| Full name: leucine rich repeat and fibronectin type III domain containing 4 | Alias Symbol: MGC3103|SALM3.|FIGLER6 | ||
| Type: protein-coding gene | Cytoband: 11q13.1 | ||
| Entrez ID: 78999 | HGNC ID: HGNC:28456 | Ensembl Gene: ENSG00000173621 | OMIM ID: 612810 |
| Drug and gene relationship at DGIdb | |||
Expression of LRFN4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LRFN4 | 78999 | 219491_at | 1.2666 | 0.0768 | |
| GSE20347 | LRFN4 | 78999 | 219491_at | 0.8763 | 0.0000 | |
| GSE23400 | LRFN4 | 78999 | 219491_at | 0.5489 | 0.0000 | |
| GSE26886 | LRFN4 | 78999 | 238092_at | -0.0046 | 0.9794 | |
| GSE29001 | LRFN4 | 78999 | 219491_at | 1.1054 | 0.0013 | |
| GSE38129 | LRFN4 | 78999 | 219491_at | 0.7694 | 0.0000 | |
| GSE45670 | LRFN4 | 78999 | 238092_at | 0.0188 | 0.8532 | |
| GSE53622 | LRFN4 | 78999 | 73556 | 0.8995 | 0.0000 | |
| GSE53624 | LRFN4 | 78999 | 73556 | 0.9183 | 0.0000 | |
| GSE63941 | LRFN4 | 78999 | 238092_at | 0.3604 | 0.0269 | |
| GSE77861 | LRFN4 | 78999 | 238092_at | -0.0145 | 0.9387 | |
| GSE97050 | LRFN4 | 78999 | A_23_P63980 | 0.3450 | 0.2076 | |
| SRP007169 | LRFN4 | 78999 | RNAseq | 1.9659 | 0.0006 | |
| SRP008496 | LRFN4 | 78999 | RNAseq | 1.9494 | 0.0000 | |
| SRP064894 | LRFN4 | 78999 | RNAseq | 1.6108 | 0.0000 | |
| SRP133303 | LRFN4 | 78999 | RNAseq | 1.6854 | 0.0000 | |
| SRP159526 | LRFN4 | 78999 | RNAseq | 2.1837 | 0.0000 | |
| SRP193095 | LRFN4 | 78999 | RNAseq | 1.5283 | 0.0000 | |
| SRP219564 | LRFN4 | 78999 | RNAseq | 1.1846 | 0.0062 | |
| TCGA | LRFN4 | 78999 | RNAseq | 0.6454 | 0.0000 |
Upregulated datasets: 8; Downregulated datasets: 0.
Survival by LRFN4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LRFN4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LRFN4 | 78999 | 9 | 3 | 18 | |
| GSE20123 | LRFN4 | 78999 | 9 | 3 | 18 | |
| GSE43470 | LRFN4 | 78999 | 6 | 1 | 36 | |
| GSE46452 | LRFN4 | 78999 | 12 | 3 | 44 | |
| GSE47630 | LRFN4 | 78999 | 9 | 4 | 27 | |
| GSE54993 | LRFN4 | 78999 | 3 | 0 | 67 | |
| GSE54994 | LRFN4 | 78999 | 10 | 7 | 36 | |
| GSE60625 | LRFN4 | 78999 | 0 | 3 | 8 | |
| GSE74703 | LRFN4 | 78999 | 4 | 0 | 32 | |
| GSE74704 | LRFN4 | 78999 | 7 | 1 | 12 | |
| TCGA | LRFN4 | 78999 | 26 | 8 | 62 |
Total number of gains: 95; Total number of losses: 33; Total Number of normals: 360.
Somatic mutations of LRFN4:
Generating mutation plots.
Highly correlated genes for LRFN4:
Showing top 20/702 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LRFN4 | MS4A18 | 0.831551 | 3 | 0 | 3 |
| LRFN4 | RLN3 | 0.797161 | 3 | 0 | 3 |
| LRFN4 | ABCC6 | 0.794799 | 3 | 0 | 3 |
| LRFN4 | COL27A1 | 0.788345 | 4 | 0 | 4 |
| LRFN4 | ALKBH2 | 0.780745 | 3 | 0 | 3 |
| LRFN4 | NTNG2 | 0.780728 | 4 | 0 | 4 |
| LRFN4 | ZNF646 | 0.777 | 3 | 0 | 3 |
| LRFN4 | NEUROG1 | 0.76353 | 3 | 0 | 3 |
| LRFN4 | RASL10A | 0.758018 | 3 | 0 | 3 |
| LRFN4 | SMPD4 | 0.757555 | 3 | 0 | 3 |
| LRFN4 | CC2D1B | 0.757106 | 4 | 0 | 4 |
| LRFN4 | RHBDD3 | 0.751619 | 5 | 0 | 5 |
| LRFN4 | ALX1 | 0.749415 | 4 | 0 | 3 |
| LRFN4 | C2CD4D | 0.746422 | 3 | 0 | 3 |
| LRFN4 | GPSM3 | 0.741454 | 3 | 0 | 3 |
| LRFN4 | TCHHL1 | 0.740049 | 3 | 0 | 3 |
| LRFN4 | OR7D4 | 0.737638 | 3 | 0 | 3 |
| LRFN4 | MRGPRG | 0.736114 | 3 | 0 | 3 |
| LRFN4 | SP7 | 0.735857 | 3 | 0 | 3 |
| LRFN4 | LHB | 0.732375 | 3 | 0 | 3 |
For details and further investigation, click here
