| Full name: kallikrein related peptidase 3 | Alias Symbol: PSA | ||
| Type: protein-coding gene | Cytoband: 19q13.33 | ||
| Entrez ID: 354 | HGNC ID: HGNC:6364 | Ensembl Gene: ENSG00000142515 | OMIM ID: 176820 |
| Drug and gene relationship at DGIdb | |||
KLK3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05200 | Pathways in cancer | |
| hsa05215 | Prostate cancer |
Expression of KLK3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KLK3 | 354 | 231629_x_at | 0.0409 | 0.8819 | |
| GSE20347 | KLK3 | 354 | 204583_x_at | -0.0845 | 0.3661 | |
| GSE23400 | KLK3 | 354 | 204583_x_at | -0.1945 | 0.0000 | |
| GSE26886 | KLK3 | 354 | 231629_x_at | -0.5779 | 0.0036 | |
| GSE29001 | KLK3 | 354 | 204583_x_at | -0.0976 | 0.4557 | |
| GSE38129 | KLK3 | 354 | 204583_x_at | -0.2119 | 0.0360 | |
| GSE45670 | KLK3 | 354 | 231629_x_at | 0.2982 | 0.0069 | |
| GSE53622 | KLK3 | 354 | 50345 | 0.8312 | 0.0000 | |
| GSE53624 | KLK3 | 354 | 50345 | 0.8075 | 0.0000 | |
| GSE63941 | KLK3 | 354 | 231629_x_at | 0.2521 | 0.1123 | |
| GSE77861 | KLK3 | 354 | 231629_x_at | -0.0793 | 0.3706 | |
| GSE97050 | KLK3 | 354 | A_33_P3215838 | -0.1701 | 0.3997 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by KLK3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KLK3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KLK3 | 354 | 3 | 4 | 23 | |
| GSE20123 | KLK3 | 354 | 3 | 3 | 24 | |
| GSE43470 | KLK3 | 354 | 4 | 11 | 28 | |
| GSE46452 | KLK3 | 354 | 45 | 1 | 13 | |
| GSE47630 | KLK3 | 354 | 9 | 6 | 25 | |
| GSE54993 | KLK3 | 354 | 17 | 4 | 49 | |
| GSE54994 | KLK3 | 354 | 4 | 14 | 35 | |
| GSE60625 | KLK3 | 354 | 9 | 0 | 2 | |
| GSE74703 | KLK3 | 354 | 4 | 7 | 25 | |
| GSE74704 | KLK3 | 354 | 3 | 1 | 16 | |
| TCGA | KLK3 | 354 | 14 | 19 | 63 |
Total number of gains: 115; Total number of losses: 70; Total Number of normals: 303.
Somatic mutations of KLK3:
Generating mutation plots.
Highly correlated genes for KLK3:
Showing top 20/883 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KLK3 | MS4A18 | 0.772296 | 3 | 0 | 3 |
| KLK3 | TMEM26 | 0.770621 | 3 | 0 | 3 |
| KLK3 | PHF7 | 0.764399 | 6 | 0 | 6 |
| KLK3 | MRGPRG | 0.747189 | 3 | 0 | 3 |
| KLK3 | OR7D4 | 0.747178 | 3 | 0 | 3 |
| KLK3 | RFX8 | 0.74317 | 3 | 0 | 3 |
| KLK3 | LYZL2 | 0.737744 | 3 | 0 | 3 |
| KLK3 | OR56A5 | 0.732586 | 3 | 0 | 3 |
| KLK3 | LCN8 | 0.731131 | 3 | 0 | 3 |
| KLK3 | LHB | 0.727981 | 3 | 0 | 3 |
| KLK3 | GPRIN1 | 0.725735 | 3 | 0 | 3 |
| KLK3 | OR2G2 | 0.721902 | 3 | 0 | 3 |
| KLK3 | NPM2 | 0.721107 | 4 | 0 | 4 |
| KLK3 | OR10W1 | 0.720755 | 3 | 0 | 3 |
| KLK3 | BLACE | 0.719739 | 3 | 0 | 3 |
| KLK3 | SULT1C3 | 0.717511 | 3 | 0 | 3 |
| KLK3 | ABCB9 | 0.716947 | 3 | 0 | 3 |
| KLK3 | FAM71F1 | 0.715957 | 3 | 0 | 3 |
| KLK3 | GPR32 | 0.715102 | 5 | 0 | 4 |
| KLK3 | PSMB11 | 0.714088 | 3 | 0 | 3 |
For details and further investigation, click here
