| Full name: INSC spindle orientation adaptor protein | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 11p15.2 | ||
| Entrez ID: 387755 | HGNC ID: HGNC:33116 | Ensembl Gene: ENSG00000188487 | OMIM ID: 610668 |
| Drug and gene relationship at DGIdb | |||
Expression of INSC:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | INSC | 387755 | 237056_at | -0.3161 | 0.3789 | |
| GSE26886 | INSC | 387755 | 237056_at | 0.0276 | 0.8312 | |
| GSE45670 | INSC | 387755 | 237056_at | -0.2886 | 0.0436 | |
| GSE53622 | INSC | 387755 | 9026 | -0.0031 | 0.9751 | |
| GSE53624 | INSC | 387755 | 9026 | 0.0724 | 0.4650 | |
| GSE63941 | INSC | 387755 | 237056_at | -0.0416 | 0.8805 | |
| GSE77861 | INSC | 387755 | 237056_at | -0.0532 | 0.4478 | |
| GSE97050 | INSC | 387755 | A_33_P3814721 | -0.1494 | 0.5742 | |
| SRP133303 | INSC | 387755 | RNAseq | 0.1736 | 0.5721 | |
| TCGA | INSC | 387755 | RNAseq | -2.9011 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by INSC expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of INSC:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | INSC | 387755 | 1 | 10 | 19 | |
| GSE20123 | INSC | 387755 | 1 | 10 | 19 | |
| GSE43470 | INSC | 387755 | 1 | 5 | 37 | |
| GSE46452 | INSC | 387755 | 7 | 5 | 47 | |
| GSE47630 | INSC | 387755 | 3 | 11 | 26 | |
| GSE54993 | INSC | 387755 | 3 | 0 | 67 | |
| GSE54994 | INSC | 387755 | 4 | 12 | 37 | |
| GSE60625 | INSC | 387755 | 0 | 0 | 11 | |
| GSE74703 | INSC | 387755 | 1 | 3 | 32 | |
| GSE74704 | INSC | 387755 | 0 | 9 | 11 | |
| TCGA | INSC | 387755 | 11 | 31 | 54 |
Total number of gains: 32; Total number of losses: 96; Total Number of normals: 360.
Somatic mutations of INSC:
Generating mutation plots.
Highly correlated genes for INSC:
Showing top 20/350 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| INSC | PNMA3 | 0.878587 | 3 | 0 | 3 |
| INSC | OR2T1 | 0.862612 | 3 | 0 | 3 |
| INSC | OR2T27 | 0.859347 | 3 | 0 | 3 |
| INSC | YY2 | 0.852442 | 3 | 0 | 3 |
| INSC | PRSS38 | 0.848624 | 3 | 0 | 3 |
| INSC | TSSK3 | 0.846749 | 3 | 0 | 3 |
| INSC | ABTB1 | 0.845092 | 3 | 0 | 3 |
| INSC | OTOG | 0.83964 | 3 | 0 | 3 |
| INSC | THRA | 0.834438 | 3 | 0 | 3 |
| INSC | TTC21A | 0.834354 | 3 | 0 | 3 |
| INSC | DCDC1 | 0.832081 | 3 | 0 | 3 |
| INSC | LRIT1 | 0.830703 | 3 | 0 | 3 |
| INSC | CLDN9 | 0.829217 | 3 | 0 | 3 |
| INSC | ZNF236 | 0.826109 | 3 | 0 | 3 |
| INSC | USP51 | 0.825829 | 3 | 0 | 3 |
| INSC | AANAT | 0.825455 | 3 | 0 | 3 |
| INSC | TTLL9 | 0.822191 | 3 | 0 | 3 |
| INSC | GYPE | 0.817669 | 3 | 0 | 3 |
| INSC | SLC26A1 | 0.817437 | 3 | 0 | 3 |
| INSC | BBC3 | 0.81371 | 3 | 0 | 3 |
For details and further investigation, click here
