| Full name: potassium voltage-gated channel subfamily H member 3 | Alias Symbol: Kv12.2|BEC1|elk2 | ||
| Type: protein-coding gene | Cytoband: 12q13.12 | ||
| Entrez ID: 23416 | HGNC ID: HGNC:6252 | Ensembl Gene: ENSG00000135519 | OMIM ID: 604527 |
| Drug and gene relationship at DGIdb | |||
Expression of KCNH3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KCNH3 | 23416 | 223726_at | -0.0332 | 0.9181 | |
| GSE26886 | KCNH3 | 23416 | 223726_at | -0.0779 | 0.5881 | |
| GSE45670 | KCNH3 | 23416 | 223726_at | 0.0704 | 0.4908 | |
| GSE53622 | KCNH3 | 23416 | 83894 | 0.3139 | 0.0003 | |
| GSE53624 | KCNH3 | 23416 | 83894 | 0.2460 | 0.0135 | |
| GSE63941 | KCNH3 | 23416 | 223726_at | 0.4728 | 0.0082 | |
| GSE77861 | KCNH3 | 23416 | 223726_at | -0.0011 | 0.9947 | |
| GSE97050 | KCNH3 | 23416 | A_33_P3253672 | 0.1242 | 0.5122 | |
| SRP133303 | KCNH3 | 23416 | RNAseq | 0.6536 | 0.1611 | |
| SRP159526 | KCNH3 | 23416 | RNAseq | 2.4004 | 0.0235 | |
| SRP219564 | KCNH3 | 23416 | RNAseq | 0.4965 | 0.3863 | |
| TCGA | KCNH3 | 23416 | RNAseq | 0.8622 | 0.0222 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by KCNH3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KCNH3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KCNH3 | 23416 | 6 | 1 | 23 | |
| GSE20123 | KCNH3 | 23416 | 7 | 1 | 22 | |
| GSE43470 | KCNH3 | 23416 | 3 | 1 | 39 | |
| GSE46452 | KCNH3 | 23416 | 8 | 1 | 50 | |
| GSE47630 | KCNH3 | 23416 | 11 | 2 | 27 | |
| GSE54993 | KCNH3 | 23416 | 0 | 5 | 65 | |
| GSE54994 | KCNH3 | 23416 | 4 | 1 | 48 | |
| GSE60625 | KCNH3 | 23416 | 0 | 0 | 11 | |
| GSE74703 | KCNH3 | 23416 | 3 | 1 | 32 | |
| GSE74704 | KCNH3 | 23416 | 5 | 1 | 14 | |
| TCGA | KCNH3 | 23416 | 16 | 11 | 69 |
Total number of gains: 63; Total number of losses: 25; Total Number of normals: 400.
Somatic mutations of KCNH3:
Generating mutation plots.
Highly correlated genes for KCNH3:
Showing top 20/623 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KCNH3 | STRC | 0.907377 | 3 | 0 | 3 |
| KCNH3 | DCDC1 | 0.897633 | 3 | 0 | 3 |
| KCNH3 | YY2 | 0.864419 | 3 | 0 | 3 |
| KCNH3 | PLA2G2C | 0.85293 | 3 | 0 | 3 |
| KCNH3 | PGP | 0.847532 | 3 | 0 | 3 |
| KCNH3 | C9orf153 | 0.842657 | 3 | 0 | 3 |
| KCNH3 | C1QL2 | 0.835558 | 3 | 0 | 3 |
| KCNH3 | DEFB121 | 0.83208 | 4 | 0 | 4 |
| KCNH3 | OR2T27 | 0.829715 | 3 | 0 | 3 |
| KCNH3 | KRTAP10-12 | 0.828694 | 3 | 0 | 3 |
| KCNH3 | MRGPRG | 0.825768 | 3 | 0 | 3 |
| KCNH3 | DEFB128 | 0.824405 | 3 | 0 | 3 |
| KCNH3 | BBC3 | 0.822659 | 3 | 0 | 3 |
| KCNH3 | OR2A5 | 0.816091 | 3 | 0 | 3 |
| KCNH3 | FAM131A | 0.811426 | 3 | 0 | 3 |
| KCNH3 | TMEM235 | 0.811264 | 4 | 0 | 4 |
| KCNH3 | RNF180 | 0.809368 | 3 | 0 | 3 |
| KCNH3 | LBX2 | 0.808163 | 3 | 0 | 3 |
| KCNH3 | C19orf71 | 0.803663 | 3 | 0 | 3 |
| KCNH3 | PRSS38 | 0.802966 | 3 | 0 | 3 |
For details and further investigation, click here
