| Full name: nuclear respiratory factor 1 | Alias Symbol: EWG|ALPHA-PAL | ||
| Type: protein-coding gene | Cytoband: 7q32.2 | ||
| Entrez ID: 4899 | HGNC ID: HGNC:7996 | Ensembl Gene: ENSG00000106459 | OMIM ID: 600879 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of NRF1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NRF1 | 4899 | 204651_at | 0.3572 | 0.3373 | |
| GSE20347 | NRF1 | 4899 | 204651_at | 0.4552 | 0.0007 | |
| GSE23400 | NRF1 | 4899 | 204651_at | 0.1389 | 0.0016 | |
| GSE26886 | NRF1 | 4899 | 204651_at | 0.6703 | 0.0057 | |
| GSE29001 | NRF1 | 4899 | 204651_at | 0.5085 | 0.0465 | |
| GSE38129 | NRF1 | 4899 | 204651_at | 0.3395 | 0.0102 | |
| GSE45670 | NRF1 | 4899 | 204651_at | 0.0821 | 0.5033 | |
| GSE53622 | NRF1 | 4899 | 94727 | 0.1875 | 0.0095 | |
| GSE53624 | NRF1 | 4899 | 94727 | 0.3762 | 0.0000 | |
| GSE63941 | NRF1 | 4899 | 204651_at | -0.2008 | 0.5074 | |
| GSE77861 | NRF1 | 4899 | 211279_at | 0.0815 | 0.6001 | |
| GSE97050 | NRF1 | 4899 | A_23_P59418 | 0.1323 | 0.4776 | |
| SRP007169 | NRF1 | 4899 | RNAseq | 0.7457 | 0.1136 | |
| SRP008496 | NRF1 | 4899 | RNAseq | 1.6020 | 0.0001 | |
| SRP064894 | NRF1 | 4899 | RNAseq | 0.1945 | 0.0910 | |
| SRP133303 | NRF1 | 4899 | RNAseq | 0.2141 | 0.0838 | |
| SRP159526 | NRF1 | 4899 | RNAseq | 0.1753 | 0.2692 | |
| SRP193095 | NRF1 | 4899 | RNAseq | 0.1257 | 0.0356 | |
| SRP219564 | NRF1 | 4899 | RNAseq | 0.2733 | 0.2974 | |
| TCGA | NRF1 | 4899 | RNAseq | 0.0559 | 0.3428 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by NRF1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NRF1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NRF1 | 4899 | 8 | 1 | 21 | |
| GSE20123 | NRF1 | 4899 | 8 | 1 | 21 | |
| GSE43470 | NRF1 | 4899 | 2 | 3 | 38 | |
| GSE46452 | NRF1 | 4899 | 7 | 2 | 50 | |
| GSE47630 | NRF1 | 4899 | 7 | 4 | 29 | |
| GSE54993 | NRF1 | 4899 | 3 | 5 | 62 | |
| GSE54994 | NRF1 | 4899 | 8 | 8 | 37 | |
| GSE60625 | NRF1 | 4899 | 0 | 0 | 11 | |
| GSE74703 | NRF1 | 4899 | 2 | 3 | 31 | |
| GSE74704 | NRF1 | 4899 | 4 | 1 | 15 | |
| TCGA | NRF1 | 4899 | 29 | 21 | 46 |
Total number of gains: 78; Total number of losses: 49; Total Number of normals: 361.
Somatic mutations of NRF1:
Generating mutation plots.
Highly correlated genes for NRF1:
Showing top 20/237 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NRF1 | SOX30 | 0.779066 | 3 | 0 | 3 |
| NRF1 | WDR60 | 0.753969 | 3 | 0 | 3 |
| NRF1 | MIIP | 0.742653 | 4 | 0 | 3 |
| NRF1 | ATG4D | 0.712916 | 4 | 0 | 4 |
| NRF1 | ZNF230 | 0.7088 | 3 | 0 | 3 |
| NRF1 | HOXA11 | 0.698332 | 3 | 0 | 3 |
| NRF1 | C19orf53 | 0.689528 | 3 | 0 | 3 |
| NRF1 | ALDH16A1 | 0.686314 | 4 | 0 | 3 |
| NRF1 | BEND3 | 0.679958 | 5 | 0 | 4 |
| NRF1 | STK11 | 0.676131 | 4 | 0 | 3 |
| NRF1 | ZNF687 | 0.670762 | 4 | 0 | 4 |
| NRF1 | IFT122 | 0.6617 | 5 | 0 | 4 |
| NRF1 | NOC4L | 0.656161 | 4 | 0 | 4 |
| NRF1 | MIB2 | 0.650491 | 3 | 0 | 3 |
| NRF1 | GTF2IRD2 | 0.649059 | 5 | 0 | 4 |
| NRF1 | WDR83 | 0.648789 | 5 | 0 | 3 |
| NRF1 | UNC93B1 | 0.636127 | 3 | 0 | 3 |
| NRF1 | HOXB6 | 0.629267 | 3 | 0 | 3 |
| NRF1 | ALKBH2 | 0.628535 | 4 | 0 | 3 |
| NRF1 | DDX49 | 0.626349 | 4 | 0 | 3 |
For details and further investigation, click here
