| Full name: desmocollin 2 | Alias Symbol: CDHF2 | ||
| Type: protein-coding gene | Cytoband: 18q12.1 | ||
| Entrez ID: 1824 | HGNC ID: HGNC:3036 | Ensembl Gene: ENSG00000134755 | OMIM ID: 125645 |
| Drug and gene relationship at DGIdb | |||
Expression of DSC2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DSC2 | 1824 | 226817_at | -1.3772 | 0.2189 | |
| GSE20347 | DSC2 | 1824 | 204751_x_at | -1.9642 | 0.0000 | |
| GSE23400 | DSC2 | 1824 | 204751_x_at | -0.8646 | 0.0001 | |
| GSE26886 | DSC2 | 1824 | 226817_at | -2.2312 | 0.0000 | |
| GSE29001 | DSC2 | 1824 | 204750_s_at | -1.6314 | 0.0344 | |
| GSE38129 | DSC2 | 1824 | 204750_s_at | -0.8194 | 0.2096 | |
| GSE45670 | DSC2 | 1824 | 226817_at | -0.1948 | 0.3844 | |
| GSE53622 | DSC2 | 1824 | 37575 | -1.2853 | 0.0000 | |
| GSE53624 | DSC2 | 1824 | 37575 | -1.5663 | 0.0000 | |
| GSE63941 | DSC2 | 1824 | 226817_at | 4.9181 | 0.0005 | |
| GSE77861 | DSC2 | 1824 | 226817_at | -0.6149 | 0.3453 | |
| GSE97050 | DSC2 | 1824 | A_23_P4494 | 0.5201 | 0.7303 | |
| SRP007169 | DSC2 | 1824 | RNAseq | -1.1706 | 0.0695 | |
| SRP008496 | DSC2 | 1824 | RNAseq | -1.1528 | 0.0125 | |
| SRP064894 | DSC2 | 1824 | RNAseq | -1.4394 | 0.0024 | |
| SRP133303 | DSC2 | 1824 | RNAseq | -1.4335 | 0.0005 | |
| SRP159526 | DSC2 | 1824 | RNAseq | -2.5084 | 0.0000 | |
| SRP193095 | DSC2 | 1824 | RNAseq | -1.6056 | 0.0000 | |
| SRP219564 | DSC2 | 1824 | RNAseq | -2.5412 | 0.0149 | |
| TCGA | DSC2 | 1824 | RNAseq | 0.3696 | 0.0040 |
Upregulated datasets: 1; Downregulated datasets: 11.
Survival by DSC2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DSC2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DSC2 | 1824 | 3 | 6 | 21 | |
| GSE20123 | DSC2 | 1824 | 3 | 6 | 21 | |
| GSE43470 | DSC2 | 1824 | 0 | 2 | 41 | |
| GSE46452 | DSC2 | 1824 | 1 | 25 | 33 | |
| GSE47630 | DSC2 | 1824 | 5 | 20 | 15 | |
| GSE54993 | DSC2 | 1824 | 7 | 1 | 62 | |
| GSE54994 | DSC2 | 1824 | 3 | 15 | 35 | |
| GSE60625 | DSC2 | 1824 | 0 | 4 | 7 | |
| GSE74703 | DSC2 | 1824 | 0 | 2 | 34 | |
| GSE74704 | DSC2 | 1824 | 1 | 5 | 14 | |
| TCGA | DSC2 | 1824 | 14 | 36 | 46 |
Total number of gains: 37; Total number of losses: 122; Total Number of normals: 329.
Somatic mutations of DSC2:
Generating mutation plots.
Highly correlated genes for DSC2:
Showing top 20/995 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DSC2 | DSG3 | 0.836884 | 13 | 0 | 13 |
| DSC2 | KRT6C | 0.801364 | 4 | 0 | 4 |
| DSC2 | RHBDL2 | 0.776587 | 6 | 0 | 6 |
| DSC2 | CYSRT1 | 0.77611 | 6 | 0 | 6 |
| DSC2 | SH3PXD2A-AS1 | 0.773686 | 3 | 0 | 3 |
| DSC2 | GJB2 | 0.770243 | 7 | 0 | 7 |
| DSC2 | ANXA1 | 0.76758 | 12 | 0 | 12 |
| DSC2 | TMEM154 | 0.765865 | 8 | 0 | 7 |
| DSC2 | MPZL3 | 0.762188 | 7 | 0 | 7 |
| DSC2 | EVPL | 0.761677 | 12 | 0 | 12 |
| DSC2 | BTBD11 | 0.755398 | 8 | 0 | 7 |
| DSC2 | DMKN | 0.755057 | 8 | 0 | 7 |
| DSC2 | TGM1 | 0.753891 | 12 | 0 | 12 |
| DSC2 | CSTB | 0.753546 | 12 | 0 | 12 |
| DSC2 | MALL | 0.753408 | 13 | 0 | 12 |
| DSC2 | KRT83 | 0.752343 | 4 | 0 | 3 |
| DSC2 | LYPD3 | 0.750482 | 13 | 0 | 12 |
| DSC2 | GRHL3 | 0.747483 | 9 | 0 | 9 |
| DSC2 | ZNF185 | 0.747158 | 13 | 0 | 12 |
| DSC2 | S100A14 | 0.745429 | 13 | 0 | 12 |
For details and further investigation, click here
