| Full name: serine/threonine kinase 11 | Alias Symbol: PJS|LKB1 | ||
| Type: protein-coding gene | Cytoband: 19p13.3 | ||
| Entrez ID: 6794 | HGNC ID: HGNC:11389 | Ensembl Gene: ENSG00000118046 | OMIM ID: 602216 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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STK11 involved pathways:
Expression of STK11:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | STK11 | 6794 | 41657_at | 0.5411 | 0.1628 | |
| GSE20347 | STK11 | 6794 | 41657_at | -0.0379 | 0.6742 | |
| GSE23400 | STK11 | 6794 | 41657_at | 0.0497 | 0.1626 | |
| GSE26886 | STK11 | 6794 | 231017_at | 0.4751 | 0.0899 | |
| GSE29001 | STK11 | 6794 | 41657_at | -0.3265 | 0.0360 | |
| GSE38129 | STK11 | 6794 | 41657_at | -0.0514 | 0.5305 | |
| GSE45670 | STK11 | 6794 | 231017_at | 0.1338 | 0.4728 | |
| GSE63941 | STK11 | 6794 | 231017_at | -0.3528 | 0.6255 | |
| GSE77861 | STK11 | 6794 | 41657_at | 0.1592 | 0.3524 | |
| GSE97050 | STK11 | 6794 | A_33_P3389148 | 0.0878 | 0.7209 | |
| SRP007169 | STK11 | 6794 | RNAseq | -0.7088 | 0.0364 | |
| SRP008496 | STK11 | 6794 | RNAseq | -0.4574 | 0.0218 | |
| SRP064894 | STK11 | 6794 | RNAseq | 0.3870 | 0.0808 | |
| SRP133303 | STK11 | 6794 | RNAseq | 0.0112 | 0.9512 | |
| SRP159526 | STK11 | 6794 | RNAseq | 0.2057 | 0.3081 | |
| SRP193095 | STK11 | 6794 | RNAseq | 0.1079 | 0.3186 | |
| SRP219564 | STK11 | 6794 | RNAseq | -0.3291 | 0.5213 | |
| TCGA | STK11 | 6794 | RNAseq | -0.0507 | 0.3888 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by STK11 expression:
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| TCGA |
Note: Click image to view full size file.
Copy number change of STK11:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | STK11 | 6794 | 4 | 6 | 20 | |
| GSE20123 | STK11 | 6794 | 4 | 5 | 21 | |
| GSE43470 | STK11 | 6794 | 1 | 11 | 31 | |
| GSE46452 | STK11 | 6794 | 47 | 1 | 11 | |
| GSE47630 | STK11 | 6794 | 5 | 7 | 28 | |
| GSE54993 | STK11 | 6794 | 13 | 4 | 53 | |
| GSE54994 | STK11 | 6794 | 8 | 15 | 30 | |
| GSE60625 | STK11 | 6794 | 9 | 0 | 2 | |
| GSE74703 | STK11 | 6794 | 1 | 8 | 27 | |
| GSE74704 | STK11 | 6794 | 3 | 3 | 14 | |
| TCGA | STK11 | 6794 | 7 | 25 | 64 |
Total number of gains: 102; Total number of losses: 85; Total Number of normals: 301.
Somatic mutations of STK11:
Generating mutation plots.
Highly correlated genes for STK11:
Showing top 20/225 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| STK11 | CNOT3 | 0.84857 | 3 | 0 | 3 |
| STK11 | RUNDC3A | 0.802979 | 3 | 0 | 3 |
| STK11 | CDK16 | 0.800728 | 3 | 0 | 3 |
| STK11 | ZNF687 | 0.794641 | 3 | 0 | 3 |
| STK11 | CYP11B1 | 0.784708 | 3 | 0 | 3 |
| STK11 | TMEM102 | 0.780417 | 3 | 0 | 3 |
| STK11 | HRK | 0.776414 | 3 | 0 | 3 |
| STK11 | PPP1R13B | 0.769423 | 3 | 0 | 3 |
| STK11 | C19orf53 | 0.758399 | 3 | 0 | 3 |
| STK11 | MBD6 | 0.756313 | 3 | 0 | 3 |
| STK11 | TMUB1 | 0.755266 | 4 | 0 | 3 |
| STK11 | PYGO2 | 0.752099 | 3 | 0 | 3 |
| STK11 | SMG5 | 0.746246 | 3 | 0 | 3 |
| STK11 | ADAM21 | 0.7449 | 3 | 0 | 3 |
| STK11 | LIM2 | 0.744897 | 3 | 0 | 3 |
| STK11 | ZNF500 | 0.729898 | 3 | 0 | 3 |
| STK11 | GTF2IRD2 | 0.729546 | 4 | 0 | 4 |
| STK11 | DUSP9 | 0.725906 | 3 | 0 | 3 |
| STK11 | SCLY | 0.724927 | 3 | 0 | 3 |
| STK11 | FMNL1 | 0.724709 | 3 | 0 | 3 |
For details and further investigation, click here
