| Full name: ALX homeobox 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 12q21.31 | ||
| Entrez ID: 8092 | HGNC ID: HGNC:1494 | Ensembl Gene: ENSG00000180318 | OMIM ID: 601527 |
| Drug and gene relationship at DGIdb | |||
Expression of ALX1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ALX1 | 8092 | 206837_at | 0.9639 | 0.1406 | |
| GSE20347 | ALX1 | 8092 | 206837_at | 0.5678 | 0.0362 | |
| GSE23400 | ALX1 | 8092 | 206837_at | 0.0342 | 0.5995 | |
| GSE26886 | ALX1 | 8092 | 206837_at | 0.5518 | 0.0055 | |
| GSE29001 | ALX1 | 8092 | 206837_at | 0.5694 | 0.1166 | |
| GSE38129 | ALX1 | 8092 | 206837_at | 0.5597 | 0.0213 | |
| GSE45670 | ALX1 | 8092 | 206837_at | 0.4152 | 0.1314 | |
| GSE53622 | ALX1 | 8092 | 121990 | 0.4010 | 0.0000 | |
| GSE53624 | ALX1 | 8092 | 121990 | 0.3434 | 0.0006 | |
| GSE63941 | ALX1 | 8092 | 206837_at | 0.7089 | 0.3511 | |
| GSE77861 | ALX1 | 8092 | 206837_at | 0.0471 | 0.6175 | |
| GSE97050 | ALX1 | 8092 | A_23_P83798 | 0.3490 | 0.2910 | |
| SRP007169 | ALX1 | 8092 | RNAseq | 3.5542 | 0.0074 | |
| TCGA | ALX1 | 8092 | RNAseq | 5.5859 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by ALX1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ALX1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ALX1 | 8092 | 3 | 3 | 24 | |
| GSE20123 | ALX1 | 8092 | 3 | 3 | 24 | |
| GSE43470 | ALX1 | 8092 | 3 | 1 | 39 | |
| GSE46452 | ALX1 | 8092 | 9 | 1 | 49 | |
| GSE47630 | ALX1 | 8092 | 10 | 1 | 29 | |
| GSE54993 | ALX1 | 8092 | 0 | 5 | 65 | |
| GSE54994 | ALX1 | 8092 | 7 | 1 | 45 | |
| GSE60625 | ALX1 | 8092 | 0 | 0 | 11 | |
| GSE74703 | ALX1 | 8092 | 3 | 1 | 32 | |
| GSE74704 | ALX1 | 8092 | 1 | 3 | 16 | |
| TCGA | ALX1 | 8092 | 18 | 10 | 68 |
Total number of gains: 57; Total number of losses: 29; Total Number of normals: 402.
Somatic mutations of ALX1:
Generating mutation plots.
Highly correlated genes for ALX1:
Showing top 20/136 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ALX1 | ACTR3B | 0.858056 | 3 | 0 | 3 |
| ALX1 | TP53BP1 | 0.834101 | 3 | 0 | 3 |
| ALX1 | IER5L | 0.779911 | 3 | 0 | 3 |
| ALX1 | LRFN4 | 0.749415 | 4 | 0 | 3 |
| ALX1 | GNB1L | 0.746193 | 3 | 0 | 3 |
| ALX1 | TMEM182 | 0.743599 | 3 | 0 | 3 |
| ALX1 | OR1F1 | 0.736423 | 3 | 0 | 3 |
| ALX1 | MS4A18 | 0.724966 | 3 | 0 | 3 |
| ALX1 | C1QL2 | 0.721034 | 3 | 0 | 3 |
| ALX1 | CADPS | 0.718287 | 3 | 0 | 3 |
| ALX1 | HHATL | 0.715796 | 3 | 0 | 3 |
| ALX1 | SNORA71A | 0.71241 | 3 | 0 | 3 |
| ALX1 | TAS2R39 | 0.708423 | 3 | 0 | 3 |
| ALX1 | UBE2S | 0.706913 | 3 | 0 | 3 |
| ALX1 | KCNC3 | 0.706905 | 3 | 0 | 3 |
| ALX1 | OR2D3 | 0.706663 | 3 | 0 | 3 |
| ALX1 | MRGPRG | 0.697658 | 3 | 0 | 3 |
| ALX1 | CHP2 | 0.696797 | 4 | 0 | 3 |
| ALX1 | KLK3 | 0.694233 | 3 | 0 | 3 |
| ALX1 | LYZL2 | 0.693339 | 3 | 0 | 3 |
For details and further investigation, click here
