 0.728556 | 3 | 0 | 3 |
| NR1H3 | TFEC | 0.727086 | 9 | 0 | 9 |
| NR1H3 | PCYT1A | 0.714302 | 3 | 0 | 3 |
| NR1H3 | SNRPD2 | 0.709249 | 4 | 0 | 3 |
| NR1H3 | KDM4A | 0.698242 | 3 | 0 | 3 |
| NR1H3 | CERKL | 0.697552 | 3 | 0 | 3 |
| NR1H3 | SESN3 | 0.693501 | 3 | 0 | 3 |
| NR1H3 | WDR81 | 0.691739 | 4 | 0 | 4 |
| NR1H3 | USP36 | 0.691554 | 3 | 0 | 3 |
| NR1H3 | AFG3L2 | 0.689871 | 3 | 0 | 3 |
| NR1H3 | TNFSF13 | 0.685827 | 7 | 0 | 6 |
| NR1H3 | PDIA5 | 0.685205 | 3 | 0 | 3 |
| NR1H3 | NTPCR | 0.684428 | 3 | 0 | 3 |
| NR1H3 | ZNF397 | 0.684212 | 3 | 0 | 3 |
| NR1H3 | FANCE | 0.682854 | 4 | 0 | 4 |
For details and further investigation, click here
