| Full name: periphilin 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 12q12 | ||
| Entrez ID: 51535 | HGNC ID: HGNC:19369 | Ensembl Gene: ENSG00000134283 | OMIM ID: 608150 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of PPHLN1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PPHLN1 | 51535 | 225073_at | 0.2124 | 0.6582 | |
| GSE26886 | PPHLN1 | 51535 | 225073_at | 0.7110 | 0.0028 | |
| GSE45670 | PPHLN1 | 51535 | 225073_at | 0.0246 | 0.8765 | |
| GSE53622 | PPHLN1 | 51535 | 33367 | 0.2637 | 0.0000 | |
| GSE53624 | PPHLN1 | 51535 | 33367 | 0.3646 | 0.0000 | |
| GSE63941 | PPHLN1 | 51535 | 225073_at | 0.1764 | 0.5721 | |
| GSE77861 | PPHLN1 | 51535 | 225073_at | 0.3794 | 0.3001 | |
| GSE97050 | PPHLN1 | 51535 | A_33_P3368610 | 0.0952 | 0.6607 | |
| SRP007169 | PPHLN1 | 51535 | RNAseq | 1.2850 | 0.0274 | |
| SRP008496 | PPHLN1 | 51535 | RNAseq | 0.9861 | 0.0159 | |
| SRP064894 | PPHLN1 | 51535 | RNAseq | 0.0618 | 0.6444 | |
| SRP133303 | PPHLN1 | 51535 | RNAseq | 0.3538 | 0.0265 | |
| SRP159526 | PPHLN1 | 51535 | RNAseq | -0.0374 | 0.8532 | |
| SRP193095 | PPHLN1 | 51535 | RNAseq | 0.0786 | 0.2922 | |
| SRP219564 | PPHLN1 | 51535 | RNAseq | -0.1216 | 0.5672 | |
| TCGA | PPHLN1 | 51535 | RNAseq | 0.1102 | 0.0291 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by PPHLN1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PPHLN1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PPHLN1 | 51535 | 4 | 1 | 25 | |
| GSE20123 | PPHLN1 | 51535 | 4 | 1 | 25 | |
| GSE43470 | PPHLN1 | 51535 | 4 | 3 | 36 | |
| GSE46452 | PPHLN1 | 51535 | 8 | 1 | 50 | |
| GSE47630 | PPHLN1 | 51535 | 11 | 2 | 27 | |
| GSE54993 | PPHLN1 | 51535 | 0 | 7 | 63 | |
| GSE54994 | PPHLN1 | 51535 | 7 | 3 | 43 | |
| GSE60625 | PPHLN1 | 51535 | 0 | 0 | 11 | |
| GSE74703 | PPHLN1 | 51535 | 3 | 2 | 31 | |
| GSE74704 | PPHLN1 | 51535 | 2 | 1 | 17 | |
| TCGA | PPHLN1 | 51535 | 16 | 15 | 65 |
Total number of gains: 59; Total number of losses: 36; Total Number of normals: 393.
Somatic mutations of PPHLN1:
Generating mutation plots.
Highly correlated genes for PPHLN1:
Showing top 20/826 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PPHLN1 | AP3D1 | 0.834074 | 3 | 0 | 3 |
| PPHLN1 | SEC22A | 0.822162 | 3 | 0 | 3 |
| PPHLN1 | CD44 | 0.799545 | 3 | 0 | 3 |
| PPHLN1 | DAZAP1 | 0.79194 | 3 | 0 | 3 |
| PPHLN1 | ZNF121 | 0.78799 | 3 | 0 | 3 |
| PPHLN1 | PSEN1 | 0.780627 | 3 | 0 | 3 |
| PPHLN1 | IL6R | 0.774247 | 3 | 0 | 3 |
| PPHLN1 | RIMKLB | 0.774163 | 3 | 0 | 3 |
| PPHLN1 | RPL26L1 | 0.773601 | 3 | 0 | 3 |
| PPHLN1 | EXOC8 | 0.767338 | 3 | 0 | 3 |
| PPHLN1 | SMAD1 | 0.766124 | 3 | 0 | 3 |
| PPHLN1 | TBC1D8 | 0.765318 | 3 | 0 | 3 |
| PPHLN1 | POLR2B | 0.763249 | 4 | 0 | 4 |
| PPHLN1 | NCAPG | 0.760961 | 3 | 0 | 3 |
| PPHLN1 | PTBP1 | 0.75929 | 4 | 0 | 4 |
| PPHLN1 | SRSF1 | 0.755473 | 3 | 0 | 3 |
| PPHLN1 | EIF5B | 0.753724 | 4 | 0 | 4 |
| PPHLN1 | KIN | 0.750873 | 3 | 0 | 3 |
| PPHLN1 | KDM5A | 0.75003 | 3 | 0 | 3 |
| PPHLN1 | LRRC40 | 0.747062 | 3 | 0 | 3 |
For details and further investigation, click here
