| Full name: troponin I3, cardiac type | Alias Symbol: TNNC1|CMH7 | ||
| Type: protein-coding gene | Cytoband: 19q13.42 | ||
| Entrez ID: 7137 | HGNC ID: HGNC:11947 | Ensembl Gene: ENSG00000129991 | OMIM ID: 191044 |
| Drug and gene relationship at DGIdb | |||
TNNI3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04024 | cAMP signaling pathway | |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
Expression of TNNI3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TNNI3 | 7137 | 205742_at | -0.0605 | 0.8631 | |
| GSE20347 | TNNI3 | 7137 | 205742_at | 0.2130 | 0.2810 | |
| GSE23400 | TNNI3 | 7137 | 205742_at | -0.0478 | 0.1058 | |
| GSE26886 | TNNI3 | 7137 | 205742_at | 0.2404 | 0.1283 | |
| GSE29001 | TNNI3 | 7137 | 205742_at | 0.0160 | 0.9406 | |
| GSE38129 | TNNI3 | 7137 | 205742_at | 0.3888 | 0.0726 | |
| GSE45670 | TNNI3 | 7137 | 205742_at | 0.5492 | 0.1175 | |
| GSE63941 | TNNI3 | 7137 | 205742_at | 1.1101 | 0.0861 | |
| GSE77861 | TNNI3 | 7137 | 205742_at | -0.1508 | 0.3364 | |
| SRP159526 | TNNI3 | 7137 | RNAseq | 1.9847 | 0.0015 | |
| TCGA | TNNI3 | 7137 | RNAseq | 4.7847 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by TNNI3 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of TNNI3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TNNI3 | 7137 | 3 | 4 | 23 | |
| GSE20123 | TNNI3 | 7137 | 3 | 3 | 24 | |
| GSE43470 | TNNI3 | 7137 | 3 | 11 | 29 | |
| GSE46452 | TNNI3 | 7137 | 45 | 1 | 13 | |
| GSE47630 | TNNI3 | 7137 | 8 | 6 | 26 | |
| GSE54993 | TNNI3 | 7137 | 17 | 4 | 49 | |
| GSE54994 | TNNI3 | 7137 | 4 | 13 | 36 | |
| GSE60625 | TNNI3 | 7137 | 9 | 0 | 2 | |
| GSE74703 | TNNI3 | 7137 | 3 | 7 | 26 | |
| GSE74704 | TNNI3 | 7137 | 3 | 1 | 16 | |
| TCGA | TNNI3 | 7137 | 19 | 14 | 63 |
Total number of gains: 117; Total number of losses: 64; Total Number of normals: 307.
Somatic mutations of TNNI3:
Generating mutation plots.
Highly correlated genes for TNNI3:
Showing top 20/89 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TNNI3 | SLC6A19 | 0.701069 | 3 | 0 | 3 |
| TNNI3 | C1orf127 | 0.650292 | 3 | 0 | 3 |
| TNNI3 | DLX4 | 0.638721 | 3 | 0 | 3 |
| TNNI3 | APOC3 | 0.63316 | 4 | 0 | 4 |
| TNNI3 | TRABD2A | 0.631743 | 3 | 0 | 3 |
| TNNI3 | GPR182 | 0.629193 | 3 | 0 | 3 |
| TNNI3 | MCEMP1 | 0.627919 | 3 | 0 | 3 |
| TNNI3 | AMER3 | 0.621651 | 3 | 0 | 3 |
| TNNI3 | CELF5 | 0.618634 | 3 | 0 | 3 |
| TNNI3 | ODAM | 0.616594 | 3 | 0 | 3 |
| TNNI3 | OR3A1 | 0.613594 | 3 | 0 | 3 |
| TNNI3 | EMID1 | 0.612583 | 3 | 0 | 3 |
| TNNI3 | FGG | 0.611418 | 4 | 0 | 3 |
| TNNI3 | G6PC2 | 0.611267 | 3 | 0 | 3 |
| TNNI3 | NGFR | 0.609681 | 3 | 0 | 3 |
| TNNI3 | ZMYND10 | 0.609158 | 3 | 0 | 3 |
| TNNI3 | ZCCHC13 | 0.605969 | 3 | 0 | 3 |
| TNNI3 | CLDN9 | 0.60299 | 4 | 0 | 4 |
| TNNI3 | CHRNA4 | 0.594527 | 4 | 0 | 3 |
| TNNI3 | LINC00661 | 0.592798 | 3 | 0 | 3 |
For details and further investigation, click here
