| Full name: ubiquitin conjugating enzyme E2 S | Alias Symbol: E2-EPF | ||
| Type: protein-coding gene | Cytoband: 19q13.43 | ||
| Entrez ID: 27338 | HGNC ID: HGNC:17895 | Ensembl Gene: ENSG00000108106 | OMIM ID: 610309 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of UBE2S:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | UBE2S | 27338 | 202779_s_at | 1.2900 | 0.0088 | |
| GSE20347 | UBE2S | 27338 | 202779_s_at | 1.1073 | 0.0001 | |
| GSE23400 | UBE2S | 27338 | 202779_s_at | 1.1180 | 0.0000 | |
| GSE26886 | UBE2S | 27338 | 202779_s_at | 0.9865 | 0.0010 | |
| GSE29001 | UBE2S | 27338 | 202779_s_at | 0.5721 | 0.0715 | |
| GSE38129 | UBE2S | 27338 | 202779_s_at | 1.5734 | 0.0000 | |
| GSE45670 | UBE2S | 27338 | 202779_s_at | 0.9887 | 0.0009 | |
| GSE63941 | UBE2S | 27338 | 202779_s_at | 2.0644 | 0.0006 | |
| GSE77861 | UBE2S | 27338 | 202779_s_at | 1.1875 | 0.0040 | |
| GSE97050 | UBE2S | 27338 | A_32_P171328 | 0.4363 | 0.2419 | |
| SRP007169 | UBE2S | 27338 | RNAseq | 0.3665 | 0.3129 | |
| SRP008496 | UBE2S | 27338 | RNAseq | 0.5533 | 0.0471 | |
| SRP064894 | UBE2S | 27338 | RNAseq | 1.7008 | 0.0001 | |
| SRP133303 | UBE2S | 27338 | RNAseq | 1.7044 | 0.0000 | |
| SRP159526 | UBE2S | 27338 | RNAseq | 1.9061 | 0.0000 | |
| SRP193095 | UBE2S | 27338 | RNAseq | 1.1240 | 0.0000 | |
| SRP219564 | UBE2S | 27338 | RNAseq | 0.8138 | 0.0559 | |
| TCGA | UBE2S | 27338 | RNAseq | 0.8539 | 0.0000 |
Upregulated datasets: 10; Downregulated datasets: 0.
Survival by UBE2S expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of UBE2S:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | UBE2S | 27338 | 3 | 4 | 23 | |
| GSE20123 | UBE2S | 27338 | 3 | 3 | 24 | |
| GSE43470 | UBE2S | 27338 | 3 | 11 | 29 | |
| GSE46452 | UBE2S | 27338 | 45 | 1 | 13 | |
| GSE47630 | UBE2S | 27338 | 8 | 6 | 26 | |
| GSE54993 | UBE2S | 27338 | 17 | 4 | 49 | |
| GSE54994 | UBE2S | 27338 | 4 | 13 | 36 | |
| GSE60625 | UBE2S | 27338 | 9 | 0 | 2 | |
| GSE74703 | UBE2S | 27338 | 3 | 7 | 26 | |
| GSE74704 | UBE2S | 27338 | 3 | 1 | 16 | |
| TCGA | UBE2S | 27338 | 20 | 14 | 62 |
Total number of gains: 118; Total number of losses: 64; Total Number of normals: 306.
Somatic mutations of UBE2S:
Generating mutation plots.
Highly correlated genes for UBE2S:
Showing top 20/575 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| UBE2S | UBE2T | 0.839483 | 5 | 0 | 5 |
| UBE2S | DBF4B | 0.795839 | 3 | 0 | 3 |
| UBE2S | SLC4A11 | 0.769401 | 3 | 0 | 3 |
| UBE2S | KIF4A | 0.766773 | 9 | 0 | 9 |
| UBE2S | CDCA8 | 0.766447 | 8 | 0 | 8 |
| UBE2S | CDCA5 | 0.7651 | 6 | 0 | 6 |
| UBE2S | CKS1B | 0.761139 | 9 | 0 | 9 |
| UBE2S | HAUS8 | 0.758224 | 6 | 0 | 6 |
| UBE2S | FAM91A1 | 0.751795 | 3 | 0 | 3 |
| UBE2S | FAM24B | 0.745396 | 3 | 0 | 3 |
| UBE2S | PPP1R14C | 0.743986 | 3 | 0 | 3 |
| UBE2S | POLR3A | 0.743114 | 4 | 0 | 4 |
| UBE2S | COLGALT1 | 0.739362 | 8 | 0 | 8 |
| UBE2S | PNPT1 | 0.73682 | 4 | 0 | 4 |
| UBE2S | LONP1 | 0.735778 | 9 | 0 | 8 |
| UBE2S | RNASEH2A | 0.734559 | 9 | 0 | 9 |
| UBE2S | SHISA2 | 0.728212 | 4 | 0 | 4 |
| UBE2S | CENPK | 0.726309 | 3 | 0 | 3 |
| UBE2S | C16orf95 | 0.725138 | 3 | 0 | 3 |
| UBE2S | CNOT3 | 0.721482 | 7 | 0 | 7 |
For details and further investigation, click here
