| Full name: bromodomain containing 1 | Alias Symbol: BRL|BRPF2 | ||
| Type: protein-coding gene | Cytoband: 22q13.33 | ||
| Entrez ID: 23774 | HGNC ID: HGNC:1102 | Ensembl Gene: ENSG00000100425 | OMIM ID: 604589 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of BRD1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | BRD1 | 23774 | 204520_x_at | 0.0694 | 0.8823 | |
| GSE20347 | BRD1 | 23774 | 204520_x_at | -0.3612 | 0.0067 | |
| GSE23400 | BRD1 | 23774 | 204520_x_at | -0.0025 | 0.9767 | |
| GSE26886 | BRD1 | 23774 | 204520_x_at | 0.2591 | 0.1327 | |
| GSE29001 | BRD1 | 23774 | 204520_x_at | 0.0756 | 0.7524 | |
| GSE38129 | BRD1 | 23774 | 204520_x_at | -0.0862 | 0.5480 | |
| GSE45670 | BRD1 | 23774 | 204520_x_at | 0.0160 | 0.9289 | |
| GSE53622 | BRD1 | 23774 | 13576 | -0.2777 | 0.0000 | |
| GSE53624 | BRD1 | 23774 | 13576 | -0.2317 | 0.0000 | |
| GSE63941 | BRD1 | 23774 | 204520_x_at | 0.1494 | 0.8298 | |
| GSE77861 | BRD1 | 23774 | 215460_x_at | 0.5045 | 0.0126 | |
| GSE97050 | BRD1 | 23774 | A_23_P166536 | -0.2936 | 0.2540 | |
| SRP007169 | BRD1 | 23774 | RNAseq | 0.2467 | 0.5519 | |
| SRP008496 | BRD1 | 23774 | RNAseq | 0.2597 | 0.3819 | |
| SRP064894 | BRD1 | 23774 | RNAseq | -0.1424 | 0.5709 | |
| SRP133303 | BRD1 | 23774 | RNAseq | -0.2031 | 0.2456 | |
| SRP159526 | BRD1 | 23774 | RNAseq | 0.0662 | 0.7306 | |
| SRP193095 | BRD1 | 23774 | RNAseq | -0.1009 | 0.3601 | |
| SRP219564 | BRD1 | 23774 | RNAseq | -0.1203 | 0.6834 | |
| TCGA | BRD1 | 23774 | RNAseq | -0.0408 | 0.3795 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by BRD1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of BRD1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | BRD1 | 23774 | 3 | 8 | 19 | |
| GSE20123 | BRD1 | 23774 | 3 | 8 | 19 | |
| GSE43470 | BRD1 | 23774 | 2 | 8 | 33 | |
| GSE46452 | BRD1 | 23774 | 31 | 2 | 26 | |
| GSE47630 | BRD1 | 23774 | 9 | 4 | 27 | |
| GSE54993 | BRD1 | 23774 | 4 | 6 | 60 | |
| GSE54994 | BRD1 | 23774 | 11 | 8 | 34 | |
| GSE60625 | BRD1 | 23774 | 5 | 0 | 6 | |
| GSE74703 | BRD1 | 23774 | 2 | 6 | 28 | |
| GSE74704 | BRD1 | 23774 | 1 | 4 | 15 | |
| TCGA | BRD1 | 23774 | 26 | 16 | 54 |
Total number of gains: 97; Total number of losses: 70; Total Number of normals: 321.
Somatic mutations of BRD1:
Generating mutation plots.
Highly correlated genes for BRD1:
Showing top 20/66 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BRD1 | ZNF30 | 0.736669 | 3 | 0 | 3 |
| BRD1 | ING5 | 0.734643 | 3 | 0 | 3 |
| BRD1 | ABHD11 | 0.733037 | 3 | 0 | 3 |
| BRD1 | C19orf25 | 0.724274 | 3 | 0 | 3 |
| BRD1 | UBL4A | 0.709707 | 3 | 0 | 3 |
| BRD1 | RAB40B | 0.707242 | 4 | 0 | 3 |
| BRD1 | VAMP4 | 0.696416 | 3 | 0 | 3 |
| BRD1 | RANBP3 | 0.660257 | 4 | 0 | 3 |
| BRD1 | RWDD3 | 0.651102 | 3 | 0 | 3 |
| BRD1 | CHP2 | 0.649811 | 4 | 0 | 3 |
| BRD1 | STK11 | 0.649273 | 4 | 0 | 3 |
| BRD1 | ZNF235 | 0.649139 | 3 | 0 | 3 |
| BRD1 | GOLGA2 | 0.63248 | 4 | 0 | 3 |
| BRD1 | UBTF | 0.625779 | 4 | 0 | 4 |
| BRD1 | TSSC4 | 0.625114 | 3 | 0 | 3 |
| BRD1 | ARFGEF1 | 0.625086 | 3 | 0 | 3 |
| BRD1 | USP27X | 0.615992 | 4 | 0 | 3 |
| BRD1 | ANKRD52 | 0.613975 | 3 | 0 | 3 |
| BRD1 | NRF1 | 0.613952 | 4 | 0 | 3 |
| BRD1 | TMUB1 | 0.610046 | 4 | 0 | 3 |
For details and further investigation, click here
