| Full name: G protein subunit beta 1 like | Alias Symbol: GY2|WDR14 | ||
| Type: protein-coding gene | Cytoband: 22q11.21 | ||
| Entrez ID: 54584 | HGNC ID: HGNC:4397 | Ensembl Gene: ENSG00000185838 | OMIM ID: 610778 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of GNB1L:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GNB1L | 54584 | 220762_s_at | 0.4269 | 0.2842 | |
| GSE20347 | GNB1L | 54584 | 220762_s_at | 0.0713 | 0.3876 | |
| GSE23400 | GNB1L | 54584 | 220762_s_at | 0.0401 | 0.3263 | |
| GSE26886 | GNB1L | 54584 | 220762_s_at | 0.8507 | 0.0000 | |
| GSE29001 | GNB1L | 54584 | 220762_s_at | 0.1537 | 0.3227 | |
| GSE38129 | GNB1L | 54584 | 220762_s_at | 0.2780 | 0.0016 | |
| GSE45670 | GNB1L | 54584 | 220762_s_at | 0.3090 | 0.0106 | |
| GSE53622 | GNB1L | 54584 | 28868 | 0.4456 | 0.0000 | |
| GSE53624 | GNB1L | 54584 | 28868 | 0.8770 | 0.0000 | |
| GSE63941 | GNB1L | 54584 | 220762_s_at | 0.3597 | 0.2427 | |
| GSE77861 | GNB1L | 54584 | 220762_s_at | 0.1597 | 0.3283 | |
| GSE97050 | GNB1L | 54584 | A_23_P218751 | 0.1709 | 0.4831 | |
| SRP007169 | GNB1L | 54584 | RNAseq | 1.3716 | 0.0836 | |
| SRP064894 | GNB1L | 54584 | RNAseq | 1.0136 | 0.0026 | |
| SRP133303 | GNB1L | 54584 | RNAseq | 0.6950 | 0.0011 | |
| SRP159526 | GNB1L | 54584 | RNAseq | 0.4663 | 0.0757 | |
| SRP193095 | GNB1L | 54584 | RNAseq | 1.0596 | 0.0000 | |
| SRP219564 | GNB1L | 54584 | RNAseq | 0.7638 | 0.0284 | |
| TCGA | GNB1L | 54584 | RNAseq | 0.6464 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by GNB1L expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GNB1L:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GNB1L | 54584 | 5 | 7 | 18 | |
| GSE20123 | GNB1L | 54584 | 5 | 7 | 18 | |
| GSE43470 | GNB1L | 54584 | 4 | 7 | 32 | |
| GSE46452 | GNB1L | 54584 | 33 | 1 | 25 | |
| GSE47630 | GNB1L | 54584 | 8 | 5 | 27 | |
| GSE54993 | GNB1L | 54584 | 3 | 6 | 61 | |
| GSE54994 | GNB1L | 54584 | 12 | 7 | 34 | |
| GSE60625 | GNB1L | 54584 | 5 | 0 | 6 | |
| GSE74703 | GNB1L | 54584 | 4 | 5 | 27 | |
| GSE74704 | GNB1L | 54584 | 3 | 4 | 13 | |
| TCGA | GNB1L | 54584 | 27 | 17 | 52 |
Total number of gains: 109; Total number of losses: 66; Total Number of normals: 313.
Somatic mutations of GNB1L:
Generating mutation plots.
Highly correlated genes for GNB1L:
Showing top 20/377 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GNB1L | ALX1 | 0.746193 | 3 | 0 | 3 |
| GNB1L | ZNF526 | 0.737458 | 3 | 0 | 3 |
| GNB1L | FBXL15 | 0.731433 | 3 | 0 | 3 |
| GNB1L | C7orf26 | 0.725524 | 3 | 0 | 3 |
| GNB1L | DPM3 | 0.712095 | 4 | 0 | 3 |
| GNB1L | ASTN2 | 0.684028 | 4 | 0 | 4 |
| GNB1L | TP53BP1 | 0.679584 | 6 | 0 | 5 |
| GNB1L | HOXC9 | 0.678665 | 5 | 0 | 4 |
| GNB1L | CDK12 | 0.669276 | 3 | 0 | 3 |
| GNB1L | VPS37D | 0.663488 | 4 | 0 | 4 |
| GNB1L | CORT | 0.663151 | 4 | 0 | 3 |
| GNB1L | AIFM3 | 0.657968 | 5 | 0 | 4 |
| GNB1L | APBA3 | 0.656692 | 3 | 0 | 3 |
| GNB1L | SLC35G1 | 0.653883 | 3 | 0 | 3 |
| GNB1L | POP7 | 0.653541 | 7 | 0 | 7 |
| GNB1L | ERC2 | 0.650486 | 4 | 0 | 3 |
| GNB1L | CALML6 | 0.648523 | 3 | 0 | 3 |
| GNB1L | ZKSCAN2 | 0.648094 | 3 | 0 | 3 |
| GNB1L | EFNB1 | 0.647682 | 7 | 0 | 6 |
| GNB1L | TLR9 | 0.644949 | 3 | 0 | 3 |
For details and further investigation, click here
