| Full name: ADP ribosylation factor guanine nucleotide exchange factor 1 | Alias Symbol: DKFZP434L057|BIG1|ARFGEP1|p200 | ||
| Type: protein-coding gene | Cytoband: 8q13.2 | ||
| Entrez ID: 10565 | HGNC ID: HGNC:15772 | Ensembl Gene: ENSG00000066777 | OMIM ID: 604141 |
| Drug and gene relationship at DGIdb | |||
Expression of ARFGEF1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ARFGEF1 | 10565 | 202956_at | 0.4525 | 0.3860 | |
| GSE20347 | ARFGEF1 | 10565 | 202956_at | 0.1271 | 0.5546 | |
| GSE23400 | ARFGEF1 | 10565 | 216266_s_at | 0.1570 | 0.0586 | |
| GSE26886 | ARFGEF1 | 10565 | 202956_at | -0.2687 | 0.2933 | |
| GSE29001 | ARFGEF1 | 10565 | 202956_at | 0.2821 | 0.0645 | |
| GSE38129 | ARFGEF1 | 10565 | 202956_at | 0.2931 | 0.0650 | |
| GSE45670 | ARFGEF1 | 10565 | 202956_at | 0.1539 | 0.2194 | |
| GSE53622 | ARFGEF1 | 10565 | 61701 | -0.0689 | 0.2556 | |
| GSE53624 | ARFGEF1 | 10565 | 61701 | -0.1974 | 0.0001 | |
| GSE63941 | ARFGEF1 | 10565 | 202956_at | -0.4886 | 0.2429 | |
| GSE77861 | ARFGEF1 | 10565 | 202956_at | -0.0732 | 0.7303 | |
| GSE97050 | ARFGEF1 | 10565 | A_23_P82941 | 0.1270 | 0.5492 | |
| SRP007169 | ARFGEF1 | 10565 | RNAseq | 0.2050 | 0.4889 | |
| SRP008496 | ARFGEF1 | 10565 | RNAseq | 0.3000 | 0.1810 | |
| SRP064894 | ARFGEF1 | 10565 | RNAseq | 0.0113 | 0.9606 | |
| SRP133303 | ARFGEF1 | 10565 | RNAseq | 0.2541 | 0.0893 | |
| SRP159526 | ARFGEF1 | 10565 | RNAseq | -0.1466 | 0.5613 | |
| SRP193095 | ARFGEF1 | 10565 | RNAseq | -0.0891 | 0.2840 | |
| SRP219564 | ARFGEF1 | 10565 | RNAseq | -0.2337 | 0.3651 | |
| TCGA | ARFGEF1 | 10565 | RNAseq | -0.0497 | 0.3399 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ARFGEF1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ARFGEF1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ARFGEF1 | 10565 | 15 | 1 | 14 | |
| GSE20123 | ARFGEF1 | 10565 | 16 | 1 | 13 | |
| GSE43470 | ARFGEF1 | 10565 | 15 | 3 | 25 | |
| GSE46452 | ARFGEF1 | 10565 | 20 | 2 | 37 | |
| GSE47630 | ARFGEF1 | 10565 | 23 | 1 | 16 | |
| GSE54993 | ARFGEF1 | 10565 | 1 | 18 | 51 | |
| GSE54994 | ARFGEF1 | 10565 | 30 | 0 | 23 | |
| GSE60625 | ARFGEF1 | 10565 | 0 | 4 | 7 | |
| GSE74703 | ARFGEF1 | 10565 | 13 | 2 | 21 | |
| GSE74704 | ARFGEF1 | 10565 | 11 | 0 | 9 | |
| TCGA | ARFGEF1 | 10565 | 49 | 4 | 43 |
Total number of gains: 193; Total number of losses: 36; Total Number of normals: 259.
Somatic mutations of ARFGEF1:
Generating mutation plots.
Highly correlated genes for ARFGEF1:
Showing top 20/59 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ARFGEF1 | ZNF30 | 0.765778 | 3 | 0 | 3 |
| ARFGEF1 | IL22RA2 | 0.731272 | 3 | 0 | 3 |
| ARFGEF1 | CXorf38 | 0.710404 | 3 | 0 | 3 |
| ARFGEF1 | METTL18 | 0.702767 | 3 | 0 | 3 |
| ARFGEF1 | TFAP2C | 0.695807 | 4 | 0 | 3 |
| ARFGEF1 | D2HGDH | 0.685709 | 3 | 0 | 3 |
| ARFGEF1 | AACS | 0.680225 | 3 | 0 | 3 |
| ARFGEF1 | CDK12 | 0.672237 | 3 | 0 | 3 |
| ARFGEF1 | SLC27A5 | 0.669484 | 3 | 0 | 3 |
| ARFGEF1 | LCORL | 0.663058 | 3 | 0 | 3 |
| ARFGEF1 | GALK2 | 0.655761 | 3 | 0 | 3 |
| ARFGEF1 | EXO5 | 0.651009 | 3 | 0 | 3 |
| ARFGEF1 | SH2D1B | 0.650382 | 3 | 0 | 3 |
| ARFGEF1 | ZNF283 | 0.648875 | 4 | 0 | 3 |
| ARFGEF1 | RWDD3 | 0.638708 | 4 | 0 | 3 |
| ARFGEF1 | PHF10 | 0.631472 | 4 | 0 | 3 |
| ARFGEF1 | RAB40B | 0.631022 | 4 | 0 | 3 |
| ARFGEF1 | HS6ST2 | 0.629023 | 3 | 0 | 3 |
| ARFGEF1 | BRD1 | 0.625086 | 3 | 0 | 3 |
| ARFGEF1 | SLC39A11 | 0.622308 | 4 | 0 | 3 |
For details and further investigation, click here
