| Full name: serpin family D member 1 | Alias Symbol: HC-II|HLS2|HC2|D22S673 | ||
| Type: protein-coding gene | Cytoband: 22q11.21 | ||
| Entrez ID: 3053 | HGNC ID: HGNC:4838 | Ensembl Gene: ENSG00000099937 | OMIM ID: 142360 |
| Drug and gene relationship at DGIdb | |||
SERPIND1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04610 | Complement and coagulation cascades |
Expression of SERPIND1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SERPIND1 | 3053 | 205576_at | -0.0928 | 0.7955 | |
| GSE20347 | SERPIND1 | 3053 | 205576_at | 0.0498 | 0.4728 | |
| GSE23400 | SERPIND1 | 3053 | 205576_at | -0.0981 | 0.0034 | |
| GSE26886 | SERPIND1 | 3053 | 205576_at | -0.1436 | 0.0952 | |
| GSE29001 | SERPIND1 | 3053 | 205576_at | -0.0310 | 0.8471 | |
| GSE38129 | SERPIND1 | 3053 | 205576_at | -0.0592 | 0.3518 | |
| GSE45670 | SERPIND1 | 3053 | 205576_at | 0.0013 | 0.9982 | |
| GSE53622 | SERPIND1 | 3053 | 4820 | -0.4486 | 0.0009 | |
| GSE53624 | SERPIND1 | 3053 | 4820 | -0.9121 | 0.0000 | |
| GSE63941 | SERPIND1 | 3053 | 205576_at | -0.1651 | 0.5941 | |
| GSE77861 | SERPIND1 | 3053 | 205576_at | -0.0136 | 0.8840 | |
| GSE97050 | SERPIND1 | 3053 | A_33_P3241511 | 0.0766 | 0.8689 | |
| SRP133303 | SERPIND1 | 3053 | RNAseq | -0.3050 | 0.1019 | |
| TCGA | SERPIND1 | 3053 | RNAseq | -2.1684 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by SERPIND1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SERPIND1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SERPIND1 | 3053 | 6 | 7 | 17 | |
| GSE20123 | SERPIND1 | 3053 | 6 | 7 | 17 | |
| GSE43470 | SERPIND1 | 3053 | 4 | 7 | 32 | |
| GSE46452 | SERPIND1 | 3053 | 33 | 1 | 25 | |
| GSE47630 | SERPIND1 | 3053 | 8 | 5 | 27 | |
| GSE54993 | SERPIND1 | 3053 | 3 | 6 | 61 | |
| GSE54994 | SERPIND1 | 3053 | 11 | 7 | 35 | |
| GSE60625 | SERPIND1 | 3053 | 5 | 0 | 6 | |
| GSE74703 | SERPIND1 | 3053 | 4 | 5 | 27 | |
| GSE74704 | SERPIND1 | 3053 | 3 | 4 | 13 | |
| TCGA | SERPIND1 | 3053 | 27 | 17 | 52 |
Total number of gains: 110; Total number of losses: 66; Total Number of normals: 312.
Somatic mutations of SERPIND1:
Generating mutation plots.
Highly correlated genes for SERPIND1:
Showing top 20/418 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SERPIND1 | KCNIP2 | 0.775074 | 3 | 0 | 3 |
| SERPIND1 | AGTR2 | 0.767526 | 3 | 0 | 3 |
| SERPIND1 | CALCB | 0.765605 | 3 | 0 | 3 |
| SERPIND1 | ILVBL | 0.721353 | 3 | 0 | 3 |
| SERPIND1 | CCIN | 0.720351 | 4 | 0 | 4 |
| SERPIND1 | C1orf68 | 0.716128 | 4 | 0 | 4 |
| SERPIND1 | KCNA10 | 0.713021 | 3 | 0 | 3 |
| SERPIND1 | ZNF286A | 0.710982 | 3 | 0 | 3 |
| SERPIND1 | SIT1 | 0.710864 | 3 | 0 | 3 |
| SERPIND1 | BTN1A1 | 0.701854 | 5 | 0 | 4 |
| SERPIND1 | PPP1R37 | 0.694456 | 4 | 0 | 4 |
| SERPIND1 | ESR2 | 0.694035 | 3 | 0 | 3 |
| SERPIND1 | CRX | 0.690056 | 3 | 0 | 3 |
| SERPIND1 | MAPK4 | 0.68831 | 3 | 0 | 3 |
| SERPIND1 | FAM76A | 0.685276 | 3 | 0 | 3 |
| SERPIND1 | PVR | 0.675964 | 3 | 0 | 3 |
| SERPIND1 | XYLB | 0.671844 | 3 | 0 | 3 |
| SERPIND1 | KCNC4 | 0.669515 | 5 | 0 | 4 |
| SERPIND1 | ENTPD2 | 0.66638 | 3 | 0 | 3 |
| SERPIND1 | RAB4B | 0.66424 | 3 | 0 | 3 |
For details and further investigation, click here
