| Full name: apolipoprotein C3 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 11q23.3 | ||
| Entrez ID: 345 | HGNC ID: HGNC:610 | Ensembl Gene: ENSG00000110245 | OMIM ID: 107720 |
| Drug and gene relationship at DGIdb | |||
APOC3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa03320 | PPAR signaling pathway |
Expression of APOC3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | APOC3 | 345 | 205820_s_at | -0.2279 | 0.4586 | |
| GSE20347 | APOC3 | 345 | 205820_s_at | -0.1269 | 0.1057 | |
| GSE23400 | APOC3 | 345 | 205820_s_at | -0.0815 | 0.0015 | |
| GSE26886 | APOC3 | 345 | 231587_at | 0.0750 | 0.5850 | |
| GSE29001 | APOC3 | 345 | 205820_s_at | 0.0079 | 0.9527 | |
| GSE38129 | APOC3 | 345 | 205820_s_at | -0.1577 | 0.0268 | |
| GSE45670 | APOC3 | 345 | 231587_at | -0.0758 | 0.4540 | |
| GSE53622 | APOC3 | 345 | 79748 | 0.0483 | 0.5793 | |
| GSE53624 | APOC3 | 345 | 79748 | -0.0539 | 0.5898 | |
| GSE63941 | APOC3 | 345 | 205820_s_at | 0.5750 | 0.0017 | |
| GSE77861 | APOC3 | 345 | 205820_s_at | -0.0527 | 0.6486 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by APOC3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of APOC3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | APOC3 | 345 | 0 | 13 | 17 | |
| GSE20123 | APOC3 | 345 | 0 | 13 | 17 | |
| GSE43470 | APOC3 | 345 | 2 | 8 | 33 | |
| GSE46452 | APOC3 | 345 | 3 | 26 | 30 | |
| GSE47630 | APOC3 | 345 | 2 | 19 | 19 | |
| GSE54993 | APOC3 | 345 | 10 | 0 | 60 | |
| GSE54994 | APOC3 | 345 | 5 | 19 | 29 | |
| GSE60625 | APOC3 | 345 | 0 | 3 | 8 | |
| GSE74703 | APOC3 | 345 | 1 | 5 | 30 | |
| GSE74704 | APOC3 | 345 | 0 | 9 | 11 | |
| TCGA | APOC3 | 345 | 5 | 50 | 41 |
Total number of gains: 28; Total number of losses: 165; Total Number of normals: 295.
Somatic mutations of APOC3:
Generating mutation plots.
Highly correlated genes for APOC3:
Showing top 20/348 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| APOC3 | LINC00315 | 0.696582 | 4 | 0 | 3 |
| APOC3 | TMEM252 | 0.693904 | 3 | 0 | 3 |
| APOC3 | SLC25A48 | 0.68376 | 3 | 0 | 3 |
| APOC3 | PROCA1 | 0.67151 | 3 | 0 | 3 |
| APOC3 | TMEM105 | 0.652407 | 3 | 0 | 3 |
| APOC3 | LRRC43 | 0.650085 | 3 | 0 | 3 |
| APOC3 | LINC00917 | 0.64983 | 4 | 0 | 3 |
| APOC3 | SHISA7 | 0.643734 | 3 | 0 | 3 |
| APOC3 | TNNI3 | 0.63316 | 4 | 0 | 4 |
| APOC3 | ADARB2-AS1 | 0.631762 | 3 | 0 | 3 |
| APOC3 | SUN5 | 0.62611 | 3 | 0 | 3 |
| APOC3 | LINC00523 | 0.622712 | 5 | 0 | 4 |
| APOC3 | SERPIND1 | 0.620461 | 3 | 0 | 3 |
| APOC3 | CASC22 | 0.617746 | 3 | 0 | 3 |
| APOC3 | C16orf86 | 0.616879 | 4 | 0 | 4 |
| APOC3 | ANKRD33 | 0.616494 | 4 | 0 | 3 |
| APOC3 | PRR7-AS1 | 0.615501 | 3 | 0 | 3 |
| APOC3 | F2RL3 | 0.614962 | 4 | 0 | 4 |
| APOC3 | NKX6-3 | 0.613335 | 4 | 0 | 4 |
| APOC3 | DSC2 | 0.61307 | 3 | 0 | 3 |
For details and further investigation, click here
